[Effect of surfactants on the in vitro enzymatic hydrolysis of chloramphenicol stearate].
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Biomedical subjects
Publications and source records attributed to G Coppi.
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The authors report the papaverine blood levels obtained after administration to a group of volunteers of a sustained-release preparation in comparison with a conventional form. The new preparation shows bioavailability equivalent to a normal papaverine but substantially more prolonged papaverine blood levels.
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Two schedules of treatment were adopted for an experimental evaluation of drug induced alterations in mid-small intestinal flora of normal rats. Test substances were given orally twice daily for 3 days at large doses and once daily for 30 days at lower doses. Indometacin, benzydamine, phenylbutazone, pheprazone, picosulfol, magnesium sulfate, tolbutamide, phenformin, dexamethasone acetate and prednisolone acetate were tested. Drug-induced alterations in rat intestinal flora resulted more evidently following multiple short-time treatments.
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