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Biomedical subjects

G Boog

Publications and source records attributed to G Boog.

At least 73 records · Page 4Linked to original sources
PubMed1990

Prenatal diagnosis of del(15)(q11q13).

A case of del(15)(q11q13) was detected in amniotic fluid cell cultures and confirmed by cordocentesis in a 27-year-old woman with a low maternal serum alpha-fetoprotein level. The fetus was shown to have a short femoral length on ultrasonography. This structural chromosome abnormality associated with the prenatal ultrasonographic findings and the morphological characteristics visualized after termination of pregnancy strongly suggest Prader-Willi syndrome.

Adult↗
PubMed1990

[The contribution of umbilical and cerebral Doppler velocimetry in the diagnosis and monitoring of intrauterine growth retardation].

The authors studied the arterial circulation in the umbilicus and brain in 140 cases of intrauterine delayed growth using a pulsed Döppler system. Results were expressed in terms of a circulatory index. The Pourcelot resistance index is defined as S-D/S, where S represents the maximum systolic rate and D the maximum telediastolic rate and is used both for the umbilicus (Rp) and the brain (Rc). In order to evaluate the diagnostic and prognostic performance of the Döppler method, the values of the various indices were analyzed as a function of the foetal cardiac rhythm during labour, the method of delivery and the state of the infant at birth. The authors concluded that umbilical blood flow measurement was of moderate diagnostic values, while the unitary placental resistance index was of undeniable prognostic value (76 p. cent of foetal distress at birth, perinatal mortality of 30.30 p. cent). A pathological brain resistance index preceded the occurrence of abnormalities in foetal cardiac rhythm by 24 hours to 5 days in 64.28 p. cent of the cases and was always associated with foetal distress at birth. The authors considered it was important to take the respective short-term changes in values of the various circulatory indices into consideration rather than the isolated values themselves. The brain-placenta ratio (BPR = Rc/Rp) may perhaps constitute the best indication in the early screening of foetal hypoxia.

Adult↗
PubMed1990

[Benign cutaneous lesions observed within the 1st 48 hours of life in 874 infants born at a maternity ward of a university hospital. Apropos of 148 cases].

A six months' follow-up study was carried out in the nursery of the University Hospital of Brest where neonates were systematically evaluated for dermatological abnormalities. 148 neonates had birthmarks which were erythema toxicum (ET) in 103 cases, vascular lesions in 19, pigmented in 8, and miscellaneous lesions in 18. These results were compared with those previously reported (1, 3, 6, 7, 9, 10, 13, 14). They confirmed the high frequency of ET in the second day of life and the low frequency of pigmented lesions at birth in Caucasians (less than 2 p. 100), as compared with their frequency in coloured people and Asians (25-40 p. 100) (10). The low proportion of salmon patches in this study may be explained by an inappropriate collection of data compared with previous reports (20-40 p. 100) (7, 10). A possible relation between the presence of ET and the later development of atopic dermatitis is discussed.

Dermatitis, Atopic↗
PubMed1989

[Congenital atrioventricular block and maternal lupus erythematosus. Histologic discovery of tumor of the atrioventricular node].

A case of congenital atrioventricular block in a newborn whose mother presented with systemic lupus erythematosus (SLE) is reported. Despite intensive care the child died a few hours after birth. Serial sections of the heart could be examined. Histology provided information on the appearance and distribution of the lesions. In particular, the sinus node was small for the child's age, and its supplying artery was found to have a hyperplastic media with adventitial sclerosis; the interatrial and interventricular septa showed subendocardial fibrosis invading the adjacent myocardium. Owing to the scarcity of systematic histopathological examinations, such lesions have seldom been described. In addition, a tumour of the atrioventricular node, known as mesothelioma or hemolymphangioma, was discovered. This case is exceptional in that histopathological findings similar to those described in SLE, though rarely as numerous, were associated with a very rare tumour never hitherto described in such a young patient. The relationship between the two categories of lesions is discussed.

Adult↗
PubMed1989

[Fetal supraventricular tachycardias and their treatment. Apropos of 23 cases].

The management of fetal heterotopic tachycardias is reviewed from a cooperative study involving 23 cases treated by French Pediatric Cardiology Centers at Angers, Brest, Nantes, Rennes and Tours. There were 17 cases of supraventricular tachycardia (SVT), 5 of flutter and 1 of atrial tachycardia. Seventeen mothers were given an antiarrythmic treatment. They all received Digoxin by mouth, with either Propranolol in 2 cases, Sotalol and Verapamil in one case each. In 5 cases 2 or more other drugs were associated. There was a good in utero response in 12 cases. Among the 23 patients, 5 died, all with hydrops fetalis at the time of diagnosis of SVT. Finally 2 newborns were successfully treated at the time of delivery by a direct puncture of the umbilical cord.

Anti-Arrhythmia Agents↗
PubMed1988

[Maternal determination of fetal movements. A sure and simple method of monitoring the pregnancy].

Counting of fetal movements (FM) by the mother-to-be was first recommended by Sadovsky in 1973. Objective studies have demonstrated that 82 to 87 p. cent of FM visible on cardio-topographic tracings or in ultrasound recordings are indeed felt by the pregnant woman. Currently, two protocols are employed: Cardiff's method (counting of 10 FM beginning at 9 a.m.) and Sadovsky's method (counting of FM for one hour at three different times of day). From a practical standpoint, a sudden increase in the incidence of vigorous and forceful movements followed by their stoppage corresponds to compression of the umbilical cord. A decrease in FM may represent a fetal malformation or intrauterine fetal asphyxia. The positive predictive value of counting of FM by the patient in the detection of fetal distress is 64 to 78 p. cent, with a decrease in fetal activity preceding changes in fetal cardiac rhythm by 12 to 96 hours. This simple, sure and readily applicable method ensures continuous monitoring of fetal behavior, while clinical or electronic monitoring is necessarily discontinuous.

Female↗
PubMed1988

[Neonatal hemolytic anemia after intra-amniotic injection of methylene blue].

The authors report two cases of neonatal hemolytic anemia without methemoglobinemia secondary to intraamniotic injection of 10 mg of methylene blue. Evolution was favourable without exchange transfusion. This emphasizes the importance of searching for a toxic origin in case of neonatal hemolytic anemia without apparent cause.

Adolescent↗
PubMed1988

[Prenatal diagnosis of mucoviscidosis. Contribution of DNA analysis of trophoblast biopsies].

The gene for cystic fibrosis has been localised on the long arm of chromosome 7. Genetic engineering techniques now make it possible to inform educated families that it is possible to make an early antenatal diagnosis on chorionic villus sampling at the tenth week of pregnancy. We report our experience on ten antenatal diagnosis that were made. Furthermore, we were able to study 48 families with a live child who had the disease, and were able to change the probability of another child being born with the gene. This approach makes it possible for us to change the risk for a couple of giving birth to an affected child. It is also possible to extend the indications for trophoblast analysis to parallel cases where the risk is less than 1 in 4.

Chorionic Villi Sampling↗
PubMed1988

[Molecular biology and mucoviscidosis. Brest experience in 1987].

The gene for cystic fibrosis is located on the long arm of chromosome 7 at 7q31. The close linkage between the disease locus and several DNA markers allowed a study of the DNA restriction polymorphism pattern in 30 Breton families. The frequency of the haplotypes indicated by the probes pJ 3.11, met H and met D was established reaching a 66.6% informativity for the families studies. The complete informativity of a family allows for detection of heterozygous brothers and sisters, uncles and aunts and for antenatal screening on trophoblast biopsies in case of further pregnancies.

Child↗
PubMed1983

[25-hydroxyvitamin D plasma levels in adults, neonates and their mothers].

25-hydroxyvitamin D (25 OH vit D) plasma levels were measured according to the method of Preece et al. in 2 groups of subjects. Group 1 consisted of 10 adult controls in whom 25 OH vit D levels were measured 11 times at 1 month intervals. Group 2 consisted of 93 mother-child pairs including 71 neonates with normal plasma calcium levels (group 2a) and 22 with hypocalcemia (group 2b). In mothers, 25 OH vit D levels (group 2a: 12 ng/ml +/- 6.4 SD, n = 71; group 2b: 9.5 ng/ml +/- 3.5 SD, n = 22) were lower than in controls (25.1 ng/ml +/- 7.9 SD). In neonates, 25 OH vit D levels were correlated with those of their mothers; however there was no significant difference in neonates with or without hypocalcemia (group 2a: means = 11.9 ng/ml +/- 6.1 SD, n = 71; group 2b: means = 10 ng/ml +/- 4.1 SD, n = 22). 25 OH vit D levels in adults of group 1 were significantly correlated with exposure to sunlight, while no significant correlation was found in the mothers-children pairs of group 2. These results confirm the relationship of 25 OH vit D plasma levels of neonates with their mothers' but do not support the concept of a relation between low plasma levels in mother and the occurrence of hypocalcemia in neonates.

Adolescent↗
PubMed1980

[Perinatal mortality in twin pregnancy. 576 case histories (author's transl)].

The authors report on the result of a retrospective survey which they carried out in 8 Hospital Centres in the West of France between 1975 and 1978 and these were concerned with 576 twin pregnancies. This study confirms that the fetal prognosis in twins is precarious. The perinatal mortality is high and is made up at the same time of a stillbirth rate of 5 per cent and a neo-natal mortality rate of 6 per cent, which is mainly due to prematurity (49.6 per cent) and to intra-uterine growth retardation in 19.3 per cent. Studying these results and the figures given in the literature, the authors analyse the ways in which this mortality can be reduced: early diagnosis, rest, screening for fetal low growth and a sensible broadening of the indications for Caesarean section. This broadening appears to them to merit consideration especially in three circumstances: intra-uterine growth retardation, premature labour between the 31 and 33 week after the last period and transverse presentation of the second twin that cannot be turned.

Female↗