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Biomedical subjects

G A Vilkov

Publications and source records attributed to G A Vilkov.

At least 37 records · Page 2Linked to original sources
PubMed1984

[Ultrastructural and biochemical evidence of brain damage by the serum IgG fraction of the blood of schizophrenics].

Using electron microscopic and biochemical studies, the rat brain was examined following the intracisternal administration of IgG obtained from schizophrenics' blood serum. The resultant ultrastructural impairments of the sensorimotor cortex and activation of lipid peroxidation processes were similar to the alterations detected in the brain of the schizophrenic patients. The results suggest that the circulating cerebral antibodies in schizophrenics possess a membranotropic effect and may induce various structural and functional disorders in the central nervous system of these patients.

Animals↗
PubMed1983

[Changes in catecholamine metabolism in the brains of rabbits after treatment with anti-brain antibodies and lithium ions].

The authors studied the changes in the activity of tyrosine hydroxylase and dopamine-beta-hydroxylase (the principal enzymes controlling the synthesis of catecholamines) in the whole brain of rabbits on intracisternal injection of immunoglobulin G isolated from the blood of brain-sensitized dogs or from the serum of schizophrenic humans. Also the changes of the content of principal catecholamines (DOPA, noradrenaline, adrenaline) in the animals brain on intravenous injection of lithium chloride after preliminary treatment of the animals with anticerebral antibodies were studied. The changes of the activity of both enzymes in both series of the experiments appeared to be uniformly directed, the fact, that gives one grounds to regard the mechanisms underlying these disturbances as similar. A positive effect of lithium on the catecholamine metabolism in the rabbit CNS was observed. This makes is possible to recommend the model used in this study for examining the efficacy and mode of action of a number of psychotropic drugs.

Animals↗
PubMed1982

[Dicarboxylic amino acids in brain proteins under conditions of sensitization with brain antigen].

Under conditions of the organism sensibilization with brain antigen there occur changes in amino acid composition of the brain protein fractions. The ratio of negatively charged amino acids to positively charged ones in sharply shifted towards predominance of the negative charge. A conclusion is made that such a brain protein modification activates acid peptide hydrolases and intensifies the sensibility of the proteins to these acid proteinases.

Amino Acids, Dicarboxylic↗
PubMed1980

[Detection of the neurotropic properties of the serum of schizophrenia patients].

A method of testing neurotropic properties of the serum of schizophrenic patients is proposed. This method was tested on 27 schizophrenic patients and based on experimental data. In all cases there was a narrowing of the width of the glomerular zone in the adrenal glands of rats administered the serum of schizophrenic patients intravenously. There was a significant difference in the width of the zone depending upon the stage of the disease and exacerbation, while in experiments, depending upon the presence of antibodies to brain subcommissural organs.

Adrenal Cortex↗
PubMed1979

[Immune complexes in multiple sclerosis and experimental allergic encephalomyelitis].

Immune complexes in the blood serum were determined in patients with disseminated sclerosis and in dogs in the process of experimental allergic encephalomyelitis. In disseminated sclerosis the existence of immune complexes was found in the exacerbation period and their absence in remissions. In animals with clinical signs of experimental allergic encephalomyelitis the immune complexes began to be established in the period of sensitization and attained the maximum in the preparalytic and paralytic period. In animals without clinical signs, the immune complexes were determined later and in insignificant amounts. The role of immune complexes in the pathogenesis of exacerbations in disseminated sclerosis and development of experimental allergic encephalomyelitis as factors involved in the disturbances of permeability in the hematoencephalic barrier is discussed.

Adrenalectomy↗
PubMed1979

[Kinin system components and immune complexes in schizophrenia].

The sera of schizophrenic patients showed existence of immune complexes and an increased activity of kallikrein, as well as relationship between these indices and the phase of the process. Their totality may be recommended for evaluating the activity of the process and efficacy of the treatment.

Antigen-Antibody Complex↗
PubMedDate not supplied

[Arginine esterase, kalnikreine and antitryptic activities in experimental allergic encephalomyelitis in dogs].

In experimental allergic encephalomyelitis in dogs within seven days after immunization with encephalytogenic emulsion and in an acute period of the disease arginine-esterase and kallikreine activities were increased by 68% and 218%, respectively; antitryptic activity was simultaneously decreased in blood serum. If the symptoms of the disease were less distinct and also in animals, which were treated with Freund's stimulator, alterations in activity of the enzymes studied were found to be negligible.

Animals↗
PubMedDate not supplied

[The surface structures and biological properties of Klebsiella strains].

The electron-microscopic method has been used to study the surface structures and biological properties (adhesiveness, antibiotic-resistance, biochemical properties) in 67 strains of Klebsiella isolated from one-year-old children with intestinal infections (56) and from healthy ones (11). It is found that bacterial cells in 58.2% of strains have fimbriae of the 3d type, in 20.9%--of the 1st type. No correlation has been revealed between the type of fimbriae and the studied properties.

Bacterial Adhesion↗
PubMedDate not supplied

[Biochemical and ultrastructural changes in animal brain after intracisternal administration of the cerebrospinal fluid from patients with schizophrenia].

After intracisternal administration of liquor from patients with schizophrenia into rabbits and rats content of catecholamines, gangliosides and cerebrosides was decreased, while acid proteinase was activated in brain tissue. At the same time, ultrastructural impairments occurred in nervous cells. These data suggest that cytotoxic antibrain antibodies are present in liquor of schizophrenic patients.

Animals↗
PubMedDate not supplied

[Ultrastructural characteristics of the biological action of an endotoxin on sensorimotor cortical neurons].

The work is devoted to the ultrastructural investigation of the state of the sensomotor cortex neurons after intravenous and intracisternal administration of endotoxin. The evidences are presented concerning ultrastructural alterations in mitochondria and the presence of compensatory reaction in them after intravenous injection of endotoxin. Besides, coated vesicles and subsurface cisternae whose formation is induced by the endotoxin action have been studied.

Animals↗