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Biomedical subjects

G Brucker

Publications and source records attributed to G Brucker.

At least 37 records · Page 2Linked to original sources
PubMed1985

[Alcohol consumption in developing countries. Review of available data for 3 African countries].

The increasing alcohol consumption throughout the world appears to constitute an enduring public health problem. In developing countries, the consequences of such consumption should be considered as questions of both classical alcohol-linked pathology and of food balance. Available data for 3 countries in Africa (Burkina Faso, Congo, Cameroons) show an important growth in the industrial production of alcoholic beverages (mostly beer) over the last 20 years, while variation in traditional home production remains unknown. However, the lack of data on consumption does not permit a good appreciation of this problem.

Alcohol Drinking↗
PubMed1984

[Problems raised by the treatment of Kaposi's sarcoma in subjects with AIDS].

Kaposi's Syndrome (K. S.) was defined as a virus induced immunogenic tumour responding to interferon. It can be used as a guideline for therapeutical trials in A. I. D. S. K. S. mortality is 13%. K. S. + O. I. (opportunistic infections) mortality reaches 70% and O. I. mortality is approximately 50%. Therefore treating O. I. is a must but it is not mentioned in the paper. Attempts made to modify immunodepression, usual K. S. treatments, experimental treatments based upon similar pathogenicity (like systemic lupus erythematosus, Hansen's disease, preneoplasia dyskeratosis) were unsuccessful. Trials with alpha recombinant interferon realised at the Sloan Kettering Memorial for Cancer in New York are summarized for 74 patients and are in preliminary interpretation. Our study is based upon 13 cases studied for 14 to 4 months and comes up to the same conclusions using 18 to 36 million units/day for 6 months (6 cases) and 3 to 4 months (7 cases). For 6 full treatments the results are: 2 K. S. were cleaned up after 8 and 3 months follow up, 4 K. S. with O. I.: 3 remissions and then relapses and 1 stabilization, for 7 current treatments: 2 had to be discontinued because of bad tolerance, 1 stabilization and 4 remissions. For all treatments a decrease and a lesser gravity of O. I. can be noted during treatment. Besides flu-like syndromes, main clinical side effects, are: asthenia, general condition impairment, 2 fits were observed for which I.N.F. cannot be clearly incriminated. Daily treatment compelling and surveillance are real drawbacks. Different types of better used interferon will probably yield interesting results (40% regression or improvement).

Acquired Immunodeficiency Syndrome↗
PubMed1982

[Cutaneous lesions in human African trypanosomiasis].

We report the case histories of 12 patients infected by Trypanosoma gambiense seen between 1967 and 1979. The course of the disease follows two stages, with the lymphatic and hematologic stage preceding invasion of the central nervous system. The following cutaneous lesions were recorded: 5 patients had trypanomas or chancres which are inflammatory nodules on uncovered areas; 5 patients showed trypanosomal skin rashes with erythematous, infiltrated, transient and recurring trypanids; 5 patients had soft transient edema, affecting mainly the face; 3 patients experienced pruritus, which was usually mild and limited to small areas; 3 patients had cutaneous lesions induced by melarsoprol. Thus dermatologic features are common in human African trypanosomiasis; they were found in 75% of the patients in our department.

Adult↗
PubMed1982

[Treatment of urinary and intestinal bilharziosis with praziquantel. Apropos of 182 cases].

182 patients representing 188 cases of schistosomiasis (including 152 S. haematobium, 34 S. mansoni, and 2 S. intercalatum cases) were treated with praziquantel using 40 mg/kg in a single intake. Biological check-up did not reveal any abnormality that could have been related to the treatment. Clinical side-effects appeared in 25% cases and were essentially gastrointestinal symptoms, headaches, dizziness. Efficiency was assessed by direct parasitological examinations of the feces or urine that were performed after treatment. It reached 91% for S. haematobium and 95% for S. mansoni schistosomiasis.

Adolescent↗
PubMed1981

Imported malaria in a hospital in Paris.

The number of cases of imported malaria diagnosed by the Parasitology Laboratory of the Pitié-Salpêtrière Hospital Group in Paris has shown a significant increase in recent years. From 1970 to 1979, 443 cases were diagnosed and the annual number recorded during this period rose from seven to 93 cases. This is causing anxiety since Plasmodium falciparum is the principal species observed, affecting two out of three patients. The principal epidemiological characters of malaria imported into France, the diagnostic difficulties and the therapeutic schedules are shown in a study of 192 case histories of patients observed by the authors.

Adolescent↗
PubMed1980

[Histoplasmosis: clinical, biological, and therapeutic aspects in ten cases (author's transl)].

The authors present 10 cases of histoplasmosis, 3 due to H. capsulatum, and 7 to H. duboisii. The presenting signs were stomatological or laryngeal with H. capsulatum, and ganglionic, cutaneous, or skeletal with H. duboisii. Diagnosis was confirmed by the discovery of histoplasms in the lesions: 7 times the examination of a needle biopsy sample was positive; in 8 cases out of 10, culture on Sabouraud's medium was positive; in 3 cases out of 4 the inoculated hamster showed the presence of a histoplasmosis. Histological examination of lesions biopsies demonstrated histoplasms in the 9 cases studied. The intradermal reaction to histogical examination of lesion biopsies demonstrated histoplasms in the 9 cases studied. The intradermal reaction to histoplasmin, positive in only 1 out of 7 cases, and serological tests which showed precipitating antibodies in only 4 cases out of 10, are of very little diagnostic value. All patients were treated with amphotericin B, sometimes associated with clotrimazole (3 cases), miconazole (1 case), and rifampicin (2 cases). Two relapses occurred, one, after too soon an interruption of treatment relapsed two months later, and the other followed 18 months after a total dose of 4,200 mg of amphotericin. Surgical treatment of active subcutaneous ganglionic and bony foci may be necessary, and was employed in three cases, with a favourable result in a case of severe disseminated histoplasmosis.

Adolescent↗
PubMedDate not supplied

[Initial therapeutic trials of an antibilharzial agent, 35 972 R.P. in man].

35,972 R. P. is a new schistosomicidal drug deriving from a thione dithiole pyrazinyl basic structure. It has been assessed with 125 patients suffering from an urinary tract schistosomiasis (69 cases) or from an intestinal schistosomiasis (56 cases). Five regimens have been followed. The last one was 1.50 g/day over 3 days and it included 75 patients. The clinical tolerance was satisfactory although vomiting was reported in 16 % cases and headaches were noted in 21 % cases. The efficiency was remarkable as 97 % patients were cured. New studies are been performed on a one day treatment basis.

Humans↗
PubMedDate not supplied

[Clinical and diagnostic features in seven cases of sacro-iliac tuberculosis. Contribution of bone scintigraphy (author's transl)].

Sacro-iliac tuberculosis was detected in seven African immigrants following attacks of sacrolumbar pain with fever, over a period of five years. Two of the patients had a previous history of tuberculosis, and in six out of the seven cases the osteo-articular affection was part of a multifocal tuberculous disease. The value of bone scintigraphy is discussed. Surgical treatment was performed together with medical therapy in three cases.

Adult↗
PubMedDate not supplied

[Malaria caused by multi-resistant Plasmodium falciparum contracted in Tanzania].

In a severe case of malaria, the chemosensitivity of a Plasmodium falciparum strain from a traveller to Tanzania who underwent chemoprophylaxis treatment with chloroquine (600 mg weekly) was evaluated in vitro. In the 28 hours maturation assay and a 72 hours proliferation assay, the strain proved to be highly resistant to chloroquine and to have a reduced sensibility to the sulfadoxin - pyrimethamin association.

Adult↗