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Biomedical subjects

G A Glezer

Publications and source records attributed to G A Glezer.

At least 37 records · Page 2Linked to original sources
PubMed1989

[Hypotensive effect of hydrochlorothiazide and its combination with triamterene].

A comparative study of the antihypertensive effects of hydrochlorothiazide (HCT) monotherapy and of its combinations with triamterene (T), carried out in 57 patients with Stage II noncomplicated essential hypertension, have shown the best antihypertensive effect of 2 tablets of triampur (TP), containing 12.5 mg HCT and 25 mg T each; 25 mg of HCT have been less effective. Triampur more markedly reduced the systolic arterial pressure (APs) at rest, with the patient lying down. If the drug doses are doubled, TP intake leads to a somewhat more manifest reduction of APs than HCT. The pattern and the degree of orthostatic shifts are virtually unchanged by both the drugs. In exercise test neither TP nor HCT in the afore doses influenced the pattern and degree of the hemodynamic shifts. These results evidence that TP hypotensive effect and the underlying hemodynamic shifts are in fact identical in their pattern and manifestation to the effect of HCT alone and are mainly due to this latter drug.

Antihypertensive Agents↗
PubMed1988

[Effect of various diuretic doses on hemodynamics in patients with hypertension].

Before and after hypothiazide and oxodoline (chlortalidone) given in various dosages, hemodynamic parameters were examined in 132 patients with Stage II hypertensive disease at rest, in the orthostatic position, and during exercise testing on a bicycle ergometer. With either drug, a significant resting fall in systolic BP started at 25 mg, in diastolic BP at 50 mg. The hemodynamic mechanisms by which the diuretics exerted antihypertensive action were decreases in stroke index and cardiac index while specific peripheral resistance remained unchanged or slightly increased. Hypothiazide and oxodoline produced no change in orthostatic circulatory response. During bicycle ergometer testing, the absolute systolic BP value was significantly less only when hypothiazide was given in a dise of 100 mg, oxodoline--50 and 100 mg and only when exercise intensities were low (25 W). A significant drop in diastolic BP occurred only at 100 mg of oxodoline and only at low exercise intensities. The diuretics were found to have no pronounced action on the hemodynamic profile during physical exercise.

Antihypertensive Agents↗
PubMed1986

[Clinical and experimental study of clofelin pharmacodynamics].

Hemodynamic mechanisms of clophelin hypotensive effect were studied in 122 patients with arterial hypertension. In most cases, antihypertensive clophelin therapy did not affect the nature or magnitude of orthostatic and stress-induced hemodynamic shifts. The fact that the fall in perfusion BP was not accompanied with a resting, orthostatic or stress-induced impairment of renal function was a particularly valuable aspect of clophelin treatment. Experimental studies demonstrated that clophelin hypotensive effect was partly due to limited Ca2+ entrance through the slow calcium channels in the cell membrane as well as limited potassium withdrawal during excitation. Single and repeated clophelin administration (0.03-1 mg/kg daily) was shown to depress reproductive capacity in rats of both sexes, due to suppressed blood levels of pituitary gonadotrophin as well as altered gonadal sensitivity to gonadotrophin effects.

Action Potentials↗
PubMed1986

[Hemodynamic changes in healthy persons and in patients with arterial hypertension during hyperventilation].

Hemodynamic changes in response to the hyperventilation test were examined in normal males and females of varying age, and in patients with first- and second-stage essential hypertension, renal arterial hypertension and hypertensive neurocirculatory dystonia. Normal subjects showed increased heart rate (HR) and cardiac index (CI), and lowered specific peripheral resistance in response to hyperventilation, the magnitude of HR and CI changes declining with age. The increase in HR and CI during the test was somewhat more pronounced in patients with essential hypertension as compared to normal subjects, whereas in hypertensive neurocirculatory dystonia hemodynamic shifts were similar to those of normal subjects.

Adolescent↗
PubMed1985

[Circulatory system reaction to loading tests in patients with the climacteric syndrome in relation to the phase of the climacteric and the presence of cardialgia].

Female patients with the menopausal syndrome (MS) manifestations showed a steeper increment of diastolic arterial blood pressure (ABP) and heart rate, as compared to normal subjects, in both phases of the menopause, irrespective of whether cardialgia was present or not; moreover, half of the patients showed negative electrocardiographic dynamics. Hemodynamic shifts in response to bicycle ergometry were similar in both menopausal phases and showed steeper increments in ABP and heart rate, as compared to those of normal subjects. Excessive ABP rise in response to exercise is mostly associated with cardialgias. Exercise-related ECG can usually improve or return to normal in premenopausal patients, while ischemic ST depression is associated with postmenopausal conditions. Physical working capacity of premenopausal women is only impaired in the presence of cardialgias, whereas that of postmenopausal women is reduced in the absence of cardialgia as well.

Adult↗
PubMed1985

[Central hemodynamics in chronic alcoholics].

Central hemodynamics were assessed in 86 chronic alcoholic patients in relation to the stage of the disease and the kind of alcoholic dependence. The values of major hemodynamic parameters were shown to depend on both the stage of the disease, and clinical manifestations of abstinence. The abstinence syndrome developing after a 3-5-day abstinence is associated with a gradual transition from eukinetic- to hypokinetic-type circulation, as the disease progresses. Hemodynamic shifts following recovery from acute delirium tremens are not related to the stage of the disease, and tend to hypokinetic-type circulation. During remission, hemodynamic parameters approach those of normal subjects.

Adult↗