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Biomedical subjects

G Dănilă

Publications and source records attributed to G Dănilă.

At least 19 recordsLinked to original sources
PubMed1996

Direct detection of the antioxidant activity of a new flavonic derivative using the chemiluminescence method.

The antioxidant potential of a new water soluble flavonic derivative, namely theophylline rutoside (TR-1722) has been tested using the chemiluminescence method. The method is based on the oxidative degradation of luminol by the hydrogen peroxide in Tris-HCl-buffer, when reactive species of oxygen are being obtained: O2-., HO., 1O2, and allows for the capability of substances to inhibit the free radical processes in this test system to be quantified and hence for their antioxidant properties in respect to a standard substance (in our case quercetin) to be compared. The results obtained reveal that TR-1722 has antioxidant action comparable to that of quercetin, the highest efficacity being registered at the concentration of 2 mumol/l, the conditions being: H2O2 16,2 mmol/l; luminol 2 mumol/l, in Tris-HCl buffer 20 mmol/l, pH 8.3. The antioxidant potential of TR-1722 is also maintained when the conditions of the system are modified, that is, the concentration of the hydrogen peroxide, the intensity of the action being dependent on the hydrogen peroxide concentration, but no direct proportionality is registered.

Antioxidants↗
PubMedDate not supplied

[Multiparticulate systems in the controlled release of active substances in the gastrointestinal tract].

The design of multiparticulate systems as carriers for molecules that have to be delivered at specific sites of the gastrointestinal tract must take into account the common events that govern this region. The intrusion of the multiparticulate systems has to face, by meanings of synthesis methods, or only by lack of aggressiveness the host system defences. Thus, non-specific and specific defence mechanisms are deployed to deal with the intruding material. Several strategies can be mentioned, as (a) prevent the contact and remove if contacted (b) kill if not remove, by the micro-fold cells that engulf bacteria and the gastrointestinal-associated lymphoid tissue. A physical barrier that adheres, prevents the contact, en-traps and removes the foreign matter is the mucus produced by the goblet cells.

Animals↗
PubMedDate not supplied

[Vanadium derivatives--a new source of antidiabetic drugs].

Vanadium, a transitional element belonging to Vb group is wide-spread both in vegetal and animal world. Although known by more a hundred years ago only in 1985 its hypoglycaemic properties were established. Recent research shown that the hypoglycaemic properties and the toxicity are influenced both by vanadium valence state and organic moiety that is binding it.

Animals↗
PubMedDate not supplied

[Researches on pharmacological properties of some new xanthine derivatives].

We studied the potentially bronhodilatatory action of some new xanthine compounds, theophylline derivatives with 7-[2-hydroxy-3-(4-acetamido)-phenoxy-propyl]-8-R-1,3-dimethyl-xanthine and 8-R-1,3-bis-(1,3-dimethyl-xanthin-7yl)-2-hydroxy-propane structure substituted in 7 and 8 position. The tracheal smooth muscle contraction we realized by carbachol (10(-5) M) or potassium chloride (40 mM), the xanthine compound being much active on the contraction induced by carbachol. We observed that the modification realised in theophylline structure determined the modification of bronchodilatatory properties. The bronchodilatatory effect of theophylline intensified with the introduction in 7 position the 2-hydroxy-3-(acetamido)-phenoxy-propyl and in 8 position the bromo, nitro, piperidinyl and imidazolyl radicals.

Analysis of Variance↗
PubMedDate not supplied

[Fluoroquinolones. Drug interactions].

This review summarizes clinically relevant drug-drug interactions for fluoroquinolones: antiacids containing aluminum and magnesium salts, iron or zinc preparations, sucralfate, cimetidine, ranitidine, warfarina, cyclosporin, rifampin, oral contraceptive steroids, benzodiazepine, probenecid, beta-lactam antibiotics, nonsteroidal anti-inflammatory drugs, metronidazole, theophylline, caffeine.

Animals↗
PubMedDate not supplied

Original method for nicorandil synthesis.

Nicorandil (N-(2-hydroxy-ethyl)-nicotine amide nitrate), drug recently introduced in therapy, is used as a vasodilator through potassium channel activation. Nicorandil is obtained by treating nicotinic acid chloride hydrochloride with nitro-oxy-ethyl-amine nitrate in an organic solvent. The authors suggest a method that uses ethyl nicotinate as raw material. Thus, the drug can be obtained from indigenous raw materials, at a lower price than the imported ones, with a high purity and a good yield.

Humans↗
PubMedDate not supplied

[Analytical study of theophylline-rutozide (TR-1722)].

A compound obtained by the semisynthesis of theophylline and rutozid was analysed elementary and physicochemically. The performed analyses showed that it was 7-rutozidil-is-propanolen-theophylline.

Anti-Inflammatory Agents, Non-Steroidal↗
PubMedDate not supplied

[Methodology for quality control of an ointment with antivaricose properties].

A personal formulation of an ointment with antivaricose properties is presented. A methodology for the physicochemical and rheologic control, including all parameters required by the standards for ointments quality control, was designed. The analyses showed that the ointment is stable in time, has a thixotropic consistency and behaviour and does not require special preservation conditions.

Chemical Phenomena↗
PubMedDate not supplied

[The semisynthetic production of pharmacologically active flavone derivatives. I. The pharmaco-toxicological properties of theophylline-rutozide (TR 1722)].

The pharmaco-toxicological properties of the compound theophylline-rutozide, termed conventionally TR-1722, are presented. Studied comparatively with aminophylline, it presents important advantages: soluble in water, the aqueous solutions have a pH close to the physiological one and are stable. It induces a weaker excitation on the central nervous system as compared to aminophylline, but its antihistaminic and anti-inflammatory properties are slightly increased. The physicochemical and pharmacological properties of TR 1722 recommend it for the patients with asthma and associated arterial hypertension or obstructive bronchopneumopathy associated with pulmonary hypertension.

Aminophylline↗
PubMedDate not supplied

[The synthesis and anti-inflammatory properties of 7-theophyllineacetic acid derivatives].

Some esters of 7-theophyllinylacetic acid were synthetized, characterized physicochemically and tested for their anti-inflammatory properties. As compared to indomethacin, reference anti-inflammatory drug, all synthetized compounds were less toxic. The anti-inflammatory properties are influenced by the nature of the ester group radicals, the more active having ramified alchils.

Animals↗
PubMedDate not supplied

[An analytical study of 2 dimethylxanthine derivatives with action at the level of the cardiovascular system].

The analytical investigation of two derivatives of dimenthylxantine series, conventionally termed Imfilin and Carprofilin, is presented. For the quantitative determination of these derivatives the authors suggest spectrophotometric methods in UV which gave good results in the physicochemical control of the substances and of certain pharmaceutical forms (injectable solutions, tablets). The suggested methods were applied in observing the stability of these pharmaceutical forms as well as in their determination in the biological material.

Cardiovascular Agents↗