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Biomedical subjects

G Castaldi

Publications and source records attributed to G Castaldi.

At least 37 records · Page 2Linked to original sources
PubMed1983

[Microcytological characteristics of reticulocytes in heterozygous beta-thalassemia].

Mean reticulocyte volume (MRV) and reticulocyte/nonreticulated erythrocyte (R/E) area ratio were determined by a planimetric method in normals and in heterozygous beta-thalassaemia subjects. The MRV in beta-thalassaemia group was significantly less, whereas no difference in the R/E area ratio was observed. These data suggest that in both groups the extent of splenic surface remodeling of the red cells should overlap, whereas the small reticulocyte size of beta-thalassaemia is determined by some alteration of bone marrow function. We suggest that a small MRV in beta-thalassaemia trait could also account for ineffective erythropoiesis, a major bone marrow feature of heterozygous beta-thalassaemia.

Adult↗
PubMed1983

[Migration of hepatic macrophages after cyclophosphamide or whole body irradiation].

The liver macrophages behaviour after cyclophosphamide or total-body irradiation (1000 rads - 60Co) has been studied in the mouse previously injected with colloidal carbon. In these conditions an early increase of carbon-laden macrophages in the central zone of the liver lobules has been observed. Carbon-containing mononuclear cells were also observed in the lumina of the hepatic collecting system. Possible implications of these findings are discussed; a migration of macrophages from the liver to elsewhere is suggested.

Animals↗
PubMed1983

Folic acid deficiency in beta-thalassaemia heterozygotes.

Plasma and red cell folate mean contents have been found to be significantly lower in 41 symptom-free beta-thalassaemia heterozygotes than in 21 controls. Such decreases must be considered as effects of an increased folate utilization caused by the enhanced total, both effective and ineffective, erythropoiesis. Since no close correlation has been found between packed cell volume and plasma or red blood cell folate levels, it seems that in 'healthy' beta-thalassaemia subjects, the degree of anaemia is not influenced by folate body reserves. However, the frequent finding of reduced red cell folate contents suggests that further folate imbalance might lead to clinically significant degrees of folate deficiency.

Adolescent↗
PubMed1982

[Effect of antiblastic polychemotherapy (CMF) on the number of circulating monocytes in patients with breast cancer].

The behaviour of the number of circulating monocytes has been studied in 34 patients suffering from breast cancer and subjected to antiblastic polychemotherapy in accordance with the CMF pattern. In 25 patients the absolute number of monocytes fell after treatment, while in 9 it rose. The percentage of monocytopenic patients rose from 29% to 50% of the total series. The pathogenetic mechanisms of this behaviour are discussed and it is emphasized that antiblastic treatment with cytostatic drugs can be included among the causes of monocytopenia.

Adult↗
PubMed1982

Why inclusion bodies do assume different locations in thalassaemic erythrocytes.

The reported scanning (SEM), transmission (TS), and freeze-etching (FE) electron microscopic studies have agreed in confirming that in thalassaemic erythrocytes, previously incubated with brilliant cresyl blue (BCB), the unpaired alpha chains precipitate in the central portions of the cell whereas excess beta chains locate in the submembranous regions. This is due to the fact that beta chains, possessing two thiols instead of only one (as in alpha chains), are more liable to bind to similar groups contained in the inner red cell leaflet. Less soluble alpha chains tend to form inter-chain bridges and thus precipitate centrally. SEM observations have given evidence that on the surface of the affected red cells denaturated alpha chains give rise to large and shallow invaginations whereas denatured beta chains lead to diffuse wrinkled appearance. The causes of the different SEM aspects have been suggested.

Adolescent↗
PubMed1978

[Phagocytic lymphocyte-like elements (PLLE) and irradiation in vitro].

The peripheral blood of rats contains lymphocyte-like phagocytes after intracardial injection of India ink. In vitro irradiation of whole blood (1000 r - 60Co), causes marked reduction in whole lymphocytes but does not modify the number and morphological integrity of the phagocytes, which can therefore be held to be comparatively radioresistant: as such, they could belong either to the mononucleate phagocyte system or to the lymphatic system (T4 lymphocytes). Since T-lymphocytes are not capable of phagocytosis, the former hypothesis would appear the most probable.

Animals↗
PubMed1977

Tolbutamide-induced hemolytic anemia.

A 67-year-old female diabetic is presented who developed a Coombs'-positive hemolytic anemia after a year of treatment with tolbutamide. An IgG antibody was identified in the patient's serum that caused the agglutination of both the patient's red blood cells and tolbutamide-coated erythrocytes in the absence of complement. Such a reaction did not occur with the patient's erythrocytes when not exposed to tolbutamide. Agglutination of the patient's serum also occurred with erythrocytes treated with other sulfonylureas (chlorpropamide, glibenclamide, carbutamide) but not with phenacetin.

Aged↗