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Biomedical subjects

G Borg

Publications and source records attributed to G Borg.

At least 19 recordsLinked to original sources
PubMed1999

The perceived intensity of caffeine aftertaste: tasters versus nontasters.

The length and intensity of the aftertaste of caffeine was measured in groups of tasters and nontasters in order to determine if any differential information could be provided by aftertaste perception. Results indicate that a period of 4 min is sufficient to see differences between tasters and nontasters, and that nontasters' aftertaste of the saturated solution is equal in intensity with tasters perception immediately after stimulus presentation, but then after approximately 1 min fade faster. Nontaster ratings for the weaker solution were lower throughout the entire time period.

Caffeine↗
PubMed1995

Patients with rheumatoid arthritis benefit from early 2nd line therapy: 5 year followup of a prospective double blind placebo controlled study.

OBJECTIVE: To compare 2 treatment strategies in a prospective 5 year study of patients with rheumatoid arthritis (RA): early treatment with slow acting antirheumatic drugs (SAARD) versus a "wait and see" attitude. METHODS: One hundred thirty-seven patients with RA of < 2 years' duration entered a double blind placebo controlled study: patients in the "early" (E) group were treated with auranofin within one year of diagnosis of RA, and SAARD treatment in the initially placebo treated group was delayed 8 months compared with the former group. [The results after 2 years clearly favored early treatment (Borg G, Allander E, Lund B, et al: J Rheumatol 1988; 15:1747-54)]. RESULTS: After a total observation period of 5 years in 75 representative patients, continued improvement in the E group was demonstrated, and differences between the 2 groups were maintained with regard to clinical variables, outcome measures, and radiographic evaluation. CONCLUSION: The results indicate the existence of a therapeutic window in RA within the first 2 years of the disease.

Adult↗
PubMed1994

Adjuvant growth hormone treatment during in vitro fertilization: a randomized, placebo-controlled study.

OBJECTIVES: To explore the effect of recombinant, human GH on follicular development and oocyte retrieval after gonadotropin stimulation with the addition of GH or placebo to a standard IVF treatment regimen. Further, to investigate whether GH is a more effective adjuvant if the standard treatment regimen is preceded by GH injections. DESIGN: A randomized, double-blind, parallel, placebo-controlled study. SETTING: The IVF unit at university hospital. PATIENTS: Forty normally ovulating women, age 25 to 38 years, with infertility because of tubal factors and being classified as "poor responders" with at least two previously performed and failed IVF attempts. INTERVENTIONS: Human, recombinant GH (Genotropin, Kabi Pharmacia, Uppsala, Sweden) or placebo (0.1 IU/kg body weight per day) was given SC as pretreatment during down regulation with GnRH and during stimulation with hMG according to the randomized protocol. MAIN OUTCOME MEASURES: Number of oocytes retrieved after stimulation, total amount of gonadotropin used, time required for stimulation, number of follicles developing, rate of fertilization, and cleavage in vitro. Further, the quality of embryos, development of the endometrium, rate of clinical pregnancy, and serum and follicular fluid (FF) concentrations of insulin-like growth factor I (IGF-I), insulin-like growth factor binding protein-1 (IGFBP-1), and IGFBP-3 were estimated. RESULTS: The number of oocytes retrieved did not differ significantly between the groups, nor did the amount of hMG required for stimulation. The fertilization rate increased in patients who had received GH. Growth hormone caused a significant increase in serum and FF levels of IGF-I. An increase in serum IGFBP-3 could also be recorded in patients who had received GH. CONCLUSION: Although certain beneficial effects were noted in GH-treated patients, the overall results did not support GH as a clinically useful adjuvant treatment.

Adjuvants, Pharmaceutic↗
PubMed1993

Perception of heavy work operations by tank truck drivers.

Seven male tank truck drivers were followed for about 3 h during ordinary work. They rated the perception of heavy work operations on Borg's CR-10 scale. The heart rates were monitored every minute. The hose was pulled out an average of 22.3 m and the corresponding mean rating was 3.2, a little above 'Moderate' on the CR-10 scale. The heart rate averaged 137 beats/min at the end of this operation. When transforming the physiological parameter heart rate to a subjective strain intensity, surprisingly high agreement was obtained between the results from the field study and the predicted ratings. By transforming ordinally scaled data from another study to a scale with ratio properties, the results could be compared with this study. Good agreement was found between the variables.

Journal Article↗
PubMed1992

Comparison between the Visual Analogue Scale (VAS) and the Category Ratio Scale (CR-10) for the evaluation of leg exertion.

Perceptual ratings given on the Visual Analogue Scale (VAS) and the Category Ratio Scale (CR-10) were compared in 24 healthy male volunteers (18-39 years) subjected to an exercise test using a bicycle ergometer. Ratings of leg exertion were made by means of the CR-10, the VAS and, as a complementary measure, the method of free magnitude estimation (ME). Blood lactate levels (BL) and heart rates (HR) were used as correlates to sensory perception. The correlation between the CR-10 ratings and BL at 180 W were .59 (p less than .01), and between VAS ratings and BL .45 (p less than .05). The corresponding correlations with HR were .64 (p less than 0.01) and .58 (p less than 0.01), respectively. No significant correlation was found for ME. It was concluded that both the CR-10 and the VAS scales were found to be useful for the psychophysical estimation of perceptual intensities. The CR-10 scale appeared to be slightly more efficient than the VAS and both these methods much better than ME. The advantage of the CR-10 scale might be due to a greater ability to discriminate at high intensity levels.

Adolescent↗
PubMed1991

[Catamenial pneumothorax].

Pulmonary endometriosis has been described as occurring in two forms: --bronchopulmonary with haemoptysis at the periods, --pleuropulmonary with pneumothorax at the periods. In 30-40% of cases it is associated with pelvic endometriosis. The pathways along which it can be disseminated are: --transdiaphragmatic peritoneal migration, --or metastatic migration through the veins and lymphatics. The treatment at present consists of hormone therapy together with surgery.

Adult↗
PubMed1991

Auranofin treatment in early rheumatoid arthritis may postpone early retirement. Results from a 2-year double blind trial.

The effect of early vs delayed initiation of slow acting antirheumatic drug (SAARD) therapy on the ability to maintain regular work, was evaluated in 83 patients with early rheumatoid arthritis (RA) in a placebo controlled, double blind 24-month study. The estimated probability to maintain working ability was higher in the early treatment group, especially during the second study year. Predicting factors were age, type of work, degree of disability and number of swollen joints. Despite the difficulties in interpreting the results due to the complexity of the underlying socioeconomical and labor market situation, the study supports early treatment in RA with regard to the maintenance of normal life.

Arthritis, Rheumatoid↗
PubMed1991

Psychophysical power functions of exercise limiting symptoms in coronary heart disease.

Thirty consecutive male patients with angiographically determined multivessel disease and ten healthy volunteers were subjected to a symptom limited exercise test with stepwise increments of 10 W every minute. Leg exertion, breathlessness, and chest pain were rated according to a category-ratio scale with 10 degrees and psychophysical power functions computed. Depending on whether chest pain was the limiting symptom, patients were subdivided into groups A (N = 20) and B (N = 10). Exercise capacity did not differ between groups A and B. Both groups terminated the exercise test at lower work loads and lower symptom intensities than the healthy volunteers. Psychophysical power functions were similar for leg exertion in the three groups while the growth of breathlessness was lower in group B. In group A the intensity of chest pain increased more rapidly than leg exertion or breathlessness. In conclusion, those patients with coronary heart disease interrupt the exercise test at lower ratings of leg exertion and breathlessness than healthy volunteers. The psychophysical power functions do not grow more rapidly for these sensory modalities in patients than in healthy volunteers.

Anxiety↗
PubMed1990

Effect of alcohol on perceived exertion in relation to heart rate and blood lactate.

The purpose of the study was to determine whether the perception of exertion is affected by alcohol during physical performance and whether altered self-rating of exertion is the result of an altered perception per se or of an altered physical capacity to perform work. Ten healthy men participated. Each subject was his own control and received an alcohol dose corresponding to 1 g.kg-1 body mass in 40% solution in the experimental session. The exercise test was performed on a cycle ergometer with an initial intensity of 50 W which was increased stepwise by 50 W at 4-min intervals up to near-maximal. The rating of perceived exertion (RPE) did not differ between alcohol and control sessions. Alcohol induced a significant increase in heart rate during exercise at 50 W (delta x = 8 beats.min-1) and at 100 W (delta x = 10 beats.min-1), while the change at higher intensities was insignificant. The systolic blood pressure and the blood lactate concentration were not significantly changed by alcohol. It is concluded that a moderate dose of alcohol does not alter RPE during physical exercise either per se or secondarily to an altered physical capacity to perform work.

Adult↗
PubMed1990

Disease-modifying anti-rheumatic drug therapy. An expensive therapy despite inexpensive drugs.

In a study of the costs for drug therapy, 81 patients with rheumatoid arthritis taking parenteral gold, penicillamine or chloroquine were included. The patients were assessed for costs, directly and indirectly caused by the therapy, during a 12-week period. The three therapy groups were comparable in terms of number of patients, sex, age and duration of disease. There were substantial differences in costs for therapy between the three disease-modifying anti-rheumatic drugs. Treatment with parenteral gold gave the highest cost, 2.2 times that of chloroquine and 1.4 times the cost of penicillamine. The cost for the antirheumatic drug constituted a minor part of the total cost (4.4-15.4%). The need for patient visits for treatment and safety controls was a major factor in the overall cost.

Adult↗
PubMed1990

Psychophysical scaling with applications in physical work and the perception of exertion.

In studies on work it is important to assess various subjective symptoms, complaints, and annoyances. To measure such symptoms, psychophysical ratio scales may be used, as along with simpler category rating scales. In this paper some of the basic concepts and methods of psychophysics have been described. In the field of heavy physical work and the perception of effort and exertion, one of the most popular methods is the rating of perceived exertion. This scale has been presented together with a new category ratio scale, commonly referred to as the CR-10 scale. Some situations in which it is important to obtain measurements of perceived exertion have also been described in the paper.

Humans↗
PubMed1989

Auranofin (SK&F) in early rheumatoid arthritis: results from a 24-month double-blind, placebo-controlled study. Effect on clinical and biochemical assessments.

In a 2-year, randomized, double-blind Nordic multicentre trial, auranofin was compared with placebo in early (disease duration less than or equal to 2 years), active rheumatoid arthritis (RA). Efficacy and safety were analysed in 67 patients receiving auranofin and 65 receiving placebo. Life table analysis demonstrated a significantly higher withdrawal rate due to insufficient therapeutic effect in the placebo group, whereas more patients dropped out due to side effects in the auranofin group. More auranofin than placebo patients (35 vs. 24) completed the 2 years. Clinical and inflammatory activity improved in both groups, but consistently more so in the auranofin group, in spite of the greater consumption of local steroids and NSAIDs in the placebo group. The most frequent side effects leading to withdrawal in the auranofin group were cutaneous and gastrointestinal reactions. The study demonstrated that most patients exhibit improvement in clinical signs and symptoms and about half of all patients with early RA continue to take auranofin for at least 2 years.

Anti-Inflammatory Agents, Non-Steroidal↗
PubMed1988

Auranofin improves outcome in early rheumatoid arthritis. Results from a 2-year, double blind placebo controlled study.

The effect of early initiation of auranofin (AF) therapy on outcome measures was studied in a controlled 24-month double blind trial in 138 patients with early rheumatoid arthritis (RA) using an intent to treat approach. Patients were randomized to AF or placebo but in case of insufficient effect or intolerable adverse events, they switched to open disease modifying antirheumatic drug therapy. Patients who started AF fared significantly better in improved joint swelling. Stanford Health Assessment Questionnaire index, Keitel functional test, and mental depression, and furthermore, radiologic progression was significantly retarded. Our results support a disease modifying beneficial effect of AF in early active RA.se

Anti-Inflammatory Agents, Non-Steroidal↗
PubMed1988

Dose-effect relationship of adenosine provoked angina pectoris-like pain--a study of the psychophysical power function.

In an analysis of the psychophysical power function of chest pain induced by adenosine, this agent was repeatedly given in increasing doses into a peripheral vein to six healthy volunteers (five men) aged 23-44 years. On the first day the maximum tolerable dose was determined. On the second day seven doses of adenosine (20, 30, 40, 50, 60, 80 and 100% of the maximum dose) were given single blind in randomized order followed by another seven doses in reversed order. The heart rate was calculated from electrocardiographic recordings. Chest pain was continuously rated according to the CR-10 scale. Before the adenosine test, the perception of sourness was tested similarly with six concentrations of citric acid (1-100 mM). The psychophysical power functions were similar for the perception of sourness provoked by citric acid and chest pain provoked by adenosine, with exponents of 0.69 +/- 0.21 and 0.60 +/- 0.32, respectively. The two modalities showed the same high goodness of fit to the power function (rxy being 0.965 +/- 0.030 and 0.967 +/- 0.033, respectively). For adenosine the group mean relation was R = 1.66(S-2.36)0.6, rxy = 0.999. No signs of tolerance were observed for the chest pain provoked by adenosine. In conclusion, chest pain provoked by adenosine follows a psychophysical power function as with other sensory modalities.

Adenosine↗
PubMed1987

Perceived exertion related to heart rate and blood lactate during arm and leg exercise.

To compare some psychophysiological responses to arm exercise with those to leg exercise, an experiment was carried out on electronically braked bicycle ergometers, one being adapted for arm exercise. Eight healthy males took part in the experiment with stepwise increases in exercise intensity every 4 min: 40-70-100-150-200 W in cycling and 20-35-50-70-100 W in arm cranking. Towards the end of each 4 min period, ratings of perceived exertion were obtained on the RPE scale and on a new category ratio (CR) scale:heart rate (HR) and blood lactate accumulation (BL) were also measured. The responses obtained were about twice as high or more for arm cranking than for cycling. The biggest difference was found for BL and the smallest for HR and RPE. The incremental functions were similar in both activities, with approximately linear increases in HR and RPE and positively accelerating functions for CR (exponents about 1.9) and BL (exponents 2.5 and 3.3 respectively). When perceived exertion (according to the CR scale) was set as the dependent variable and a simple combination of HR and BL was used as the independent variable, a linear relationship was obtained for both kinds of exercise, as has previously been found in cycling, running, and walking. The results thus give support for the following generalization: For exercise of a steady state type with increasing loads the incremental curve for perceived exertion can be predicted from a simple combination of HR and BL.

Adult↗
PubMed1987

A psychophysical study of work-related stress using observer ratings.

In two experimental series a panel of observers rated the perceived exertion of a worker performing different tasks. The first experiment involved the lifting of boxes of different weights. The second experiment comprised combined static and dynamic work of the assembly-line type during a full working day. The results show that the observers were able to discriminate between the different loads in all stress situations. Since the loads ranged from low to maximal stress, all were able to make assessments over the full range. Furthermore, the relationship between observer ratings and self-ratings approximated a logarithmic function with the observers tending to overestimate the low stresses while there was closer agreement in the rating of high stresses.

Humans↗
PubMed1987

[Tubal choriocarcinoma].

The authors report a case of tubal choriocarcinoma discovered by chance during an ectopic pregnancy. The literature was reviewed on this subject. The treatment vary according to the authors, but, it would seem that chemotherapy has clearly modified the prognosis. But, we must realize that, with such a rare disease, diagnosis and treatment are sometimes difficult to obtain.

Adult↗