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Biomedical subjects

G A Vilkov

Publications and source records attributed to G A Vilkov.

45 records · Page 3Linked to original sources
PubMedDate not supplied

[Kallikrein-kinin system of the synovial fluid in closed injury to the knee joint].

State of the kallikrein-kinin system components (activity of kallikrein and total esterase activity of trypsin-like enzymes) was studied in synovial fluid at the acute period of the knee joint closed injury. The kallikrein activity as well as the esterase activity of trypsin-like enzymes correlated completely with clinical manifestations of the reactive arthritis. These enzymes appear to have a definite importance in development of inflammation in the joint.

Acute Disease↗
PubMedDate not supplied

[Effect of unithiol on the ultrastructure of the myocardium and adrenals in endotoxin shock].

Administration of unithiol to animals with endotoxin shock promotes deposition of catecholamines in chromaffin cells of the adrenals, blocks their secretion to the bloodstream and prevents the development of injuries to the cortical substance of the gland. Administration of unithiol for endotoxemia prevents damage to intracellular organelles of cardiomyocytes. However, insignificant disorders of the contractile apparatus of the cells and histohematic barriers are maintained. The capacity of unithiol to prevent the progress of destructive alterations in the heart and adrenals permits recommending it for use in combined treatment of septic conditions.

Adrenal Glands↗
PubMedDate not supplied

[Cerebral gangliosides in dogs in experimental allergic encephalomyelitis].

Content of gangliosides was decreased in white substance of brain hemispheres and in spinal cord of dogs with typical symptoms of allergic encephalomyelitis. The decrease in content of less polar fractions was compensated by an increase in concentration of more polar gangliosides. After an intracisternal administration of the antibrain antibodies the content of gangliosides was also decreased in brain cortex and white substance of hemispheres. The data obtained suggest that the neurone membranes are impaired under the pathological conditions as well as that the antibrain antibodies are important for development of the structural impairments observed.

Animals↗
PubMedDate not supplied

[Activation of acid proteinase from rat brain in presence of blood serum from patients with multiple sclerosis and schizophrenia in in vitro experiments].

Distinct activation of rat brain acid proteinase was found, if blood serum from patients with some neuropsychical diseases or blood serum from the animals immunized by the patient brain tissue as well as by main protein of myelin were added into the incubation mixture; this demonstrates the labilizing effect of antibrain antibodies on lysosomes. The enzymatic activation might serve as a diagnostic test for estimation of antibrain antibodies in blood serum.

Animals↗