[Urbanism and public health in the tropics].
Explore the source record for details and available documents.
Africa↗
Biomedical subjects
G Brucker
Publications and source records attributed to G Brucker.
[Curative treatment of malaria Plasmodium falciparum, P. vivax and P. ovale malaria with mefloquine].
Mefloquine (WR 142-490, RO 21.5998), and antimalarial 4-quinoleine-methanol, active on multiresistant strains of P. falciparum is a resourceful product because of its pharmacocinetics and the possibility it opens of a single day curative therapy. Its mean half-live is 15 days, with important individual variations from 8 to 23 days as well as racial one within North-American, Asiatic or African patients. A 1,25 to 1,50 g dose divided in 2 or 3 intakes during 16 hours has proved to be effective in 34 P. falciparum cases. Lower doses, near 1 g seem sufficient for P. vivax (6 cases) and P. ovale fits (4 cases). Clinical and biological acceptance are good, according to this limited study. The use of mefloquine might nowadays be reserved for geographical areas where resistance to P. falciparum is significantly high. Its diffusion in Africa, south of the Sahara, though conceivable, might be discarded for the time beeing.
Adolescent↗
[Drug resistance to malaria. Apropos of 17 cases in 2 years].
17 cases of resistant P. falciparum malaria are reported. They were observed in different populations: on one hand 9 Cambodian children refugees in France, on the other hand 8 French adults consulting after travels in South America or in South-East Asia. Different resistance levels to amino-4-quinolines and to a combination of sulfadoxine and pyrimethamine were found: they were more often from the RI type but sometimes from the RIII type also. 6 patients were treated with Mefloquine. Its activity was constant and rapid.
Adult↗