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Biomedical subjects

G A Glezer

Publications and source records attributed to G A Glezer.

At least 73 records · Page 4Linked to original sources
PubMed1980

[Aspects of hypertension of endocrine and adrenal origin].

The authors discuss the results of observation of 269 patients with adrenal arterial hypertension 247 of whom underwent operation. The malignant hypertension syndrome developed in 39% of the patients. It is presumed that its development was caused by the combination of adrenal and renal affections as well as by specific hormonal shifts: relative norepinephrine hyperproduction and reduced intensity of catecholamine metabolism. In all groups of the patients with the malignant hypertension syndrome, a higher daily excretion of aldosterone and increased blood renin activity were also found. The character of the drug therapy and the late results of surgical treatment are discussed. A new variant of hyperaldosteronism, dexamethasone-inhibited form of aldosteroma, is described.

Adrenal Gland Diseases↗
PubMed1980

[Effectiveness of nonachlazine in ischemic heart disease under ambulatory conditions].

The efficacy of nonachlazine given in a daily dose of 90--180 mg was studied in 82 out-patients with ischemic heart disease. The drug had no marked effect on the frequency of angina pectoris attacks and the number of times that nitroglycerin had to be taken; no essential changes were noted in the pulse rate and arterial pressure level. A certain increase in the tolerance to physical loan was found. The authors emphasize that in evaluating the effect of a drug on ischemic heart disease, it is necessary to take into account the cyclic course of the disease and the effect of nonmedicamentous factors (weather changes, temporary incapacity for work, etc). The authors do not confirm the conclusion of other researchers who claim that a daily dose of 90--180 mg of nonachlazine is highly effective.

Adult↗
PubMed1978

[Effect of thyrocalcitonin on the functions of the intact and hypertrophied myocardium].

Examination of 20 individuals without any pathological conditions of the cardiovascular system and 8 patients with myocardial hypertrophy has shown that the hypocalciemic hormone of the thyroid gland thyrocalcitonin has a certain negative inotropic effect and does not possess chrono- and dromotropic affects. The mechanism of the cardiac effect of thyrocalcitonin is evidently due to its effect on the metabolism of calcium and its transportation in the myocardial structures.

Adult↗
PubMed1978

[General hemodynamics and kidney function in hypertension in pregnant women].

The indices of general hemodynamics and renal function were studied in 362 pregnant women (healthy and those suffering from hypertensive disease, glomerulonephritis or nephropathy) and in 20 healthy but not pregnant women. It was found that the hypokinetic type of circulation developed in glomerulonephritis and nephropathy in pregnant women and that the hyperkinetic type changes to eu- and hypokinetic types in pregnant women suffering from hypertensive disease. In all variants of hypertension in pregnancy, the renal blood flow and glomerular filtration reduce, while the resistance to the blood flow in the vessels of the kidneys increases. The role of the sympathetico-adrenal and the renin-aldosterone systems in the changes in hemodynamics and renal function in healthy and sick pregnant women was studied. An opinion is voiced that increased sensitivity of the vascular receptors to vasoactive substances is very important.

Blood Volume↗
PubMed1978

[Effect of pyridoxylate on the intensity of changes in the internal organs and skeletal musculature of rats under considerable physical loading].

Under considerable physical load, marked enzymopathy, increased permeability of cellular membranes with the involvement of cellular and subcellular structures develop in the myocardium, skeletal musculature and viscera of rats. Administration of pyridozylate decreases the intensity of damage reactions and normalizes to a certain degree the structure of cellular and subcellular elements of tissues. This indicates the advisability of the employment of the cell respiration regulators under conditions of general and tissue hypoxy and metabolic shifts.

Animals↗
PubMed1977

[Pyridoxylate treatment of athletes with chronic myocardial overexertion].

Twenty-five highly skilled athletes with chronic stage I or II myocardial overexertion were examined. It was established that pyridoxilate produced a good therapeutic effect despite the fact that the athletes went on with their sport activities. On the background of the treatment the ECG and the indices of cardio- and hemodynamics and gas exchange improved and the physical efficiency grew. No essential difference was found in the effectiveness of pyridoxilate when it was administered by different routes. Side-effects of treatment were not observed.

Blood Pressure↗
PubMed1976

[Use of pyridoxylate for treating chronic coronary insufficiency].

A total of 49 patients with chronic ischaemic heart disease (38 of whom had previously survived myoca dial infarction) were treated with Piridoxylate administered intramuscularly and orally. The treatment resulted in an improvement of the state of 2/3 of the patients, positive ECG shifts, improvements of cardio- and haemodynamics at rest and under physical exercises. In half of the patients an increased tolerance of physical exercises was noted. No side-effects of Piridoxylate therapy were observed.

Administration, Oral↗
PubMed1976

[Presence of the blood depot in orthostatic position and after physical exertion].

In healthy individuals and in patients with essential hypertension in the orthostatic position and on physical effort an insignificant reduction in the volume of the circulating blood and of the packed cell volume were in evidence; this being due to the outflow of the liquid part of the blood into the tissues. Even in instances of a well-marked orthostatic hypotonia, during medication with sympatholytic agents in particular, the circulating blood volume in the orthostatic position does not show any significant change. The results obtained by the authors and an analysis of the published data suggest that all of the blood is in circulation with none of it being repository or leaving the depot either in the orthostatic position or on physical effort.

Antihypertensive Agents↗
PubMed1976

Effects of propranolol on haemodynamic changes and gas exchange at rest, in orthostasis, and on exercise in patients with arterial hypertension.

The effects of propranolol on the circulation and respiration were studied in 38 patients with essential hypertension and symptomatic renal hypertension. The hypotensive effect of propranolol was associated with decrease in the cardiac index and heart rate; the peripheral vascular resistance moderately increased, and the circulating blood volume and haematocrit value showed no essential changes. Besides, a prolongation of the pre-ejection period, the decrease of intrasystolic index, an increase in the myocardial wall-tension index, and a retardation of the elevation rate of the intraventricular pressure were observed. After propranolol medication, on transition into the vertical position the heart rate showed a less marked acceleration; the remaining haemodynamic parameters changed in orthostasis as they had done before the treatment. After propranolol medication, on exercise the systolic and mean arterial pressures, heart rate, and cardiac output exhibited lesser increases than before the treatment, whereas the circulating blood volume, diasolic pressure, and peripheral vascular resistance increased just as they had done before the treatment. At rest, during propranolol medication there appeared a certain tendency to decreased oxygen uptake; in orthostasis the degree of increase in oxygen uptake did not change by the action of propranolol. Besides, propranolol did not alter the blood-plasma levels of lactic acid and pyruvate at rest and did not essentially change the oxygen uptake during exercise. The level of lactic acid and the lactate/pyruvate quotient in plasma during exercise increased slightly less after than without propranolol.

Blood Volume↗
PubMed1976

[Myocardial changes in rats after considerable physical exertion and the effect of pyridoxilate on the severity of these changes].

Under significant physical exercises the myocardium of rats displays distinct enzymopathy, increased permeability of the cell membranes with a considerable dispersion of plasma proteins and damage to the ultrastructures of the myocytes. The employment of pyridoxilate reduces the severity of the damaging reaction, and to some extent normalizes the structure of the cellular and sub-cellular elements of the myocardium. This indicates to the prospects of using the regulators of cellular respiration under total and tissue hypoxia.

Animals↗
PubMed1975

[Effect of propranolol on hemodynamic shifts and respiration during physical exertion in patients with hypertensive disease].

An examination of 25 patients with hypertensive disease of the I-II stage proved that following propranolol treatment the systolic and mean arterial pressure, the rate of cardiac contractions and the minute blood volume accrue on physical effort to a lesser extent, and the circulation time, diastolic pressure and peripheral resistance ot the blood flow-to the same degree as before the medication. Changes in the phasic structure of the left ventricle of the heart in physical exertion are less marked than they were prior to the treatment. Propranolol does not materially change the level of the oxygen consumption on effort; the lactic acid level and the ratio lactate/pyruvate in the blood rise against the background of the medication with this drug to a some-what lesser degree than before the treatment.

Blood Pressure↗
PubMed1975

Changes in general haemodynamics and renal function during exercise in patients with arterial hypertension.

Basic haemodynamic parameters were measured in 58 men in various stages of essential hypertension, 18 patients with hypertensive form of chronic glomerulonephritis, and 23 practically healthy persons during graded exercise in the supine position on a bicycle ergometer for 30 minutes. During exercise, the systolic pressure rose in all persons investigated, whereas the diastolic pressure markedly increased only in patients with arterial hypertension. The cardiac index increased, according to the intensity of the exercise equally in the healthy persons and in patients in early stages of essential hypertension; a lesser increase in the cardiac index was observed in patients in late stages of hypertension and in those with chronic glomerulonephritis. The increase in the cardiac index during exercise is essentially due to an increase in the heart rate; the stroke index increases only slightly, and in later stages of essential hypertension even decreases. The total peripheral resistance diminishes during exercise, but less so in patients with arterial hypertension in whom it is distinctly higher than in healthy persons. The circulating blood volume decreases during exercise in consequence of a decrease in plasma volume, whereas the haematocrit value increases. Renal blood flow and glomerular filtration decrease during exercise, both in healthy untrained persons and in patients with arterial hypertension. In patients in late stages of essential hypertension and in those with glomerulonephritis, the above parameters decrease more markedly and at lower exercise intensity than in healthy persons.

Blood Pressure↗