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Biomedical subjects

G Caputo

Publications and source records attributed to G Caputo.

At least 55 records · Page 3Linked to original sources
PubMed1986

T lymphocyte subsets and platelet-associated IgG in idiopathic thrombocytopenic purpura: effect of splenectomy.

The modifications of cell-mediated immunity in idiopathic thrombocytopenic purpura (ITP) were investigated using the technique of Moretta et al. [J. exp. Med. 151: 969-974, 1980] to study T lymphocyte subsets in 35 ITP subjects at various clinical stages. In all these patients, platelet-associated IgG (PAIgG) were measured by a complement lysis inhibition technique. Untreated ITP patients did not show significant modifications of T lymphocyte subsets. Patients with thrombocytopenia not responsive to corticoids or splenectomy and increased PAIgG levels showed significant reduction of Fc-gamma-bearing T lymphocytes (T-gamma). Patients 'cured' by splenectomy (12 out of 17) showed a normal PAIgG level, a marked increase of T-gamma cells and a reduction of T-mu cells; patients 'not cured' by splenectomy showed an increased PAIgG level and a reduction of T-gamma cells. An increase of PAIgG levels and a reduction of T-gamma cells were found in 2 splenectomized patients after relapse. An association between chronic nonresponsive ITP and decrease of T-gamma cells was established.

Adolescent↗
PubMed1986

MRI of reperfused myocardial infarct in dogs.

The current study evaluated the capability of magnetic resonance imaging (MRI) to detect acutely injured myocardium in the first 5 hr after a 1-hr period of occlusion followed by reperfusion of the coronary artery and to determine if magnetic relaxation times could be used to differentiate injured from normal myocardium. Fourteen dogs underwent left anterior descending coronary arterial occlusion for 1 hr, followed by reperfusion. Electrocardiographic gated MRI was performed before and during coronary artery occlusion and immediately after reperfusion, and serially up to 5 hr postreperfusion. In all dogs with postmortem evidence of myocardial infarction (n = 7), regional increase of signal intensity was observed in the anterior wall of the left ventricle as early as 30 min after reestablishing blood flow to the jeopardized myocardium. The area of increased signal intensity in the myocardium conformed to the site of myocardial infarction found at autopsy. The signal intensities of the jeopardized myocardium were significantly (p less than 0.01) greater than those of normal myocardium at 30 to 300 min postreperfusion. The T2 (spin-spin) relaxation time was significantly (p less than 0.05-p less than 0.01) prolonged in the region of the reperfused myocardial infarct at 30 min (59.6 +/- 13.1 msec) and remained prolonged up to 300 min (62.6 +/- 12 msec) postreperfusion compared with the T2 of normal myocardium (40.6 +/- 5.2 msec). Of the remaining seven dogs, four developed fatal arrhythmias during the reperfusion procedure and three dogs had no evidence of myocardial infarction at pathologic examination. Signal intensities and T2 relaxation times in these three dogs did not change during the experiment. Thus, acutely infarcted and reperfused myocardium can be detected by in vivo gated MRI, using the spin-echo technique, as early as 30 min after reperfusion. The jeopardized myocardium is characterized by a prolonged T2 relaxation time and, therefore, best visualized on T2-weighted images.

Animals↗
PubMed1985

Anoxic cardiopulmonary arrest in a pediatric animal model: clinical and laboratory correlates of duration.

We studied the response to anoxia in young dogs in order to provide some clinical and laboratory guidelines with which to gauge duration of respiratory and cardiorespiratory arrest in children. Immediately following the onset of anoxia, the animals developed hypertension. After a mean period of 279.5 seconds (range, 224 to 325 sec), they became asystolic. Following an observation period of five minutes after the onset of asystole, pH declined to a mean of 7.01 and PO2 declined to 7.1 torr, while PCO2 rose to 92.1 torr. We concluded that asystole occurs after a relatively brief period of anoxia during a time interval when the brain retains the potential for full recovery. While no single factor clearly indicates a very prolonged arrest, a pH below 6.9 which does not rise with the institution of adequate ventilation suggests anoxia of greater than five minutes' duration.

Animals↗
PubMed1984

[Indications and role of ultrasonography, transhepatic percutaneous cholangiography and endoscopic retrograde cholangiography in obstructive pathology of the distal choledochus].

The authors refer the results obtained with ultrasonography (US), percutaneous transhepatic cholangiography (PTC) and endoscopic retrograde cholangiography (ERC) in the diagnosis of obstructive jaundice. One-hundred and forty-four patients have been investigated, on the basis of biological, clinical and ultrasonographic findings, by PTC or ERC. The high percentage rate observed in PTC-approached patients suggests that the combination of US-PTC would appear to provide an important role in diagnosing obstructive jaundice.

Adult↗
PubMed1983

[Post-embryonic genesis of bursal follicles in the duck].

The structural and histological characteristics of the limiting layer between the cortex and medulla of the bursa of Fabricius in the duck are described in relation to different functional moments of the organ. On E.M. study the limiting layer, in duck having 30 days of age, is constituted of reticular-epithelial cells palisades in shape with many cytoplasmics extension. Lymphatic migration occur in interstitial spaces.

Animals↗
PubMed1983

Usefulness of carcinoembryonic antigen measurement in gastric juice of patients with gastric disorders.

Due to conflicting reports on the role of CEA measurement in the gastric juice of patients with gastric malignancy, we have assessed gastric CEA levels in a variety of both nonmalignant and malignant lesions of the stomach. The average gastric CEA levels were higher in patients with gastric ulcer and gastric cancer than in healthy subjects and those with duodenal ulcer. In addition, the frequencies of abnormally high values were significantly (P less than 0.001) higher in gastric ulcer or gastric cancer than in healthy or duodenal ulcer groups, whereas there was no difference between gastric ulcer and gastric cancer groups. The evaluation of gastric CEA levels in relation to gastric inflammatory changes leads us to suggest a close relationship between gastric CEA values and the degree of gastric inflammation. Gastric lavage cytology did not provide a sensitive tool for detection of gastric disorders. This study suggests little value for gastric CEA determination in gastric cancer detection. However, we believe the association of rising gastric CEA levels with various types of gastritis justifies measuring gastric CEA to recognize "precancerous" mucosal changes of the stomach.

Carcinoembryonic Antigen↗
PubMed1983

Surgical sphincterotomy in the early management of non-malignant obstructive jaundice. Indications and results.

Biliary obstruction by non-malignant lesions can be treated either by biliary-enteric anastomosis or by sphincterotomy or sphincteroplasty. In the present report, 153 jaundiced patients operated on by sphincterotomy, were retrospectively examined. Proper indications for surgical sphincterotomy have been considered as follows: stones in the common bile duct (49.7%), biliary stones with secondary stenosis of Oddi (26.8%), impacted ampullary stones (17.6%), primary stenosis of Oddi (3.9%), stenosis of Oddi by perivaterian chronic pancreatitis (2.0%). Preoperative early diagnosis was recognized by US, ERCP, PTC, CT. The overall operative mortality was 2.6% and determined by acute renal failure in 2.0% and acute pancreatitis in 0.6%. Postoperative complications occurred in 4.6% and consisted in acute pancreatitis in 3.3% and bleeding from sphincterotomy in 1.3%. One hundred and twenty-three patients (82.5%) were followed up by questionnaire and by both X-ray studies and ultrasonography. Good results were observed in 80.5%, fair results in 17.1% and poor results in 2.4%. The presents study suggests further indications for surgical sphincterotomy in the treatment of benign biliary obstruction. The effectiveness of this procedure in the early management of non-malignant jaundice is also stressed.

Adult↗