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Biomedical subjects

G Anger

Publications and source records attributed to G Anger.

At least 37 records · Page 2Linked to original sources
PubMed1983

[Results of combined antineoplastic polychemo- and radiotherapy in small cell bronchial cancer and implications for optimizing therapy].

It is reported on 60 patients (48 males and 12 females) who since 1977 have undergone a combined chemotherapy with 5-fluorouracil, vincristine and vinblastine , respectively, methotrexate and cyclophosphamide. After 1--2 initial cycles simultaneously to the chemotherapy a radiotherapy was performed under telecobalt conditions. In the patients with a limited disease 83% full remissions and 17% partial remissions were achieved. In those cases in which an extensive disease was present 19% full remissions and 65% partial remissions could be achieved. A tumour progression was observed in 16%. The mean survival time in complete remissions is 15.5 months and in partial remissions 10.8 months. Three patients are to be estimated as long-term survivors. Thus, the results are not more unfavourable than in other therapy strategies. Despite the progress in the past these results of the treatment cannot satisfy. Better results are possible by the application of cisplatin and etoposide, by which means, however, the danger of the threatening side-effects of the therapy increases. The strategy of treatment favoured nowadays provides an aggressive induction polychemotherapy, which at an interval of 4 weeks is followed by the loco-regional radiotherapy. Following this a chemotherapy is again performed. With regard to them there are no unique conceptions. Polychemotherapy regimes with not cross-resistant cytostatics administered alternatingly give theoretically the prerequisites for more favourable results, which, however, need stil confirmation in clinical oncology. Apart from other questions it is above all necessary to clarify the kind of therapy after full remission.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1983

[Results of polychemotherapy (a VMCP/VCAP program) in multiple myeloma].

62 patients with multiple myeloma were primarily treated with the combination vincristin + melphalan + cyclophosphamide + prednisolone (VMCP). In therapy failures and relapses, respectively, vincristin + cyclophosphamide + adriamycin + prednisolone (VCAP) were administered. Under primary treatment with VMCP in 28 patients (45%) remissions were obtained, in 22 patients (36%) incomplete remissions and 12 patients (19%) were estimated as therapy failures. The secondary application of VCAP increased the total number of the remissions to 32 (52%). Incomplete remissions and therapy failures more frequently appeared in the clinical stage III and in undifferentiated myelomas. The median survival time of the total group was 46 months. With more than 60 months patients with remission showed significantly larger median survival times than those ones with incomplete remission (14.5 months) and therapy failures (6 months), respectively.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1982

[Tumor chemotherapy as an interdisciplinary task].

The chemotherapy in tumours is interpreted as an interdisciplinary task. In this case the therapeutic centres for haematology and oncology which were developed in the GDR following an international trend are of particular importance. Perspective developments are shown.

Antineoplastic Agents↗
PubMed1982

[Leptospiroses with acute renal failure--report on 6 dialyzed patients].

From 1968 to 1981 6 patients with severe leptospiroses were treated: one with leptospirosis icterohaemorrhagiae (Weil's disease), two with leptospirosis copenhageni and three with leptospirosis grippotyphosa. The diagnosis must at first clinically be made from exposition anamnesis and symptoms. In three patients the agglutination lysis reaction had a negative result still between the 10th and 19th day after the beginning of the disease. In all 6 cases a hypercatabolic acute renal failure with azothaemia of high degree was present. The polyuric phase developed 10 to 18 days after the beginning of the disease, the serum creatinine values normalized 20 to 35 days after the beginning of the disease. The parenteral nutrition and the dialysis therapy were particular points in the complex therapy of the patients. 4 patients were haemodialysed - 3 of them after primary peritoneal dialysis - 2 patients were only peritoneally dialysed. On account of the hypercatabolism and the intestinal paralysis the haemodialysis is to be preferred, as a rule, to the peritoneal dialysis. Also in the haemodialysis of patients with leptospirosis modern developments should be taken into consideration: bicarbonate-containing dialytic solution and in haemorrhagic diathesis the heparin-free dialysis. All 6 own patients survived. When connecting these data with other reports from Central and South Europe the lethality of dialysed cases with leptospirosis is about 42% (25 of the 59 patients died). In 4 of 5 of our patients with leptospirosis a clear hyperamylasaemia was present, apparently the expression of the involvement of the pancreas.

Acute Kidney Injury↗
PubMed1982

[Fungal infections in urologic diseases with special reference to mixed bacterial infection].

A report is given on the mycological examination of urine from 146 urological patients. The possible influence of a mixed infection with bacteria on the growth of blastomyces is discussed. Whereas in the organism bacteria and blastomyces can exist well in conjunction, especially gram-negative bacteria in a culture medium can inhibit the growth of blastomyces. The result would be wrongly negative culture results. In our tests mixed infections of candida albicans and/or candida guilliermondii with escherichia coli and/or enterococci were found. Therefore it is recommended to add a suitable antibacterial antibiotic to the test material and to carry out a simultaneous bacterial urine culture. Where there is a urological primary disease and the urine has to be sent a long way we recommend Gentamycin, in a dosage of 200 micrograms/ml urine, for its good sensitivity.

Aged↗
PubMed1980

[Differential diagnosis of introduced malaria].

It is reported on three cases of malaria tertiana and on one case of malaria quartana in combination with a peritoneal tuberculosis, emphasizing the differential-diagnostic problems.

Adolescent↗
PubMed1980

[Bacterial diseases in internal medicine caused by infection].

A survey is given on infection-conditioned bacterial diseases in internal medicine. Important for practice is the classification of the infectious diseases in such with high and slight contagiousness as well as in infection-conditioned diseases with special affection of organs, the symptoms of which coin the further course. Furthermore is referred to the differentiation of specific infectious diseases with clear reference to a definite causative organism and of unspecific infectious diseases which in the majority represent themselves as polyetiologic syndromes with uniform clinical pictures. More discussed are the infectious hospitalism, the salmonellial enteritis, the yersinioses, typhoid fever, paratyphoid fever, bacterial dysentery, scarlet fever, diphtheria, meningitis, brucelloses, leptospiroses, listerioses, pneumonias, bronchitis, obstructive diseases of the respiratory tract as well as pyelonephritis and bacterial carditis.

Anti-Bacterial Agents↗
PubMed1980

[The so-called partial synchronization in the treatment of malignant lymphomas. A clinical study].

In a randomized study the effectiveness of a modified MOPP scheme (CVPP scheme) and a so-called partial synchronisation treatment (vincristine or vinblastine respectively and cyclophosphamide) was compared in 72 patients predominantly pretreated with Hodgkin lymphomas and non-Hodgkin lymphomas. From 49 patients affected with lymphogranulomatosis of stage IIIB and IV, 24 were treated according to CVPP scheme; in 10 of them a complete remission was achieved and in 4 of them a partial remission. 25 patients were treated in the control group with synchronization therapy. In 13 of them a complete remission and in 12 of them a partial remission was achieved. With CVPP therapy the mean remission time amounted to 14.4 months and with synchronization therapy 9.2 months. There was no significant statistical difference. From 23 patients with advanced non-Hodgkin lymphomas of a high malignancy 11 received a therapy with CVPP scheme; 2 of them came into a complete remission and 3 of them into a partial one. 12 patients received a synchronization therapy; 7 of them came into a partial remission. With CVPP therapy the mean remission time amounted to 14.4 months, with partial synchronization therapy--10.8 months. Even in non-Hodgkin lymphomas there was no significant difference between the forms of therapy used. Even a comparison of the two survival times of both forms of treatment does not reveal any significance. Thus, both procedures of treatment seem to be comparable in their therapeutic efficaciousness, even if the number of complete remissions during the treatment with CVPP scheme was greater in our investigations. The assumed lower toxicity of synchronization therapy could not be confirmed by our study. In addition to the controversial synchronization effect, the good efficaciousness of treatment according to the so-called synchronization therapy may be due to sensibilizing phenomena and recruitment phenomena.

Bleomycin↗
PubMed1980

[Objective determination of prostate size with ultrasound].

The rectal digital examination of the prostate is, despite the high diagnostic value, for a large part subjective in its evidence. By means of the ultrasound examination the size of the prostate may be objectified, which otherwise is difficult to be described, and thus may be used as a firm and reproducible relation size in the diagnosis and control of the course of disease of the prostate which are accompanied by an increase of the organ.

Adult↗
PubMed1980

[Changes in the system of kidney pelvis and calices in bladder neck adenoma].

The development of a renal lesion following an adenoma of the vesical neck is one of the most important complications of this disease. For the determination of the frequency of changes of the renal calyces in the adenoma of the vesical neck the findings of 253 patients of the years 1976 and 1977, in whom for the first time such an excrescence was established were evaluated. 135 excretion urogrammes showed changes of the renal pelvis and the renal calyces. The main findings were a narrowing of the renal calyces with spindle-shaped necks of the calyces. The calyces themselves were deformed only in one part of the patients. Urinary stasis and cirrhoses of the kidney were not found. As cause of the narrowed renal calyces in correlation with the clinical and laboratory-clinical findings the chronic pyelonephritis, the latent dehydration of the patient and disturbances of the motility of the urodynamics are discussed. As conclusion of these results the opinion is uttered that all male persons from 45 years, who have clinically healthy kidneys and in whom for any reasons an excretion urography has been performed, and in which evaluation narrowed renal calyces were found, by all means must undergo the examination by an urologist for the exclusion of a disease at the vesical neck.

Adenoma↗