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F V Ona

Publications and source records attributed to F V Ona.

At least 19 recordsLinked to original sources
PubMed1998

Prevalence of Helicobacter pylori in peptic ulcer patients in greater Rochester, NY: is empirical triple therapy justified?

OBJECTIVES: Among patients with peptic ulcer disease, the prevalence of Helicobacter pylori has been reported to range from 80% to 90%. Thus empirical cost-effective therapy has been suggested. We surveyed patients with peptic ulcer disease in Rochester, NY. METHODS: From two teaching hospitals all patients who had duodenal ulcers (DU) and/or gastric ulcers (GU) on esophagogastroduodenoscopy (EGD) with antral biopsy for histology for H. pylori and for rapid urease (CLO) test were included in the study. We examined a total of 160 patients with DU and 145 patients with GU, age range 18-92 yr, obtaining clinical data, race, medication profile, and history of use of nonsteroidal antiinflammatory drugs (NSAIDs). An ulcer was defined if the lesion with loss of mucosal integrity was > or = 0.5 cm, with apparent depth. H. pylori was considered present if CLO test and/or histology were positive for H. pylori. To confirm the reliability of nonuse of NSAIDs, we randomly checked blood samples of 90 such patients from the ambulatory clinic for the presence of salicylates. To identify the sensitivity of the CLO test, we performed a serology test for H. pylori antibody in 100 subjects to compare the CLO test results. Also, 500 CLO test results were compared to the histology results for H. pylori. RESULTS: Among 160 DU patients, 16 were NSAID users with negative H. pylori and excluded from the prevalence study. Of the remaining 144 patients with DU, H. pylori was present in 88 patients (61%). When these data were analyzed according to race, H. pylori was present in 54 (52%) of 104 whites compared to 34 of 40 (85%) nonwhites (blacks, Hispanics, Asians) (p < 0.01). Among 145 GU patients 18 were NSAID users with negative H. pylori and excluded from the prevalence analysis. Of the remaining 127 patients with GU, H. pylori was present in 87 patients (61%). Among them, H. pylori was present in 46 of 87 (53%) whites, whereas 31 of 40 nonwhites (78%) were H. pylori-positive (p < 0.01). Antral histology and CLO test for H. pylori were in agreement in 92% of cases. Serology and CLO test for H. pylori were in agreement in 87% of cases. None of the randomly screened patients, including 16 ulcer patients with negative H. pylori, showed presence of salicylate in blood. CONCLUSION: In greater Rochester, NY, where the majority of our patients with EGD were whites, the prevalence of H. pylori among ulcer patients was lower compared to other regions, particularly among whites. This suggests that an additional causative factor or factors for peptic ulcers may be present. Hence, empirical antibiotic therapy of ulcer patients without confirming the presence of H. pylori may not be justified.

Adolescent↗
PubMed1991

Clonorchis-associated cholangiocarcinoma: a report of two cases with unusual manifestations.

Two cases of Clonorchis-associated cholangiocarcinoma are described along with their cholangiographic features to illustrate the spectrum of pathology ascribed to the injurious effects of the flukes on the bile duct epithelium. This includes adenomatous hyperplasia, extensive fibrosis, and carcinoma. The first case was also complicated by hepatic abscesses, left hepatic lobar atrophy, gastrobiliary and biliarocutaneous fistulae. The second case features an unusually dilated pancreatic duct containing pancreaticoliths that was found later to consist of hyperplastic bile duct epithelium, presumably carried by worm migration in the biliary tree. Liver sections from both patients showed typical features of hepatic clonorchiasis with the cancer. A knowledge of the wide spectrum of clinical presentation of clonorchiasis, particularly cholangiocarcinoma, might aid Western physicians in averting this serious sequela through prompt eradication of the helminthic infection and early recognition and treatment of its complications.

Adenoma, Bile Duct↗
PubMed1984

Gallbladder disease: risk factor for colorectal carcinoma?

The relation between gallbladder disease and the risk of colorectal carcinoma (CRC) is examined in light of 864 consecutive adult postmortem examinations analyzed for significant associations between the state of the gallbladder (normal, cholelithiasis, and cholecystectomy) and the presence of colorectal carcinoma. Our findings supported the known association between female sex and gallbladder disease (p = 0.02) and revealed a significant association between cholelithiasis and/or cholecystectomy and colorectal cancer (p less than 0.02). The frequency of CRC was higher in patients who had a cholecystectomy than in those still with stones, but this difference was not statistically significant. The data suggests a sex-linked dependence between the state of gallbladder and CRC. However, the proper statistical test for this dependence was not significant (p less than 0.25), no doubt as a result of the relatively small amount of data for persons with gallbladder disease. We conclude that the state of gallbladder may modify the risk for colorectal carcinoma.

Cholecystectomy↗
PubMed1982

Diagnosis and management of nonspecific colon ulcer.

This report describes seven cases of nonspecific colon ulcers and analysis of the additional 120 cases reported in the literature through 1980. The total current series is compared with the two earlier reviews. Our findings showed that nonspecific colon ulcers occur in all age groups, predominantly 40 to 60 years, with slight predilection to female sex. The man clinical manifestations include abdominal pain mimicking appendicitis (50%), lower gastrointestinal hemorrhage (33%), perforation (19%), and abdominal mass (16%). The usual location of the ulcers is the cecum and ascending colon (67%), then transverse, hepatic, and splenic flexures (18%), and descending and sigmoid colon (15%). The diagnosis is best established by colonoscopy. The nonoperative conservative management is probably indicated in the uncomplicated cases with follow-up colonoscopic studies to ensure complete healing. The etiology of this condition is still unknown.

Adult↗
PubMed1981

Gastric sarcoid: unusual cause of upper gastrointestinal hemorrhage.

An unusual presentation of sarcoidosis was noted in a patient who developed severe upper gastrointestinal hemorrhage. The bleeding was attributed to a sarcoid ulcer of the stomach. Serial gastroscopic studies demonstrated complete resolution of the ulcer within five months on conventional antacid therapy. The only residual lesions were gastric mucosal nodularities and moderate hyperemia with granulomas on biopsy. Sarcoidosis was diagnosed by positive Kveim test and abnormal diffusing lung capacity despite a normal chest roentgenogram.

Female↗
PubMed1981

Bleeding gastric telangiectasia. Complication of Raynaud's phenomenon, esophageal motor dysfunction, sclerodactyly and telangiectasia (REST) syndrome.

Anemia and skin telangiectasia were the main presenting features of a patient with Raynaud's phenomenon, esophageal motor dysfunction, sclerodactyly and telangiectasia (REST) syndrome. Diffuse gastric telangiectasia with chronic intermittent blood loss were responsible for the anemia. The multisystemic and progressive character of this collagenopathy in our patient is described and the endoscopic picture is presented. Management difficulties and treatment alternatives are discussed.

Aged↗