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Biomedical subjects

G D Pegrum

Publications and source records attributed to G D Pegrum.

At least 55 records · Page 3Linked to original sources
PubMed1973

Changes in antigenic nature of lymphocytes caused by common viruses.

Healthy human lymphocytes were incubated in the presence of influenza A2/Singapore/57, herpes simplex type 1, or adenovirus type 2. After two days the cultures were inactivated by irradiation. Fresh lymphocytes taken from the same donor were then found to react to the virus-treated cells in short-term cultures. We suggest that this reactivity is due to a change in the surface characteristics of the lymphocytes brought about by the presence of the virus. This may account for anomalous reactions in mixed lymphocyte cultures, and a similar effect in vivo might cause accelerated graft rejection.

Adenoviridae↗
PubMed1973

Nature of hyperacute (accelerated second set) rejection in dog renal allografts and effects of heparin on rejection process.

Renal allografts were exchanged between unrelated mongrel dogs after previous sensitization with skin and kidney grafts from the same donors. Rapid rejection of the renal allografts was associated with the accumulation of platelets and leucocytes in the peritubular and glomerular capillaries but fibrin deposition was not demonstrated.Heparin infusion delayed but did not prevent the rejection process.

Animals↗