Suggestions for standardized clinical photography in plastic surgery.
Explore the source record for details and available documents.
Female↗
Biomedical subjects
G B Jemec
Publications and source records attributed to G B Jemec.
Topical treatment of skin ulcers in prolidase deficiency.
Prolidase deficiency is a hereditary enzyme deficiency characterized dermatologically by chronic recurrent ulcers and scarring due to increased skin fragility. It has been speculated that the enzyme deficiency causes a relative deficiency of proline in the wounds of these patients and negatively affects clinical healing. Two ulcers in a 17-year-old girl with established prolidase deficiency were treated for 12 weeks with ointments containing amino acids in an open study comparing the effects of 5% proline and a combination of 5% proline plus 5% glycine. Both ointments caused significant reduction of the ulcer size (p < 0.02), but the 5% proline-5% glycine mixture caused a more rapid reduction (0.01 < p < 0.02). The results confirm previous findings in this rare inborn error of metabolism.
Administration, Topical↗
The inherent capacitance of moisturising creams: A source of false positive results?
The capacitance is a frequently used measurement of skin hydration in vivo, therefore any potential for false capacitance results is of importance. This in vitro study is to investigate the capacities of moisturizing creams to cause false positive results. Adding different volumes of demineralised water and saline on dry clean plastic-backed tissue paper and measuring the capacitance values, the standard relation curve of capacitance value and volume of water was established. Four moisturizing creams, petrolatum, a protective cream and a gel were then applied to the same kind of tissue paper in constant volumes, and were measured for weights and capacitance values over a 1-hour period allowing the gradual evaporation of water and volatile elements. A positive linear relationship was found between volume of water and capacitance value. All the creams had inherent capacitance that correlated with their water content. The inherent capacitance of creams decreased over time and ultimately reached comparable low values. The decrease in capacitance correlated significantly with weight reduction, except for petrolatum, which showed negligible inherent capacitance and weight reduction. The rates of decrease in capacitance value versus cream weight were significantly different for different creams. The results assured that capacitance value correlates to water content, and the inherent capacitance of creams may contribute to false positive skin capacitance in vivo if measured before water and other volatile elements of creams evaporate from the skin surface. In addition, the inherent capacitance and its durability may be relevant characteristics for further comparative studies of moisturizers and their clinical efficacy.
False Positive Reactions↗
Moisturisers for psoriatic skin--do gross morphological differences matter?
Studies suggest that moisturisers have a beneficial effect on psoriasis, and their use in preventive or adjuvant dermatological therapy is therefore of considerable clinical interest, although no classification of these products exists to guide their use. We have previously suggested a classification based on the ability of moisturisers to induce mechanical changes in normal skin. In psoriasis patients obvious objective differences exist between plaques and clinically uninvolved skin. This study was undertaken to investigate if these differences influence the mechanical response to moisturisers. Skin mechanics distension and hysteresis, Dermaflex as well as capacitance Corneometer 812 CM and moisturiser absorption were measured on psoriasis plaques and adjacent clinically uninvolved skin of 17 psoriasis patients. Three commonly available moisturisers, a barrier cream and a gel were tested. Baseline distensibility and capacitance were significantly lower for plaques (p < 0.0001), and all moisturisers increased distensibility in both lesions and adjacent skin. Hysteresis was generally affected to a greater degree by Locobase. The gel caused greater increases in hysteresis outside plaques. Capacitance was significantly increased in plaques, except for areas treated with Locobase, while only Decubal appeared to cause significant increases in uninvolved skin. Locobase showed better absorption in plaques than in control areas. No objective differences were found in the effects of moisturisers between psoriatic plaques and adjacent clinically uninvolved skin, suggesting that the significant clinical differences between lesional and paralesional skin do not influence the efficacy of moisturisers.
Adult↗