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F Tezuka

Publications and source records attributed to F Tezuka.

88 records · Page 5Linked to original sources
PubMed1982

Morphometric analysis of cardiac hypertrophy: left ventricular shape and number of muscle-fiber layers across left ventricular wall.

Left ventricular hypertrophy was quantitatively analysed in reference to the relation of ventricular shape and intramyocardial muscle-fiber arrangement. The shape of the ventricle was defined by VL/WL, left ventricular capacity ratio. The ratio was depressed in concentric hypertrophy due to pressure overload and elevated in eccentric hypertrophy due to volume overload. Moreover, VL/WL was reversely correlated with Nf, number of muscle-fiber layers across the left ventricular wall. The results supported the following view on the morphogenesis of left ventricular hypertrophy: The muscle fibers show the strained piling vertically across the ventricular wall to cause wall thickening and cavity narrowing in concentric hypertrophy. On the other hand, the muscle fibers are piled strongly in parallel to the ventricular surface in eccentric hypertrophy to result in attenuation of the wall thickness and dilatation of the ventricular cavity.

Adult↗
PubMed1980

Quantitative analysis of the thickness of arterial walls in complete transposition of the great arteries.

Histometrical analyses were performed to estimate the medial thickness of the pulmonary and renal arteries in 35 autopsy cases of complete transposition of the great arteries (TGA). Twenty-one autopsy cases of ventricular septal defect (VSD) and 33 autopsy cases of normal cardiovascular systems were also examined for comparative analysis. The medial thickness of renal arteries was not influenced by age and remained unchanged throughout life. However, there were significant differences in medial thickness among TGA, VSD and normal cases. Normal and VSD cases showed higher value of medial thickness than TGA cases. The results suggest retarded development of the arterial walls in TGA. A positive correlation was observed between medial thickness and blood pressure in both the pulmonary and renal arterial systems in TGA and VSD. One of the most important findings in the comparative analysis of TGA and VSD was that the media of TGA was more remarkably attenuated than that of VSD at the same blood pressure level in both the pulmonary and renal arterial systems. The results suggest an underdevelopment of arterial media in pulmonary and systemic circulation in TGA and a possible supression of medial hypertrophy in TGA by some unknown factors.

Adolescent↗
PubMed1980

Indication for total correction of complete transposition of the great arteries with pulmonary hypertension.

Pulmonary vascular disease (PVD) was histologically evaluated and its severity was expressed as an index of PVD in 14 autopsied and eight biopsied cases of complete transposition of the great arteries (TGA) in patients more than 6 months of age. The index varied from 1.0 to 2.3 in six patients who had survived complete surgical repair and ranged from 2.3 to 3.3 in five patients who had died of PVD postoperatively. Consequently, an index of 2.2 could be regarded as an upper limit of PVD for complete surgical repair. The index was significantly correlated to some hemodynamic factors. From the regression equation, the value 2.2 of histologic index could be translated into the clinical factors concerning hemodynamics. We consider that patients with pulmonary vascular resistance of less than 10.6 units . m2, and pulmonary arterial mean pressure less than 51 mm Hg, are suitable candidates for complete surgical repair in TGA, if more than 6 months of age. Thus histologic assessment of PVD in a lung biopsy as an indication for total correction of TGA with pulmonary hypertension appears to be useful in patients who are in borderline hemodynamic condition or in whom the hemodynamics could not be evaluated although pulmonary hypertension was suspected.

Autopsy↗
PubMed1980

Severity of PVD.

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Child, Preschool↗
PubMed1979

Quantitative evaluation of hypertensive pulmonary arterial change.

A new method to quantitatively evaluate pulmonary arterial change in pulmonary hypertension is presented in this paper. Hypertensive pulmonary arterial changes are classified into four grades according to severity and a score from 1 to 4 is given to each arterial change according to the grading. An index of pulmonary vascular disease is then defined as a relative mean value of all scores. It is concluded that this index accurately expresses the grade of pulmonary arterial change in the whole pulmonary arterial system in any given case and makes possible a detailed statistical analysis of large numbers of cases.

Adult↗
PubMed1976

Quantitative analysis of pulmonary vascular disease in complete transposition of the great arteries.

Forty autopsy cases of complete transposition of the great arteries (TGA) and 22 autopsy cases of ventricular septal defect (VSD) were analyzed histologically for evidence of vascular damage due to pulmonary vascular disease (PVD). Positive correlations were generally observed between an index of pulmonary vascular disease (IPVD) and blood pressure of pulmonary circulation. No significant difference in IPVD was found between TGA and VSD in the first five months of life, when cases of each disease were compared at similar blood pressure levels. After that age, however, IPVD was much higher in TGA, and particularly severe PVD in this disease was demonstrated histologically. Morphometrical analysis of the pulmonary artery revealed hypertrophy of the muscular cost in response to elevated blood pressure. However, the progress of medial hypertrophy was retarded in TGA in the first five months, and medial thickness in arteries of cases of TGA older than five months was only 70% of that in VSD at the same blood pressure levels. Suppression of this process of reinforcement of the arterial wall in response to the stress of high pulmonary pressure was regarded as one of the important factors precipitating severe pulmonary vascular disease in transposition of the great arteries.

Adolescent↗
PubMed1975

Muscle fiber orientation in normal and hypertrophied hearts.

Muscle fiber orientation in the left ventricular myocardial layer was histometrically estimated in normal, concentric and eccentric hypertrophied hearts. The angle of inclination of muscle fibers from coronal section was largest in the innermost and outermost zones and was progressively diminished toward the middle layer in all the hearts. In the inner layer, the inclination was depressed in eccentric hypertrophy, while there was no difference in fiber orientation in the outer layer. Concentric hypertrophy proved to be an intermediate stage between the normal heart and eccentric hypertrophy, and no opposite behavior was found in the arrangement of heart muscle fibers. The results supported the following view on the mechanism in the activity of hypertrophied hearts. Cardiac hypertrophy is a common accommodation process to increased load, regardless of the difference in the macroscopical shape. In hypertrophy, the ventricular cavity is inevitably enlarged. Consequently, the tension exerted on the ventricular wall on account of intraventricular pressure increases, and the contractile force required from a unit thickness of the ventricular wall is enhanced. The muscle fibers meet this increased demand by starting contraction from an over-stretched state and by ceasing its activity after smaller shortening than in the normal heart.

Cardiomegaly↗
PubMedDate not supplied

Diagnostic efficacy and validity of the ThinPrep method in cervical cytology.

OBJECTIVE: To examine the efficacy of the ThinPrep method, an automated, fluid-based technique for the collection and preparation of exfoliated and aspirated cells in cervical cytology. STUDY DESIGN: A total of 251 patients participated. From each patient a sample was obtained by scraping with a wooden spatula, split and prepared with both conventional Papanicolaou and ThinPrep methods. In the ThinPrep processor, epithelial cells were homogenized in a vial of preservative solution and randomly sampled onto a microscopic slide. From a single vial of sample suspension a series of 10 ThinPrep slides of the same quality were made. All cells were concentrated within an approximately 20-mm-diameter circle in a uniform, thin layer on the ThinPrep slide. RESULTS: Twenty-five percent of the screening area, 10% of the epithelial cells observed and 50% of the screening time were required to arrive at a final diagnosis as compared with the Papanicolaou smear. Virtually complete concurrence was ascertained between the Papanicolaou and ThinPrep diagnoses, for direct agreement of 95.3% and agreement within one diagnostic grade of 99.5%. CONCLUSION: An overall improvement was ascertained in the preparation of microscopic slides and the recognition of abnormal cells with the ThinPrep method.

Female↗
PubMedDate not supplied

Comparative ultrastructural study of atypical adenomatous hyperplasia and adenocarcinoma of the human lung.

Atypical adenomatous hyperplasia (AAH) of the human lung is considered a possible precursor of pulmonary adenocarcinoma. However, its true biological significance remains to be clarified. The authors studied the ultrastructure of AAH in surgically resected lungs and compared it with that of coexisting adenocarcinoma in an effort to define the characteristic features of AAH. Ultrastructurally, AAH possessed oval to irregular nuclei with high nucleo-cytoplasmic ratio and large nucleoli. Development of cytoplasmic organelles was generally poorer in AAH than in adenocarcinoma. However, these differences became less apparent as the degree of atypia of AAH advanced. Both lamellar bodies and electron-dense granules were found in AAH as well as in adenocarcinoma. These results suggest a close relation of AAH with adenocarcinoma of type 2 pneumocyte or Clara cell type. Further, the results of immunohistochemical studies for surfactant apoprotein A, urine protein 1, cytochrome P-450s, CEA, p53, c-erbB-2, Ki67, and bcl-2 well reflected the ultrastructural findings. These results suggest, in accordance with previous studies, that AAH is a lesion closely related to adenocarcinoma. Further, AAH shares some characteristics of type 2 pneumocytes and Clara cells, implying that it might be derived from their common precursor.

Adenocarcinoma↗
PubMedDate not supplied

c-erbB-2, p53 protein expression and steroid hormone receptors in breast carcinomas: an immunohistochemical study.

p53, c-erbB-2 protein, steroid hormone receptors, and their correlation with clinicopathologic features were investigated in 70 primary breast carcinomas. All markers were measured immunohistochemically on paraffin sections. Altered p53 expression was found in 27.1% of cases and was associated with negative estrogen receptor status. p53 immunostaining was correlated weakly with histologically lymphatic vessel invasion of carcinoma. c-erbB-2 protein overexpression was seen in 48.6% of cases. A trend was observed in the correlation between c-erbB-2 immunostaining and regional lymph node metastases. Estrogen receptor status was not associated with any histologic or clinical parameters, whereas progesterone receptor status was associated with lymph node metastasis and histologically lymphatic vessel invasion of cancer. PgR status, p53 and c-erbB-2 immunostaining may prove to be an additional criterion in histologic diagnosis of breast cancer.

Adult↗