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Biomedical subjects

F Tympner

Publications and source records attributed to F Tympner.

At least 19 recordsLinked to original sources
PubMed1986

[Study of the correlation of sonographic and scintigraphic results in measuring stomach emptying].

"Stomach cockade" can be readily imaged sonographically, so that it has also been possible to carry out studies of gastric motility or measurements of gastric emptying times of fluids. However, the results of measurements should be verified by reference methods using new investigation techniques. For this reason, we measured synchronously by sonography and scintigraphy the emptying of test fluids from the stomach in patients with diabetes mellitus and suspected gastroparesis. We found a correlation of the two methods of measurement, so that sonographic measurement can be regarded as confirmed by scintigraphy as a reference method.

Adult↗
PubMed1986

The treatment of chronic recurrent pancreatitis with depot secretin--a preliminary report.

Increased viscosity and raised lactoferrin, trypsin and protein concentrations in selectively aspirated pancreatic secretion, prompted us to try depot secretin therapy in patients with advanced chronic recurrent pancreatitis without pancreatic duct obstruction or pancreatic pseudocysts. The idea behind this approach was that it might "wash out" the sticky, protease-rich secretion. In a randomized double-blind trial we administered depot secretin at doses of 800 CU by subcutaneous injection twice daily for 7 days. Pancreatic secretion from the treatment group had significantly lower viscosities and lactoferrin and trypsin concentrations than in the placebo group. There was also significant pain relief. Depot secretin therapy appears to offer an alternative approach to the management of advanced chronic recurrent pancreatitis without pancreatic duct obstruction or pseudocysts.

Amylases↗
PubMed1984

[Sonography of gallbladder kinetics during cholagogue therapy].

Sonography of gallbladder kinetics shows that a cholagogue exercising a spasmolytic action counteracts the periodic voiding of the gallbladder or even induces an increase in volume of the gallbladder in healthy persons and in patients with cholecystolithiasis. This effect cannot be seen in chronic cholecystitis.

Aged↗
PubMed1982

[Effect of secretin and gabexate-mesilate (synthetic protease inhibitor) on serum amylase level after ERCP].

Complication rate of ERCP is about 2%, mortality rate 0,2%. In about 1% acute pancreatitis or recurrency of chronic pancreatitis occurs. In 20 to 73% a rise of serum amylase is noted without clinical symptoms. In a randomized trial the influence of secretin and gabexate-mesilate (synthetic protease inhibitor) on ERCP-correlated complications was analyzed. Gabexate-mesilate caused a significant decrease of ERCP-induced hyperamylasemias, whereas secretin showed no effect.

Alkaline Phosphatase↗
PubMed1982

[Sonographic measurement of gastric emptying time].

Sonography, as a non-invasive procedure, may be used also for studying the gastric emptying time. After 250 ml of a liquid test meal the gastric emptying time was determined in 20 subjects. In each subject the applied test meal could be traced in the prepyloric antrum. When examined at 8.00 a.m. the fluid had left the stomach after an average time of 8.3 min. During the day the emptying time increased to 10.8 min. A second examination on another day after application of 30 mg metoclopramide revealed significantly lower gastric emptying time. Ultrasonography may therefore be used as a sensitive non-invasive method for studying the gastric emptying rate in the fasting state and under pharmacological stimulation.

Gastric Emptying↗
PubMed1982

[Ultrasound measurement of gastric emptying time values].

Sonography, as a non-invasive procedure, may be used also for studying the gastric emptying time. After 250 ml of a liquid test meal the gastric emptying time was determined in 20 subjects. In each subject the applied test meal could be traced in the prepyloric antrum. When examined at 8.00 a.m. the fluid had left the stomach after an average time of 8.3 min. During the day the emptying time increased to 10.8 min. A second examination on another day after application of 30 mg metoclopramide revealed significantly lower gastric emptying time. Ultrasonography may therefore be used as a sensitive non-invasive method for studying the gastric emptying rate in the fasting state and under pharmacological stimulation.

Antiemetics↗
PubMed1981

[Therapy of gastrointestinal disorders due to oral rheumatism therapy. Effect of bromopride on antirheumatic agent-induced functional reduction in the gastric mucosa barrier].

Non-steroid antirheumatic agents inhibit the synthesis of prostaglandins to an extent which depends upon their respective chemical composition. The result of this inhibition is a reduction in gastric mucosal perfusion, a limitation of cytoprotective factors, and an enhanced back diffusion of H+-ions into the mucosal cell. The function of the gastric mucosal barrier is restricted and a reduction in the measurable electric potential between the gastric serosa and mucosa ensues. Adjunctive therapy with bromopride (Cascapride) improves this reduction in gastric potential difference induced by the antirheumatic agent, and alleviates the gastrointestinal symptoms brought on by the antirheumatic drug.

Anti-Inflammatory Agents↗
PubMed1981

Selectively aspirated pure pancreatic secretion. Viscosity, trypsin activity, protein concentration and lactoferrin content of pancreatic juice in chronic pancreatitis.

The viscosity, trypsin activity, protein concentration and lactoferrin concentration in selectively aspirated, pure pancreatic secretion uncontaminated by bile, were determined in 46 patients with chronic pancreatitis and compared with the values obtained in 39 control subjects. The viscosity was measured using a modified capillary viscosimeter, the trypsin activity and the protein concentration using photometry, and the concentration of lactoferrin employing a new standard. It was found that in chronic pancreatitis, viscosity, trypsin activity and lactoferrin concentration was also found to be increased, but the differences were not significant. The results of this examination support the hypothesis that precipitation of protein-containing material in the pancreatic ducts, delayed outflow of secretion and premature activation of trypsin are pathogenically important factors in chronic pancreatitis.

Adult↗
PubMed1981

[Influence of various non-steroid antirheumatic drugs on the electric potential between the gastric serosa and mucosa (author's transl)].

Non-steroid antirheumatic drugs inhibit the synthesis of prostaglandin, which results in a reduction in the efficacy of the gastric mucosal barrier. The transmural electric potential difference of the stomach wall would appear to be a useful criterion for mucosal barrier function. After 4 weeks of treatment with Indomethacin, Azapropazpone, Diclofenac or Phenylbutazone, a significant reduction in the gastric potential difference as compared with the pre-treatment measurement was observed. Accordingly, non-steroid antirheumatics give rise to a reduction in the functional efficacy of the mucosal barrier.

Anti-Inflammatory Agents↗
PubMed1979

[Chronic pancreatitis: diagnostic value of endoscopic retrograde pancreaticography, of pancreatic sonography, and of secretin-pancreozymin test corrected for volume losses (author's transl)].

Endoscopic retrograde pancreaticography (ERP) and secretin-pancreozymin test corrected for losses (SP test) were performed in 153 patients suspected to have pancreatic disorders in order to evaluate diagnostic significance of these procedures. Pancreatic sonography was done in addition in 110 of these patients. If pancreatic excretion was normal, ERP results turned out to be normal in the same patients as well. SP test involves rather extensive laboratory work-up, but it does yield the most precise results as far as diagnosis of chronic pancreatitis is concerned. For this reason, and because of the possible complications caused by ERP, ERP should be applied only, when surgery is considered. Results of SP test and sonography coincided rather well. Therefore, sonography, not doing any harm to the patient, does have its place in the diagnosis of chronic pancreatitis.

Cholecystokinin↗
PubMed1977

[Analysis of pancreatic function. Determination of fecal chymotrypsin and the secretin-pancreozymin test. Comparative study].

Fecal chymotrypsin determination and secretin-pancreozymin test with volume-loss corrected were carried out intra-individually on 57 clinically normal test subjects and 51 patients with chronic pancreatic disease. A good correlation could be established in every case between the chymotrypsin activity in stool and the chymotrypsin output in the duodenal aspirate. False-positive chymotrypsin activity was not to be found in healthy subjects. On the other hand, however, the chymotrypsin activity in stool compared with the result of the secretin-pancreozymin test was found to be false negative in 21% of all patients with chronic pancreatic disease (some or all parameters pathological). In patients with a clear deficiency in the exocrine function of pancreas (all parameters pathological) the chymotrypsin activity was nevertheless seen to be false-negative in only 9.9% of the cases. Thus the fecal chymotrypsin determination can be used as screening test for the clearly reduced pancreatic exocrine insufficiency.

Adult↗
PubMed1976

Effects of 13-nle-motilin on salivary, gastric, and pancreatic secretions in man.

Salivary, gastric, and pancreatic secretory responses to intravenous 13-norleucine-motilin (13-nle-motilin), a synthetic analog of motilin and biologically equivalent to the natural polypeptide, were studied in healthy volunteers. 13-nle-Motilin in doses of 100 ng/kg body wt/hr significantly stimulated gastric pepsin output, while H + secretion and serum gastrin levels remained unchanged. Enhanced pepsin secretion was not accompanied by an increase in gastric secretion of cyclic 3', 5'-adenosine monophosphate, nor did gastric mucosal levels of the cyclic nucleotide rise. A dose of 13-nle-motilin, which stimulated gastric pepsin output, did not exert any significant effect on salivary and pancreatic secretions.

Adult↗