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Biomedical subjects

G Bode

Publications and source records attributed to G Bode.

At least 55 records · Page 3Linked to original sources
PubMed1981

Bulbar palsy with Rosenthal fiber formation in the medulla of a 15-year-old girl. Localized form of Alexander's disease?

A 15-year-old girl died of a long-standing bulbar palsy that had caused difficult swallowing since early infancy. She was severely malnourished and retarded in growth. Morphologically, the clinical symptoms corresponded to a circumscribed lesion in the enlarged medulla (mega-medulla) that consisted of proliferation of astrocytes, incomplete demyelination, perivascular infiltrates and abundant formation of Rosenthal fibers. Rosenthal fibers were also present in the subpial medullary region where inflammation and astrocytic proliferation were largely absent. This patient's disorder appears to be a localized form of alexander's disease because macrencephaly, Rosenthal fiber formation and leukodystrophy of the cerebral hemispheres and cerebellum were absent. The morphological spectrum of Alexander's disease may now comprise diffuse and localized forms both of adulthood and children.

Adolescent↗
PubMed1980

Progressive dementia with "diffuse Lewy-type inclusions' in cerebral cortex. A case report.

A 69-year-old male suffering from progressive dementia died 3 years after the beginning of his disease. The neuropathology of this case revealed the coexistence of senile changes, typical for Alzheimer's disease, and the characteristics of Parkinson's disease, namely, numerous senile plaques and neurofibrillary tangles in the cerebrum and neuronal loss with depigmentation in the substantia nigra and locus caeruleus. Lewy-type inclusions were distributed not only in the pigmented brain stem nuclei, but also diffusely in the CNS. The close nosological relationship between paralysis agitans and Alzheimer's disease is discussed.

Aged↗
PubMed1980

[Investigations on the morphology and biochemistry of wound healing after injury of the liver (author's transl)].

The early phase of wound repair after liver incisions was investigated by histological, enzyme-histochemical, and biochemical methods in guinea pigs. There are considerable differences in cellular and histochemical reactions in comparison to incisions of the skin: 1. The rapid leukocytic reaction showed little change during the observation interval (48 h). In short survival times epithelial cells show signs of hypoxidosis and loss of glycogen at the edge of an incision. Proliferation of organ-specific and mesenchymal cells was observed after more than 24 h. 2. Alterations of the investigated enzymes in the traumatic area are important diagnostic parameters in the early stages of wound healing. 3. In the early 12 h after injury distinct increase of histamine was observed, while serotonin was noticed to decrease. 4. Therefore, the determination of wound age in the early wound reactions after injuries of the liver should include enzymehistochemical methods.

Acid Phosphatase↗
PubMed1979

[The influence of hypnotics on the development of morphological and biochemical wound reaction (author's transl)].

The influence of hypnotics (barbital and carbromal) on the development of the early wound reactions in mechanically injured skin of guinea pigs was investigated: 1) The cellular reactions in incised wounds were retarded after moderate intoxication by hypnotics (300 mg/kg barbital; 3 g/kg carbromal). The histomorphological changes in wounds were inhibited by carbromal twice as much as by barbital. The hitherto published investigations had not shown any retardation of the early cellular inflammation by weakening influences such as loss of blood or alcohol without symptoms of shock (Berg et al., 1977) or local disturbances by acids and bases (Kampmann et al., 1978). 2). A moderate delay of the activity of structure bound enzymes was found in barbital intoxication, a stronger restriction under the influence of carbromal. 3) After barbital intoxication significant elevation of histamine or serotonin in wounds was not seen. Under the influence of carbromal there was also no increase of histamine but an increase of serotonin. Thus, although the cellular reactions seem to be the most reliable indicator among the methods for the determinations of wound age under devitalizing influences, their value is reduced in cases of intoxications by hypnotics needing treatment. Possible pathophysiological connections of the alterations of morphological and biochemical wound reaction with shock are discussed.

Animals↗
PubMed1978

[The influence of acids and bases on the development of morphological and biochemical wound reactions (author's transl)].

1) The influence of acids and bases on the development of the early wound reactions in the intact and the mechanically injured skin of guinea pigs was investigated. The cellular and the enzymohistochemical reactions showed to be different: the tissue leucocytosis after mechanical trauma is less restrained by chemical effects than the reactive increase of enzymic activity in the border of wounds, which proved to be affected by acids more than by bases. Changes in activity of structure bound enzymes could not be demonstrated in the skin after mere action of acids and bases, but only after mechanical trauma. The cellular reaction is in the border of the base necrosis more compact, in case of the acid necrosis broader and more diffuse. Characteristic changes in the nucleus were preferentially found after basic reaction. 2) In the mechanically unhurt skin a significant excess of histamine was found after the action of acids, while the liberation of serotonin was distinctly decreased. After incision and addition of acid the histamine level was decreased and the serotonin concentration significantly increased. After exposition of guinea pig skin to chemicals, the concentrations of the so-called tissue hormones showed a contrary course. 3) After postmortal incision and following cauterization a distinct increase of histamine was found in the wound area. Generally the excess of free histamine in comparison to the unhurt skin is considered to be a vital reaction. But because degranulation of mast cells and liberation of histamine can also be caused by chemical influence in the postmortal period, a critical interpretation in cases of skin exposition to acids or bases is necessary.

Animals↗
PubMed1977

[The influence of loss of blood and alcohol intoxication on early vital wound reactions (author's transl)].

The influence of loss of blood and alcohol intoxication on wound reactions in the first 12 hours after incisions into the skin of the back of guinea pigs was examined. As the most important result we found differences in the cellular and zymohistochemical reactions: while begin and progression of the dermal leucocytosis were not influenced, the parallel running activation of different structure bound enzymes was significantly delayed and decreased. Considering the first result and the haematogenous origin of the leucocytes there is reason to believe that in the hierarchy of the biological control circuit-at least in guinea pigs-the local reflex hyperaemia of the wound area certainly is primary to the dermal vasoconstriction during collapse. The animals with haemorrhagic shock showed a retardation in the liberation of histamine and serotonin. This decrease of the local mediators of the stromae dissociation is considered the reason of the impaired initial enzyme activities in the mesenchymal tissue.

Alcoholic Intoxication↗