Biomedical subjects

Felicia Stefanache

Publications and source records attributed to Felicia Stefanache.

4 recordsLinked to original sources

PubMedDate not supplied

[Absence seizure--recent physiopathologic data].

The progresses in clarifying the normal and pathologic cellular and molecular mechanisms are reflected in the elucidation of the way some of the most common forms of generalized seizure--absence seizures--occur and are produced. Intrinsic properties of the thalamic neurons that give them the ability to release or preserve oscillatory, low-frequency neuronal discharges, and the thalamo-cortical feedback mechanism seem to explain the pathogenesis of absence seizures. The involvement of GABA receptors in the regulation of membrane calcium channels, as well as their genetically-induced changes are new pieces in the pathogenic puzzle.

Animals↗

PubMedDate not supplied

[Acute myocardial infarction with neurological symptoms: clinical and pathologic aspects].

A variety neurological symptoms can be the onset of an acute myocardial infarction. The study includes 96 patients who have undergone necropsies (from 1978 to 2003), hospitalized at the "Sfânta Treime" University Hospital, Iaşi, in the Neurology Clinic. They were admitted for various neurological manifestations: hemiparesis, hemiplegia, aphasia, coma of the 1st degree up to the 4th. Death of these patients was due to acute myocardial infarction in the cases of most of them, even those with significant brain damage. We have taken into account the anatomic pathology of the heart, brain, kidneys and lungs. The prevalence of the factors of cardiovascular risk was considered in our study, as well as the topography of the myocardial infarction. Patients with acute myocardial infarction can present major neurological symptoms with no significant cardiovascular clinical symptoms.

Adult↗

PubMedDate not supplied

[Prospective epidemiologic and clinical observations on the prevalence of risk factors for stroke, performed on 374 inpatients, during the period of June 2001-June 2004].

UNLABELLED: Within the framework of cardiovascular pathology, with an epidemopandemic aspect, the stroke, through its mortality and sequels, represents, worldwide, a major problem of community health. In this context, we present the results of an epidemiological and clinical study, both prospective and interdisciplinary, performed on a sample of 374 inpatients suffering from stroke, hospitalized in the Neurology Ist Clinic of Iaşi, during the period June 2001-June 2004. The characteristics of the studied sample: age--78.8% over 51 years old, sex--53.7% male; residence--51.4% urban; provenance: rural--70.0% (p<0.001); studies: higher education--7.7% ; pensioners--76.2%; passive finding--96.8%; previous hospitalizations for cardiovascular diseases and/or diabetes mellitus: 48.2%; blood groups: OI and AII--86.61%. RESULTS: Risk factors for stroke: 56.6%--BMI > 25; "A" behavior type (Bortner's test)--63.8%; stress: familial--74.1% and occupational--25.9%; excess consumption: alcohol--11.4%; salt--32.8%; tobacco--24.9%; passive smoking--10.8%. Releasing and aggravating risk factors: arterial hypertension (AHT)--55.4% (p<0.001); obesity--12.9%; diabetes mellitus--12.5%. Hereditary antecedents: AHT--46.8%; ischemic cardiopathy and myocardial infarction--15.6%; obesity and dyslipidemia--15.0%; stroke--10.8%. CONCLUSIONS: In this study, the multifactorial and associative etiology of stroke is confirmed once more, and the estimate costs of 1.21 milliard lei, only for the 10-day average hospitalization, for each of the 374 inpatients.

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PubMedDate not supplied

Mechanical ventilation in vascular coma patients.

Vascular coma is one of the leading complications in patients suffering cerebrovascular accidents and it is therefore entirely appropriate that we should consider what critical care has to offer in this devastating disease process. Vascular coma patients need ventilatory assistance; Intubation and mechanical ventilation represent a life saving intervention. As critical care is subjected to progressive changes, careful definition of the role of mechanical ventilation, its types, and the ability of such a form of life sustaining support to affect patient outcome in multi-sided directions is mandatory.

Coma↗