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Biomedical subjects

G Dimache

Publications and source records attributed to G Dimache.

At least 19 recordsLinked to original sources
PubMed1997

A clinical, epidemiological and laboratory study on avoiding the risk of transmitting viral hepatitis during vaccinations with the Dermojet protected by an anticontaminant disposable device.

Jet injectors may transmit blood-borne infections, such as hepatitis B virus (HBV) and human immunodeficiency virus (HIV). To evaluate the safety of an anticontaminant disposable device which protects the jet injector apparatus, 22,714 healthy subjects were intradermally inoculated (38,162 inoculations) with a variety of vaccines. All the subjects were systematically followed-up clinically and epidemiologically for 6-18 months after inoculation; blood samples from 1619 subjects, before and 60-75 days after inoculation, were examined by enzyme-linked immunosorbent assay (ELISA) for HBV, hepatitis C virus (HCV) and HIV. Before vaccination 212 (13.09%) subjects were positive: 204 positive for HBV markers and eight for the HCV marker. None of the subjects were positive for the anti-HIV marker. During the clinico-epidemiological surveillance and the laboratory investigations mentioned above no clinical viral hepatitis B or C case and no seroconversion to positivity for HBV or HCV markers among the susceptible persons in the group were reported. Considering that in similar situations there is a theoretical risk of transmission as high as 1 per 388 to 1 per 3367 injections and that in our case 38,162 inoculations were performed in 22,714 subjects with the same Dermojet protected by the same type of anticontaminant disposable device, no contamination risk being reported, the conclusion can be reached that jet injectors can be safely used in the medical practice if they are protected by the sterile anticontaminant disposable device.

Adolescent↗
PubMed1986

The comparative effectiveness, under epidemic conditions, of the intradermal versus subcutaneous antityphoid vaccination estimated by epidemiological surveillance and laboratory tests.

The inhabitants of a territory in which a severe epidemic of typhoid fever appeared, were immunized intradermally or subcutaneously with heat-inactivated phenol preserved typhoid vaccine. The great majority of individuals received booster doses during the following three years. The specific immunization together with other epidemiologic and hygienic measures resulted in a quick extinction of the epidemic and the reduction in time of the number of typhoid carriers; no case of typhoid fever occurred in the following ten years among the vaccinated subjects. These satisfactory epidemiological results obtained by the two methods of vaccination were in accordance with serological laboratory tests performed in parallel on two supervised groups of the local population. The intradermal typhoid vaccination by the Dermojet presented a number of advantages (economic and rapid administration of the vaccine, mild postvaccinal reactions, etc.) and displayed at least an equal efficiency as compared with the administration of the vaccine by the subcutaneous route.

Adolescent↗
PubMed1983

Lyophilized typhoid vaccine for intradermal use.

The prophylaxis of typhoid fever in Romania is usually achieved with fluid heat-killed phenolized vaccine. However the shelf life of this vaccine is only two years. The long term storage of an intradermal typhoid vaccine is made possible by lyophilization. A heat-inactivated bacterial suspension with a high concentration of organisms, at least 25 X 10(9) cells per ml, was freeze-dried at a temperature not higher than 30 degrees C. The final vaccine obtained had a residual moisture content of not more than 5%. Active and passive protection tests in mice, specific agglutinin production in humans and rabbits, the innocuity and the toxicity for mice, and the investigation of post-vaccinal adverse reactions in man, showed that the lyophilized typhoid vaccine could be stored at 4 degrees C for at least five years without loss of potency. Consequently, the vaccine may be stored without risk of deterioration for rapid emergency mass immunization with Jet-injector apparatus.

Animals↗