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Biomedical subjects

G Boog

Publications and source records attributed to G Boog.

At least 91 records · Page 5Linked to original sources
PubMed1977

A long term evaluation of infants who received a beta-mimetic drug while in utero.

The administration of beta-mimetic drugs to pregnant women poses the problem of possible long-term repercussions in the children born to these mothers. 42 children from women who had been treated with 60-80 mg a day of ritodrine hydrochloride (Pre-par), during a period varying from 3 to 93 days, were closely matched with infants from untreated mothers. Each child, (aged from one to 3 years), was fully investigated on the basis of: a detailed questionnaire to the mother; careful clinical examination; assessment of psychomotor development; the Denver test; electrocardiography and urine analysis. There was no statistically significant difference between the two groups for any of the variables of development that were studied. One child had left ventricular hypertrophy, which was probably incidental. It is concluded that administration of ritodrine hydrochloride to pregnant women induces no harmful long-term effects in their offspring.

Body Height↗
PubMed1977

[Study of fetal respiration by ultrasound. Correlation with gestational age and diagnosis of fetal distress].

The authors, following the work of Boddy and Robinson, studied the value of recording fetal breathing activity in the antenatal diagnosis of fetal distress. Fetal respiratory movements are detected with unidimensional echography, thanks to an electronic grille which is able to isolate a thoracic echo which is then reproduced on a rapid recorder after amplification. In normal pregnancies there is a highly significant correlation between fetal respiratory activity and the length of amenorrhoea. In a series of twelve cases with fetal distress that were recorded during labour and were defined after delivery by an Apgar score of less than or equal to 6 and an umbilical arterial pH less than or equal to 7.17, prenatal recordings showed a pathological reduction in fetal breathing movement in 9 cases. In this series only 5 cardiotocograms were shown to be abnormal.

Female↗
PubMed1976

[Diagnosis of fetal distress during labor with the aid of the Hammacher cardio-tocographic score and fetal pH determination].

The authors study the value of the Hammacher tocographic scoring system in the diagnosis of fetal distress in labour. This score gives equal value to three components of the fetal heart rate: the base line, transient variations (dips) and fluctuations (oscillations). There is a statistically very significant (p less than 0.001) relationship between the cardio-tocographic score and the fetal pH as has been found in 106 labours with a coefficient of correlation of 0.67. The score can only be carried out usefully when a "beat to beat" to heart rate is registered and when this is not influenced by the administration of drugs to the mother. The score has been demonstrated to be particularly useful in the diagnosis of fetal distress when the membranes are still intact.

Female↗
PubMed1975

Beta-mimetic drugs and possible prevention of respiratory distress syndrome.

The prophylactic value of beta-mimetic drugs in preventing respiratory distress syndrome (RDS) is investigated by comparing 29 preterm infants of ritodrine treated mothers with 34 preterm infants of a control group. Five cases of RDS (17 per cent) occurred among the infants of treated mothers as compared with 12 cases (35 per cent) in the control group (p = 0-09). The difference is, however, statistically significant for the group of infants weighing less than 2300 grams (p = 0-01) which includes all infants affected with RDS.

Adrenergic beta-Agonists↗
PubMedDate not supplied

Persisting spongy myocardium. A case indicating the difficulty of antenatal diagnosis.

Persisting spongy myocardium (also known as noncompaction of the ventricular myocardium) is a rare and special form of cardiomyopathy. The few cases reported in the literature were detected postnatally and involved a high rate of cardiovascular complications. This anomaly of endomyocardial morphogenesis, which occurs during the embryonic phase at the stage of cardiac partitioning, is characterised by an excessive number of prominent trabeculae and by intertrabecular recesses within the myocardial wall. Antenatal detection is difficult in the absence of an associated malformation, which is the general situation. We report a case of antenatal cardiomyopathy which led to therapeutic abortion. The diagnosis of persisting spongy myocardium was made during fetopathologic examination.

Abortion, Therapeutic↗
PubMedDate not supplied

Contribution of tridimensional sonography and magnetic resonance imaging to prenatal diagnosis of Apert syndrome at mid-trimester.

A diagnosis of Apert syndrome, suspected at 24 weeks' gestation after conventional sonography showing turribrachycephaly and syndactyly of hands and feet, was confirmed at 26 weeks' gestation by tridimensional sonography and magnetic resonance imaging. This is only the second prenatal diagnosis reported at mid-trimester, excluding cases published from affected mothers or in connection with a context of recurrence. Additional findings have been collected from tridimensional sonography (mid-facial hypoplasia, downslanting palpebral fissures) and from magnetic resonance imaging (verticalization of the clivus and flattened angle of the cranial base).

Acrocephalosyndactylia↗