Biomedical subjects
G Castaldi
Publications and source records attributed to G Castaldi.
[Zollinger-Ellison syndrome. Review of a case 15 years after diagnosis].
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[Cryofibrinogenemia, hemophilic syndrome caused by circulating anticoagulants and autohemagglutinins in systemic lupus erythematosus].
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[The biology of lymphocytes. II].
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[Thymic lymphocytolysis and involution caused by cytostatic drugs. (Experimental research)].
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Erythroblastic islands in the bone marrow of rheumatoid arthritis with anaemia.
An increase of erythroblastic islands with recognizable central macrophages was observed in bone marrow of six rheumatoid arthritis (RA) patients suffering from anaemia. Since erythroblastic islands are more prominent in anaemic conditions associated with ineffective erythropoiesis, it is possible that this morphological finding might be an expression of the increased ineffective erythropoiesis observed in RA patients with anaemia.
[The heterozygote beta-thalassemic patient with regard to radiological hazards].
Since anaemia of varying degree is a quite common finding in heterozygous beta-thalassaemia, a research was done to see if beta-thalassaemia heterozygotes occupationally exposed to long-term continuous external radiation should be more susceptible to haematopoietic damage than non thalassaemic subjects. We examined peripheral haematological findings of 20 beta-thalassaemia heterozygotes previously exposed to a mean of 10.7 mSv, compared with 22 non thalassaemic subjects exposed to 6 mSv, and with 50 not exposed beta-thalassaemia heterozygotes. The obtained results suggest that whole-body external irradiation--with the mean doses reported--does not cause noteworthy changes in beta-thalassaemia heterozygotes.
Clinical aspects of beta-thalassaemia minor.
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[Osteoporosis and the thalassemia "trait"].
The authors evaluated the prevalence of the thalassemia trait in a general population affected with femoral neck fractures. Our research was aimed at assessing whether hemoglobinopathy might affect osteoporosis, which is responsible for femoral fractures. Two hundred and thirty-eight patients admitted to St. Anna Hospital, Ferrara, for proximal femoral fractures, were retrospectively studied. The patients were 68 males and 170 females, aged 58 to 83 years (mean age: 70.4 years). The thalassemia trait was seen in 11.76% of cases, versus in 7-8% of the general population. The high prevalence of heterozygous beta-thalassemic subjects probably means that the beta-thalassemia condition is a further "variable" which is responsible for the more frequent occurrence of fractures of the proximal femur and is certainly related to an osteopenic condition much more severe than usual.