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Biomedical subjects

G Cocco

Publications and source records attributed to G Cocco.

At least 109 records · Page 6Linked to original sources
PubMed1977

[Kinetocardiographic surveys in coronary heart disease patients during infusion of isoproterenol and dopamine. A contribution to the diagnosis of coronary insufficiency (author's transl)].

80 patients affected by coronary heart disease, with or without infarction, were studied by kinetocardiographic technique before and after infusion of isoproterenol (ISP) (40 patients) or dopamine (DOP) (40 patients). 40 healthy subjects served as controls (20 for ISP and 20 for DOP). Whereas the infusion of ISP or DOP caused no abnormalities in the healthy subjects, pathological changes of the kinetocardiogram (KCG) were often induced in patients with coronary heart disease. In particular, these changes demonstrated the appearance of paradoxical outward systolic movements, reduction or disappearance of the volume effect during the ejection phase, an increase of atrial waves expressed in per cent of the total amplitude of the KCG. The abnormalities observed during the intravenous infusion of ISP or DOP were interpreted as signs of ventricular dysfunction consequent to the myocardial ischaemia induced by these amines. The use of ISP or DOP together with KCG is recommended as a diagnostic method for coronary insufficiency.

Adolescent↗
PubMedDate not supplied

Cold-induced rhinitis in skiers--clinical aspects and treatment with ipratropium bromide nasal spray: a randomized controlled trial.

Cold-induced rhinitis (CIR) is common among skiers and is perceived as a troublesome disease. We studied the clinical characteristics of CIR in a population of skiers and we evaluated the effectiveness of ipratropium bromide nasal spray (IBNS) in relieving symptoms in a double-blind placebo-controlled fashion. By means of specific questionnaires, we evaluated 144 subjects (69% men; mean age, 42.2 years). The prevalence of CIR was 48.6% and the distinctive symptom was rhinorrhea (96%), often severe. The prevalence of atopy was higher in the CIR patients (chi2; p = 0.004). Twenty-eight CIR subjects participated in a double-blind placebo-controlled cross-over trial for evaluating the effectiveness of IBNS (80 microg twice per day [b.i.d.]). The severity of symptoms was assessed by a visual analog scale, and the number of cleaning tissues used also was evaluated. The actively treated group showed a significant improvement of rhinorrhea (p = 0.0007) and a reduction in the number of cleaning tissues used (p = 0.0023). Only four mild local side effects were reported. We conclude that IBNS could be regarded as an optimal therapeutic option for treating CIR symptoms in skiers.

Adolescent↗