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Biomedical subjects

F Tympner

Publications and source records attributed to F Tympner.

33 records · Page 2Linked to original sources
PubMed1976

[The function of the hydrokinetic and ekbolic pancreas after acute pancreatitis].

Thirteen patients were investigated 3-4 weeks (I. examination) and 3-5 months (II. examination) after the ceasing of the signs symptoms of an acute pancreatitis concerning their hydrokinetic and ekbolic pancreas-functions. In addition, the pancreatic ducts were demonstrated by ERCP. Reduction of the secretion were shown in 31% at the I. examination and in 23% at the II. examination. There were significant differences in the outputs of bicarbonate, trypsine and chymotrypsine compared to healthy test persons at the I. examination. At the II. examination, however, no significant differences could be observed compared to healthy test persons. The exocrine function of the pancreas was getting worse during the interval between the I. and II. examination in 2 cases but it became normal in 5 cases. Pathological alterations at the pancreativ-duct-system were not demonstrable shown at all.

Acute Disease↗
PubMed1975

[Pancreatic response to graded doses of synthetic secretion: comparison between intravenous and pernasal administration in man].

The response of the human pancreas to varying doses of pure synthetic secretin administered intravenously and, for comparison, 8 days later in the form of snuff was examined, intraindividually, in 10 healthy test subjects. After intubation of the stomach and duodenum and continuous instillation of radioactive vitamin B12, the recovery rate of the marker substance was measured in duodenal aspirates and employed to compute the pancreatic bicarbonate and enzyme outputs. The dose-response relationship between pancreatic bicarbonate production and varying doses of synthetic secretin administered intravenously and in the form of snuff, was good. The pancreatic response to a dose of secretin snuff was only about 1/25 of the response obtained with the same dose of secretin injected intravenously. The level of the pancreatic enzyme output remained relatively uninfluenced by varying doses of synthetic secretin.

Administration, Intranasal↗
PubMed1975

Exocrine pancreatic function in juvenile diabetics.

In 11 juvenile diabetics and 13 control subjects, the secretin-pancreozymin test was performed. Duodenal-volume losses were corrected by use of radioactive vitamin B12 as marker substance. As compared to normal subjects, juvenile diabetics had significantly decreased pancreatic outputs of amylase, trypsin, chymotrypsin, and to a lesser degree, of bicarbonate. Clinical evidence of disease of the exocrine pancreas was missing. There was no discernible relationship between the abnormality of external pancreatic function and the duration of diabetes mellitus or the dose of insulin required. Possible factors that may be responsible for the exocrine deficiency of the pancreas in juvenile diabetics are discussed.

Adult↗
PubMed1975

[Carbohydrate administration and electrolyte balance in patients under intensive care].

A twenty-four percent solution of carbohydrates 0.2 g/kg/h consisting of fructose, xylit and glucose in a 2:1:1 ratio and an aminoacid solution 0.03 g/kg/h were given to 13 patients of the internal medicine intensive care unit. There was an unimportant loss of carbohydrates, only, with but few exceptions, i.e. a loss of 11% in 3 patients. The results demonstrate that the carbohydrates of the combined solution become utilized independent of each other. The balance of water, sodium, potassium and magnesium were not only negative but also positive. The elimination of calcium was between 1-19 mval/24 h, of phosphate between 0.6-8.7 mval/24 h.

Carbohydrates↗
PubMedDate not supplied

The function of the exocrine pancreas after exogenous and endogenous stimulation in Billroth II patients.

Maldigestion phenomena in patients subjected to a Billroth II (B II) operation are in part attributed to an atrophy of the pancreas due to inactivity. In order to investigate this, a Lagerlöf tube was introduced under endoscopic control into the afferent loop, and the function of the exocrine pancreas studied after endogenous and exogenous stimulation. During endogenous stimulation of the exocrine pancreas by means of a Lundh test meal, no significant differences in the secretory pattern of the Billroth II patients as compared with healthy test subjects were found. In contrast, during exogenous stimulation, the output of trypsin and chymotrypsin in healthy subjects was significantly greater than in the B II patients. Since, in comparison with maximal stimulation, the endogenous secretin released by the jejunal mucosa in response to the intake of food, effects only approximately 25% of the bicarbonate production and endogenous pancreozymin effects some 50% of the enzyme output, the maldigestion phenomena observed in B II patients are inpart understandable.

Adult↗
PubMedDate not supplied

Gastroscopic findings after therapy with non-steroid antirheumatic drugs.

Non-steroid antirheumatic drugs inhibit synthesis of prostaglandins, which gives rise to a reduction in gastric mucosal perfusion and the limitation of cytoprotective factors. Thus, pan-endoscopic follow-up examinations performed after four weeks of treatment with various non-steroid antirheumatic agents also revealed a significantly increased incidence of erosions, ulcers and reflux oesophagitis. After therapy of at least 18 months with non-steroid antirheumatics, incomplete erosions were verified in 35% of the cases, complete erosions in 7.5%, and reflux oesophagitis in 22.5%. Signs of gastro-intestinal intolerance occurred in 70% of the patients treated with antirheumatics drugs.

Anti-Inflammatory Agents↗
PubMedDate not supplied

Duodeno-gastric reflux in gastric ulcer patients in relation to intestinal metaplasia of the gastric mucosa.

Using vitamin B12 labelled with Co58 as an exogenous marker, and bilirubin as an endogenous marker, the duodeno-gastric reflux was determined quantitatively in 13 gastric ulcer patients under basal conditions and under stimulation (1 CU secretin/kg body weight + 1 CU pancreozymin/kg body weight) of the exocrine pancreas; in addition, a histological examination of the gastric mucosa was carried out by taking multiple biopsies from along the greater and lesser curvatures of the stomach. Altogether, a more marked mean duodeno-gastric reflux was found in the ulcer patients than in the 14 control subjects. If, however, the ulcer patients are differentiated in accordance with the results of the histological findings in the biopsy material, it is seen that an increased reflux is found only in those ulcer patients presenting with an intestinal metaplasia in the antrum. Statistically, no increase in the duodeno-gastric reflux can be verified under secretin/pancreozymin stimulation of the pancreas.

Bile Acids and Salts↗