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Biomedical subjects

G F Adami

Publications and source records attributed to G F Adami.

At least 55 records · Page 3Linked to original sources

Intravenous nutritional support in pregnancy. Experience following biliopancreatic diversion.

11 pregnant women with protein malnutrition following biliopancreatic diversion for obesity were supported by parenteral nutrition (PN). In 2 cases high concentration glucose, lipid emulsions and standard aminoacid mixtures were infused via a central venous catheter; in the other subjects, because oral intake was normal or increased, only aminoacids with or without lipids were administered through a peripheral vein. PN promoted foetal growth and was very well tolerated and totally safe both for mother and infant.

Journal Article↗

Body composition in subjects with surgically obtained stable body weight normalization.

The body composition of lean control subjects was compared with that of subjects following biliopancreatic diversion for morbid obesity, when their excess weight had been stabilized at under 40 per cent of the ideal body weight value for over two years. Lean body mass, body cell mass and fat were indirectly calculated from total body water and total body sodium, measured by isotope dilution technique. The body composition in the two groups of subjects was essentially normal, as was indicated by the percentage values of the body composition parameters and by the linear correlations between body weight and the lean body compartments size.

Adult↗

Malnutrition, nutritional support and total body composition.

The nutritional status and total body composition of 33 patients with malnutrition after biliopancreatic bypass were studied. Body composition was evaluated directly by measurement of water and total sodium and indirectly by measurement of total body potassium. After nutrition with a parenteral nutritional support the conventional nutritional parameters were restored to the normal values (serum albumin and serum transferrin) and the parameters of body composition were markedly improved even though still altered with respect to healthy controls. Serum albumin and serum transferrin were shown to be very reliable indices of malnutrition but their normalization does not necessarily correspond to optimum body composition and thus to optimal normal nutrition.

Amino Acids↗

[Automated determination of total nitrogen in urine and feces].

Urine and stool total nitrogen was measured using the Carlo Erba Strumentazione NA 1500 nitrogen analyzer. Determinations were carried out on 10 mcl, 20 mcl and 50 mcl urine samples and on 20-50 mg stool samples. Both urine and stool data distributions were normal, thus indicating the reliability of the method. The NA and the classic Kjeldahl method gave very close results in the same urine specimen; slight and not significant differences were found in stool analysis, most likely caused by the poor homogeneity of the material. Due to the automation, they very short analysis time, the accuracy and the reproducibility of the results, NA 1500 can be used in clinical practice for nitrogen balance studies by direct measurement of losses.

Automation↗

[Total nitrogen concentration in human liver tissue. Correlations between morphological and microanalytical data].

The degree of hepatic steatosis and percentage total nitrogen content were evaluated simultaneously in a group of obese patients and after bypass surgery for obesity. The straight line relationship between sample weight and gas chromatographic response integrals shows that samples had the same water content. The higher concentration of total nitrogen in patients with higher levels of steatosis and the inverse correlation between degree of adipose infiltration and degree of total nitrogen, when water content is the same, suggest that the total liver parenchyma nitrogen concentration closely reflects the structural protein content.

Adult↗

[Effect of somatostatin on the rabbit Oddi's sphincter in vivo. Interrelation of somatostatin and cholecystokinin].

The action of somatostatin on the myoelectrical activity of the sphincter of Oddi was studied in anesthetized rabbits equipped with bipolar electrodes. The activity of the sphincter was recorded at the basal state and during 30 min after injection of somatostatin. After a bolus injection of somatostatin (1 to 8 micrograms/kg), the myoelectrical activity of the sphincter of Oddi decreased between the 2nd and the 10th min with a parallel decrease of the biliary pressure. These modifications were significant at the doses of 4 and 8 micrograms/kg only. There was a good dose-effect relationship. Moreover, the infusion of somatostatin (60 micrograms/kg/h) led to a decrease in sphincter activity. Bolus injection of cholecystokinin (2 UD/kg) under somatostatin infusion (60 micrograms/kg/h) induced an increase in the activity of the sphincter of Oddi. However, this activity never returned to basal levels.

Ampulla of Vater↗

[Evaluation of body composition in obese subjects].

The body composition of 12 obese patients was assessed. The dilution method was used to assess the total areas of sodium and water. Total potassium was measured indirectly using the following formula: total potassium = R X total body water-total body sodium, where R represents the contents in a whole blood sample. Both fat and muscle mass were found to be increased in the obese subjects. Examination of the total sodium/total water ratio and the relationship between weight and muscle mass, cellular mass and total fat showed the dimensional increase was harmonious.

Adipose Tissue↗

In vivo evaluation of immunological status after biliopancreatic bypass for obesity.

Cell mediated immunity was evaluated in vivo by means of the Multitest system in subjects at least one year after biliopancreatic bypass. Quantitative delayed hypersensitivity values were not significantly different between control, obese and partial biliopancreatic bypass subjects, while they were significantly (P less than 0.001) reduced in subjects who had total biliopancreatic bypass. The results demonstrate that cell-mediated immunity is not affected by partial biliopancreatic bypass, but that on the contrary, a severe immunosuppression follows total biliopancreatic bypass. A positive correlation between serum albumin concentration and Multitest score was found in all the operated patients.

Adult↗

In vivo evaluation of postoperative immunosuppression by means of Multitest system.

The Multitest System, a new standardized method for evaluating delayed hypersensitivity and cell mediated immunity was carried out before surgery and throughout the postoperative care in subjects undergoing gastrointestinal surgery. In all patients significantly depressed cutaneous reactions were found in the first day after operation. Immunosuppression lasted more than four days when postoperative infection has set up, while in uneventful patients delayed hypersensitivity has returned to preoperative values from the fourth day. It would be suggested that Multitest System data in fourth postoperative day could identify subjects with uneventful recovery after surgery.

Adult↗

The multitest system for delayed hypersensitivity evaluation. Standardized result in an Italian adult population.

Delayed hypersensitivity was evaluated by means of Multitest System in 50 healthy Italian adults. Results were checked for homogeneity, comparability and reliability assays. Strict antigen and technique standardization warranted closely homogeneous results. Booster effect did not occur. Data evaluation was not depending on individual reader. Multitest System appears to be the most reliable method to evaluate delayed hypersensitivity and cellular immunity in man.

Adult↗

Role of preoperative Multitest findings on predicting postoperative infectious complications.

On 100 patients undergoing gastrointestinal surgery, relationships between preoperative Multitest findings of delayed hypersensitivity and postoperative infectious complications were investigated. Multitest preoperative quantitative data, due to its strict antigen potency and standardization of technique, have shown to be reliable in excluding postoperative infections and they are also a good indicator in predicting them.

Evaluation Studies as Topic↗

Nine years' experience with end-to-end arteriovenous fistula at the 'anatomical snuffbox' for maintenance haemodialysis.

One hundred and seventy-seven end-to-end arteriovenous fistulas were created at the 'anatomical snuffbox' between 1 January 1972 and 31 December 1980. The survival rate of the fistulas was 83.1 per cent at 1 year and 46.3 per cent at 6.5 years; 10.2 per cent failed immediately. Local and general complications were virtually absent. Forty fistulas stopped functioning after a period varying from 10 days to 6.5 years following the operation. The main cause of late failure (50 per cent) was aneurysm formation due to repeated needle venepuncture at the same site and subsequent obliteration of the upper venous segment. The end-to-end anastomosis seems to be preferable to other techniques because of the absence of local vascular complications and a lower risk of cardiac embarassment. The 'anatomical snuffbox' site is convenient and spares the proximal vessels for reoperation if necessary.

Adolescent↗