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Biomedical subjects

G A Lawler

Publications and source records attributed to G A Lawler.

6 recordsLinked to original sources

Cerebral toxoplasmosis and lymphoma in patients with acquired immunodeficiency syndrome.

16 Patients with central nervous system (CNS) complications of the acquired immunodeficiency syndrome (AIDS) are described. All patients were male homosexuals. The most common demonstrable lesion in the parenchyma was toxoplasmosis, which produced an area of focal oedema, usually containing a central zone of nodular or ring-shaped enhancement. Cerebral atrophy was also a common finding. One patient had diffuse peri-ventricular lymphomatous infiltration, and a further two patients had both cerebral toxoplasmosis and lymphoma. A delayed "double dose" contrast examination appears to be the most accurate method of outlining the total extent of CNS disease in these patients.

Acquired Immunodeficiency Syndrome↗

Use of computed tomography in the percutaneous drainage of abdominal abscesses.

The technique of computed tomographic guided drainage of abdominal abscesses is simple, and is becoming increasingly available. Obvious advantages include the avoidance of general anaesthesia and major surgery. Three illustrative cases of the drainage of abscesses in different locations are presented together with a description of the technique.

Abdomen↗

CT features of rounded atelectasis of the lung.

Rounded atelectasis is an uncommon but increasingly recognized benign form of peripheral lung collapse. The three patients described here had pleural-based lung masses considered initially to represent carcinoma. On computed tomography, a characteristic appearance of eight major and five minor signs of rounded atelectasis of the lung were found. In conjunction with other radiologic evaluations, these allowed the patients to be confidently managed without exploratory thoracotomy.

Adult↗

Nuclear magnetic resonance (NMR) imaging in Wilson disease.

Nuclear magnetic resonance (NMR) scans of the head and liver were obtained in 13 patients with Wilson disease, and the results were compared with computed tomography (CT). Twelve age and sex matched normal controls were also scanned with NMR. The subjects were scanned using repeated free induction decay (RFID), inversion-recovery (IR), and spin-echo (SE) sequences. The IR scans of the brain provided excellent anatomical localisation while SE scans highlighted pathological areas. Within the brain, NMR demonstrated abnormalities in two patients with normal CT scans. More extensive involvement was shown with NMR in three additional cases. In the liver, NMR and CT showed similar abnormalities of morphology. T1 values were within the normal range in all cases, including three patients with high liver copper levels at the time of NMR examination.

Adolescent↗

CT-guided percutaneous biopsy.

Percutaneous biopsy procedures using current imaging methods are becoming increasingly popular. The result of a percutaneous biopsy may lead to a total rejection of surgery, and dictate appropriate palliative therapy in a patient with incurable malignant disease; in others, it will allow more precise preoperative planning. The techniques of percutaneous computed tomographic biopsy procedures is discussed, along with its advantages and disadvantages in comparison with other imaging methods.

Biopsy, Needle↗