Biomedical subjects

G A Oleĭnikova

Publications and source records attributed to G A Oleĭnikova.

3 recordsLinked to original sources

PubMed1989

[Study of the process of inactivating oleandomycin phosphate preparations].

Ageing of oleandomycin preparations was studied. Certain biologically inactive components accumulating on storage of the preparations were isolated and investigated. A scheme for ageing of oleandomycin phosphate preparations is described. The scheme includes cleaving up of the water molecule at C11 and cleaving by the epoxide ring at the early stages and hydrolysis by the glycoside bonds at the later stages.

Chemical Phenomena↗

PubMed1986

[Epoxy ring scission in the oleandomycin molecule during aging].

Opening of the epoxide ring in the molecule of oleandomycin phosphate in the process of its aging was shown to be possible by the data of the analysis. Certain correlation between the "glycol" content and drug activity was detected.

Drug Stability↗

PubMed1982

[Isolation and study of the compounds of a peptide nature contained in an oleandomycin preparation].

Marketed oleandomycin phosphate, as well as the International Standard of oleandomycin (Great Britain, the 1st Int. Std., 1964) were studied with a purpose of determining their composition. The components were separated by liquid chromatography on columns with Sefadex LH-20 using 50 per cent ethanol as an eluent. The Lowry method using the biuret test and assays of the amino acids in the hydrolysates were used to show for the first time that marketed oleandomycin and its International Standard contained an admixture of the peptide nature. The data of the amino acid assays suggest that the admixture and oleandomycin is a fixed complex (adduct).

Amino Acids↗