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Biomedical subjects

G DeCrescenzo

Publications and source records attributed to G DeCrescenzo.

8 recordsLinked to original sources

Ghosting caused by bulk charge trapping in direct conversion flat-panel detectors using amorphous selenium.

Direct flat-panel detectors using amorphous selenium (a-Se) x-ray photoconductors are gaining wide-spread clinical use. The goal of our investigation is to understand the physical mechanisms responsible for ghosting, i.e., x-ray induced change in sensitivity that results in image persistence, so that the knowledge can be used to consistently minimize ghosting artifacts in a-Se flat-panel detectors. In this paper we will discuss the effect on x-ray sensitivity of charge trapping in a-Se, which is the dominant source for ghosting in a-Se flat-panel detectors. Our approach is to correlate ghosting in electroded a-Se detectors with the trapped charge concentration measured by the "time-of-flight" (TOF) method. All measurements were performed as a function of radiation exposure X of up to approximately 20 R at electric field strength's of E(Se)=5 and 10 V/microm. The results showed that the x-ray sensitivity decreased as a function of X and the amount of ghosting decreased with increasing E(Se). The shape of the TOF curves changed as a result of irradiation in a manner indicating trapped electrons in the bulk of a-Se. The density of trapped electrons n(t) increases as a function of X. A method was developed to determine the values of n(t) in the bulk of a-Se from the TOF measurements, and to predict the corresponding change in x-ray sensitivity. Our results showed that a recombination coefficient consistent with that predicted by Langevin produced good agreement between calculated and measured x-ray sensitivity changes. Thus it can be concluded that the trapping of electrons in the bulk of a-Se and their subsequent recombination with x-ray generated free holes is the dominant mechanism for ghosting in a-Se.

Artifacts↗

Performance of a static-anode/flat-panel x-ray fluoroscopy system in a diagnostic strength magnetic field: a truly hybrid x-ray/MR imaging system.

Minimally invasive procedures are increasing in variety and frequency, facilitated by advances in imaging technology. Our hybrid imaging system (GE Apollo flat panel, custom Brand x-ray static anode x-ray tube, GE Lunar high-frequency power supply and 0.5 T Signa SP) provides both x-ray and MR imaging capability to guide complex procedures without requiring motion of the patient between two distant gantries. The performance of the x-ray tube in this closely integrated system was evaluated by modeling and measuring both the response of the filament to an externally applied field and the behavior of the electron beam for field strengths and geometries of interest. The performance of the detector was assessed by measuring the slanted-edge modulation transfer function (MTF) and when placed at zero field and at 0.5 T. Measured resonant frequencies of filaments can be approximated using a modified vibrating beam model, and were at frequencies well below the 25 kHz frequency of our generator for our filament geometry. The amplitude of vibration was not sufficient to cause shorting of the filament during operation within the magnetic field. A simple model of electrons in uniform electric and magnetic fields can be used to estimate the deflection of the electron beam on the anode for the fields of interest between 0.2 and 0.5 T. The MTF measured at the detector and the DQE showed no significant difference inside and outside of the magnetic field. With the proper modifications, an x-ray system can be fully integrated with a MR system, with minimal loss of image quality. Any x-ray tube can be assessed for compatibility when placed at a particular location within the field using the models. We have also concluded that a-Si electronics are robust against magnetic fields. Detailed knowledge of the x-ray system installation is required to provide estimates of system operation.

Electromagnetic Fields↗

alpha-Amino-beta-sulphone hydroxamates as potent MMP-13 inhibitors that spare MMP-1.

A series of alpha-amino-beta-sulphone hydroxamates was prepared and evaluated for potency versus MMP-13 and selectivity versus MMP-1. Various substituents were employed on the alpha-amino group (P(1) position), as well as different groups attached to the sulphone group extending into P(1)'. Low nanomolar potency was obtained for MMP-13 with selectivity versus MMP-1 of >1000x for a number of analogues.

Collagenases↗

SC-52151, a novel inhibitor of the human immunodeficiency virus protease.

SC-52151 is a potent, selective, tight-binding human immunodeficiency virus (HIV) protease inhibitor containing the novel (R)-(hydroxyethyl) urea isostere. The mean 50% effective concentration for lymphotropic, monocytotropic strains and field isolates of HIV type 1 (HIV-1), HIV-2, and simian immunodeficiency virus is 26 ng/ml (43 nM). The combination of SC-52151 and nucleoside reverse transcriptase inhibitors synergistically inhibited HIV-1 replication without additive toxicity. An extended postantiviral effect correlates with inhibition of gag and gag-pol polyprotein processing. SC-52151 is highly protein bound ( >90%) in human plasma, and the level of partitioning into erythrocytes is low. Physiological concentrations of alpha-1-acid glycoprotein, but not albumin, substantially affect the antiviral potency of SC-52151. The oral bioavailability of [14C]SC-52151 is 17% when it is administered as an elixir to the rat, dog, or monkey. Oxidation of the t-butyl moiety is the major route of biotransformation, and elimination is mainly by biliary excretion. No toxicologically significant effects have been observed in animals. Pharmacokinetic and metabolism studies in multiple animal species predict 20 to 30% systemic bioavailability, an elimination half-life of 1 to 2 h, and a volume of distribution of greater than 3 liters/kg in humans.

Amino Acid Sequence↗

A light source for testing radiological television cameras.

A light source for testing and setting up radiological television systems has been designed and built using green light emitting diodes and an optical integrating sphere. It is shown to have an optical spectrum similar to the green output phosphors used in x-ray image intensifiers (XRII's). It can be made uniform in intensity across the output port and does not show the small scale granularity characteristic of phosphors. It has a Lambertian angular distribution which, by the addition of neutral density filters, can be made to mimic the angular distribution at the output of an XRII. It can easily and accurately be modulated or switched and a luminance comparable to that of an XRII output phosphor can be achieved.

Lighting↗

Wiener noise power spectra of radiological television systems using a digital oscilloscope.

Measurement of spatial noise power spectra from television based radiographic and fluoroscopic systems is essential to the understanding of their operation and optimization. However, conventional methods require acquisition and processing of large numbers of complete images, thus confining such measurements to special applications where accessible frame buffers already exist or elaborately equipped laboratories. We have developed a method which only requires storage of single TV lines or point scans. A digital oscilloscope captures these point scans and a laboratory microcomputer facilitates manipulation of the data to separate out different components of the noise power spectra. The x-ray dependent component of the noise power spectrum so produced is not the ordinary Wiener spectrum. However, it is shown that reconstruction of the full Wiener spectrum from this is possible subject only to the requirement that the x-ray noise spectrum at the output of the imaging system is circularly symmetric.

Fluoroscopy↗

X-ray imaging using amorphous selenium: determination of x-ray sensitivity by pulse height spectroscopy.

There is a renewed interest in the application of photoconductors especially amorphous selenium (a-Se) to x-ray imaging. A new method for evaluating W +/-, the energy absorption necessary to release an electron-hole pair in a-Se is described. All previous methods used for the evaluation of the x-ray sensitivity of a-Se measure a change in surface potential on a charged plate due to irradiation by x rays. This results in a measurement of W +/- and other factors in combination. These factors include the energy absorbed from the spectrum of irradiating x rays and the a-Se layer capacitance. Such indirect methods are prone to error. A direct method for the evaluation of W +/-, which is based on the pulse height spectra resulting from the absorption of individual monoenergetic x-ray photons in a-Se, has been developed.

Humans↗