Original method for nicorandil synthesis.

M Ungureanu; G Dănilă

PubMed · 12092148

Original method for nicorandil synthesis.

Abstract

Nicorandil (N-(2-hydroxy-ethyl)-nicotine amide nitrate), drug recently introduced in therapy, is used as a vasodilator through potassium channel activation. Nicorandil is obtained by treating nicotinic acid chloride hydrochloride with nitro-oxy-ethyl-amine nitrate in an organic solvent. The authors suggest a method that uses ethyl nicotinate as raw material. Thus, the drug can be obtained from indigenous raw materials, at a lower price than the imported ones, with a high purity and a good yield.

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Humans Nicorandil Potassium Channels Vasodilator Agents Journal Article

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M Ungureanu, G Dănilă. Original method for nicorandil synthesis.. https://pubmed.ncbi.nlm.nih.gov/12092148/

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