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Biomedical subjects

G A Glezer

Publications and source records attributed to G A Glezer.

At least 55 records · Page 3Linked to original sources
PubMed1984

[Blood circulation in healthy inhabitants of the arid zone of Turkmenistan. Report 2. Use of controlled exercise test in persons with good and insufficient adaptation to high environmental temperature].

Bicycle ergometry was performed in 143 normal male residents of Ashkhabad in different seasons of the year. In cool weather, the direction and magnitude of hemodynamic response to exercise in Ashkhabad residents were similar to those of people from milder climatic zones. In summer, exercise-related systolic and diastolic blood pressure and the stroke index were smaller as compared to the respective values of the cool season. During the transition period (i.e. first hot summer days), blood pressure and the stroke index were the lowest, and the heart rate was somewhat increased. In hot weather, exercise produced a greater reduction in the circulating blood volume and a greater increase in the hematocrit value. Thirteen (9%) subjects with poor tolerance of hot weather were identified in the screened population. In these, hemodynamic shifts were similar to those observed in most normal subjects during inadequate acclimatization of the first hot summer days.

Acclimatization↗
PubMed1983

[Clinico-experimental study of the new antihypertensive preparation abletol (labetalol)].

Albetol treatment was administered to 31 patients with stable hypertension. The drug produced a drop in the heart rate, cardiac index and a slight decrease of total peripheral resistance, due to albetol simultaneous alpha- and beta-blocking action. There were no marked orthostatic changes. Blood pressure, cardiac index and heart rate values increased to a smaller extent in response to exercise. Experimental studies in the frog atrium showed different effects of Albetol and Propranolol on transmembrane ion currents. Albetol did not affect renal function at rest, nor the pattern of its change under physical stress and in an orthostatic position. It is suggested that albetol alpha-blocking action is predominant in the orthostatic test, while beta-blocking effect prevails during exercise.

Adrenergic beta-Antagonists↗
PubMed1983

[Blood circulation in healthy persons in the arid region of Turkmenia. I. Studies in the supine and orthostatic positions].

The active orthostatic test was used to investigate 164 normal male residents of Ashkhabad during the cool season, 143 in summer and 66 during the transition period, i. e. first hot summer days. During the cool season, the pattern and markedness of orthostatic circulatory shifts in Ashkhabad residents were similar to those observed in moderate climate. In summer, orthostatic drop in systolic BP, cardiac index and circulating blood volume is more pronounced as compared to values of the cool season, while the rise in heart rate and diastolic BP is less pronounced. Orthostatic shifts are the most marked in the first hot days of summer: systolic BP, stroke and cardiac indices drop considerably, whereas diastolic BP and peripheral resistance to blood flow remain unchanged or slightly increase, with heart rate showing the most marked rise.

Adult↗
PubMed1983

[Sex and age-dependent differences in the circulatory response to the exercise test].

The testing of normal males and females of different age revealed no intersexual differences in circulatory response to the orthostatic test. During exercise, female subjects showed lower systolic arterial pressure, cardiac and stroke indices, and greater diastolic arterial pressure, heart rate and peripheral resistance to blood flow, irrespective of their age. Parameters of physical efficiency are higher in males as compared to females. Exercise tolerance decreases with age in subjects of both sexes, the decrease, however, being more pronounced in males.

Adolescent↗
PubMed1982

[Clinical and experimental study of dioxidine. Its antibacterial action].

The effect of dioxidine on the growth of freshly isolated clinical strains of microorganisms with various levels of resistance to antibiotics was studied. It was shown that strains of Ps.aeruginosa not resistant to carbenicillin, chloramphenicol and nalidixic acid were most sensitive to the drug. Similar correlation was found in Proteus strains with various levels of resistance to chloramphenicol. Sensitivity of these organisms to dioxidine did not depend on their resistance to gentamicin, ampicillin and neomycin. The antibacterial effect of the drug is based on inhibition of the synthesis of nucleic acids, the level of DNA synthesis inhibition being the highest. Dioxidine had practically no effect on protein synthesis.

Anti-Bacterial Agents↗
PubMed1981

[Effect of antibiotics on human lymphocyte mitogenesis].

The effect of some antibiotics on in vitro blast transformation of lymphocytes of healthy donors stimulated with phytohemagglutinin was studied. The stimulation level was estimated by incorporation of 3H-thymidine into lymphocytes. It was shown that minocycline had a markedly pronounced inhibitory activity. Chloramphenicol and tetracycline also proved to be active inhibitors. Penicillin, cephalotin and carbenicillin had no effect on lymphocyte mitogenesis. Gentamicin proved to be a rather active stimulator of mitogenesis, especially with the use of a suboptimal concentration of phytohemagglutinin. The method is rather sensitive and informative. It may be used for preliminary determination of the immunotropic properties of drugs and chemical compounds with respect to immunocompetent cells of man.

Anti-Bacterial Agents↗