[Harmful effects on the fetus and newborn infant of drugs administered to the mother in the pre-, intra- and post-natal period].
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Biomedical subjects
Publications and source records attributed to G Barboni.
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Blood glucose, plasma insulin and plasma glucagon were determined during an arginine test at 0, 30 and 60 min in 1 to 7 and 30 day infants. The results were compared with those obtained in the 2-10-year-old children. Basal levels of blood glucose increased from the 1st to the 30th day; by the 30th day they were comparable with those observed in the 2-10-year-old children. Basal levels of plasma insulin were higher in 1 day infants, lower in 7 day infants and similar to those of the 2-10-year-old children in the 30 day infants. Basal values of plasma glucagon were higher in 1 day infants than in the 2-10-year-old children; the lowest levels were found in 7 day infants. After arginine, blood glucose increased in the 2-10-year-old children, the variations were negligible in the 1 to 7 and 30 day infants. Plasma insulin increased in 2-10-year-old children, there was a slight increase in 1 and 30 day infants and a negligible one in the 7 day infants. Plasma glucagon increased in the 2-10-year old children, and was similar in 1 day infants; the increase was reduced in 30 day infants and virtually absent in 7 day infants. These results suggest that there is a transitory alpha cell insensitivity to arginine during the first week of life.
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Synthesis and biological activities of cyclosaligenyl-tiazofurin monophosphate (CycloSal-TRMP), a new tiazofurin pronucleotide, are reported. CycloSal-TRMP proved to be active in vitro against human myelogenous leukemia K562 cell line and as A1 adenosine receptor agonist.
This work suggests a quality control method for thermoluminescent dosimetry. For each set of dosemeters, read-out has been made at increasing values of dose, on the base of predetermined conditions in different read-out techniques and from different operators. The statistical analysis of each possible group of T.L.D. permitted us to draw the error-response curves and the relative precision profiles and to select the best evaluation techniques and the best operator on the base of precision, sensitivity and useful range.
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Two cases of Poland syndrome, diagnosed during the neonatal period, are reported. The children exhibited the following malformations: absence of the costosternal head of the pectoralis major, brachysyndactyly, hypoplasia of the upper limb. There were also other associated anomalies such as: Sprengel deformity in one case, hypoplasia of the lower limb and absence of a toe on the same site, in the other case. The authors point out the possibility of associating other multiple abnormalities and they examine the various pathogenic hypothesis presented in the literature.
The authors present a critical revision of the literature concerning the pathogenic hypotheses and the opinions, during the centuries, about the origin of the deformities caused by amniotic bands. Here they describe two cases of severe deformities caused by amniotic bands which can be classified in types I and V according to Onnipoff and Hall. In the first case the newborn died immediately after the birth: the other one lives in good health after multiple surgical operations. In accordance with the anatomical reports that were found using very specific techniques and methods, the authors are inclined to accept Torpin's hypothesis, which affirms that the initial moment of the series of events which causes the formation of the amniotic bands is the breakage of the amniotic sac.