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Biomedical subjects

G Axelsson

Publications and source records attributed to G Axelsson.

65 records · Page 4Linked to original sources

Exposure to anaesthetic gases and spontaneous abortion: response bias in a postal questionnaire study.

A postal questionnaire study on anaesthetic gas exposure and miscarriage rate was performed among women who worked or had previously worked in a Swedish hospital. Results were evaluated in relation to age, smoking habits, work site at the first trimester of pregnancy and clinical accuracy of the reported data. An important part of the study was the collection of information on pregnancies among non-respondents. A higher, although non-significant, miscarriage rate was reported among women who had worked in areas with high exposure during the first trimester compared to unexposed women. A selection was found among the non-respondents with respect to both working site during pregnancy and outcome of pregnancy. All women suffering a miscarriage while working at sites with exposure to anaesthetic gases reported their work site and miscarriage, while one third of all miscarriages occurring to women who were not exposed during pregnancy were not reported in the questionnaire.

Abortion, Spontaneous↗

Torus mandibularis among Icelanders.

Nine hundred and seventy-six Icelandic schoolchildren (489 male and 487 female) were surveyed for occurrence of torus mandibularis. No sexual dimorphism was observed but there was a statistically significant difference between areas. A highly significant positive association between age and frequency of occurrence and size was also observed. Single tori were more prevalent than multiple ones and also appeared earlier. Symmetrical occurrence predominated, but when unilateral, tori were more often found on the right side. Secular changes in the incidence of torus mandibularis among Icelanders suggest the strong influence of environmental factors.

Adolescent↗

Pregnancy abnormalities among personnel at a virological laboratory.

Observations on an increased spontaneous abortion rate initiated a study among personnel working at a laboratory for diagnostic virology. Personnel at a bacteriological laboratory and at another virological laboratory served as controls. Seventy-seven female employees at the laboratory for virology were interviewed, as well as 91 at the bacteriology laboratory and 45 women at another virological laboratory. A significantly increased perinatal death rate was found among the virology personnel, with no apparent clustering over the time period studied. A higher serum titer against common viruses was found among employees actively working with patient sera. A model experiment demonstrated the risk for aerosolization of serum samples during processing. No evidence of a relationship between chemical work environment factors and the increased perinatal death rate was found. It is concluded that the factor in the working environment most closely related to the increased perinatal death rate was exposure to viral aerosols.

Abortion, Spontaneous↗

The deflecting wrinkle on the teeth of Icelanders and the mongoloid dental complex.

Three local populations from Northeast Iceland are surveyed for the occurrence of the deflecting wrinkle of the metaconid on second deciduous and first permanent lower molars. The trait occurs more frequently on dm2 than on M1, and no sexual dimorphism is found, as expected. However, the frequencies are clearly within those predicted by the Mongoloid dental complex for Mongoloid populations. It is therefore suggested that the inclusion of the deflecting wrinkle in the Mongoloid dental complex be re-evaluated, and the racial diagnostic value of the trait taken with reservation.

Adolescent↗

Prothrombin determination by means of a chromogenic peptide substrate.

A two stage method to determine prothrombin with the chromogenic peptide substrate benzoyl-phe-val-arg-p-nitroanilide has been worked out. Citrated plasma (10 mul) was diluted in 600 mul tris buffer, pH 8.2, ionic strength 0.18 and activated with 250 mul of a commercial rabbit brain-lung thromboplastin. After 325 s incubation at 37 degrees C 200 mul of a 1 mM solution of the chromogenic substrate was added and the increase in absorbance was recorded in a LKB-Beckman 8600 enzyme analyzer. A reading time of 1 minute (including a delay of 20 s) was used which permitted 55 analyses per hour to be carried out. An approximate linear relationship was found between delta A/min and dilutions of normal plasma in prothrombin deficient plasma. The method is insensitive to variations of factors V, VII and X. Less than 10% or normal plasma was needed to "normalize" plasmas deficient in factor V or VII or X. A group of 99 dicoumarol treated patients and 23 normal subjects has been investigated using the present method and compared with a factor II-VII-X determination method. A correlation coefficient of 0.95 was found.

Dicumarol↗

Relationship between work environment and anamnestic health status. Use of predictors, indicators and indices for the evaluation of medical and environmental factors.

Experience with computerized medical record systems in handling medical data in hospital and health screening environments has led to the development of a new approach to the evaluation of medical data. Predictors and indicators quantify the "information value" of medical data and can, theoretically, do so for all types of data. This paper describes the methodology and presents the results obtained when the technique was applied to the anamnestic data of the medical history and environmental data about the conditions in the work environment. Over 4,000 individuals who underwent multiphasic health screening were used as a data base for this study. From these 4,000 persons 3,164 were used for the calculation of anamnestic predictors and indicators and 1,013 for the environmental predictors and indicators. Anamnestic environmental indices were calculated upon 77 test individuals so as to correlate the association and dependence of the two indices.

Environmental Exposure↗