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Biomedical subjects

G F Coloni

Publications and source records attributed to G F Coloni.

At least 55 records · Page 3Linked to original sources

[Staging of bronchogenic cancer. Determination of mediastinal lymphatic involvement using magnetic resonance].

Twenty-five patients with bronchogenic carcinoma were prospectively studied by both CT and MR during 10 days preceding thoracotomy. MR scans included contiguous axial and coronal slices. Results of CT and MR studies were compared with the surgical and pathological findings. Although no significant difference was found between the two imaging methods for the evaluation of mediastinal nodes. MR appear to be superior to CT in the aortopulmonary and subcarinal node areas.

Adult↗

[Importance of bronchial biopsy in the histologic typing of cancer of the lung. Case study contribution (1980-1987)].

The diagnostic significance of the histological typing of lung cancer carried out on preoperative bronchoscopic biopsy samples is assessed in relation to final morphological diagnosis on operating material. In this connection 176 of 624 cases of lung cancer documented histologically from January 1980 to December 1987 in which preoperative biopsy sample was followed by removal of the lung are analysed. The 4 basic histotypes of lung cancer according to the WHO (1981) classification are considered. A positive diagnosis for cancer was encountered in 138 cases (78.4%) with histotype confirmed in 122, whereas a negative diagnosis was encountered in 38 cases (21.6%). These findings also permitted further considerations, including the possible limitations of the technique.

Aged↗

[Lung cancer with mediastinal lymph node involvement. Results of the combination of surgery and radiotherapy].

From July 1979 to July 1986, 215 patients with non-oat cell carcinoma of the lung were treated by surgery at our institution. Of these, 169 had complete, potentially curative resection of their primary tumor and all accessible mediastinal lymph nodes. The extent of pulmonary resection consisted of pneumonectomy in 70 patients, lobectomy in 78 patients, bilobectomy in 18 patients and wedge resection in 3 patients. All were staged according to the AJG staging system. There were 88 patients without lymph node metastases (N0), 10 patients with peribronchial lymph node metastases (N1) and 60 patients with regional lymph node metastases (N2). All patients with N2 disease received radiation therapy to the mediastinum after surgery. The overall survival rate was 62% at 1 year, 36% at 3 years and 27% at 5 years. Survival in patients with N2 disease was 56% at 1 year, 23% at 3 years and 12.4% at 5 years. We conclude that patients with mediastinal lymph node metastases can be effectively treated by combined resection and radiation therapy, with prolonged survival.

Adult↗

[Evaluation of carcinoembryonic antigen (CEA) in the follow-up of patients with inoperable lung cancer undergoing polychemotherapy].

Twenty-two patients with surgically incurable lung cancer undergoing systemic chemotherapy have been studied with serial determinations of CEA levels during their therapy. The changes of CEA levels in each patients showed that the assay may be useful to evaluate the effects of therapy. The purpose of this preliminary study is to explore the possibility that CEA assay may be a useful guide to the subsequent clinical response of the patient to the drug.

Carcinoembryonic Antigen↗

Preliminary observations on lung cancer therapy by interstitial irradiation with iodine 125.

Interstitial implantation of I125 by thoracotomy represents a further therapeutic procedure for lung cancer. Two cases recently treated by this procedure are reported. The first case concerns a right apical carcinoma of the lung where interstitial implantation of I125 seeds was carried out in the unresectable apical neoplastic residue, after superior lobectomy. The second case concerns a smaller tumor unresectable due to the severely impaired respiratory function. Main indications to the procedure are reported.

Aged↗

Present tendencies in the surgical treatment of pectus excavatum.

Among the malformations of the chest wall, pectus excavatum is undoubtedly the most frequent. It may appear in various forms and may show varying degrees of severity. Surgical correction by operation is mostly sought by the patients for aesthetic reasons. After careful review of the methods proposed by various writers for the correction of this malformation, the present writers emphasize the advantages and disadvantages of these techniques, especially in relation to the methods of stabilising the reduction. Finally, they report on their own case material and present some significant examples.

Adolescent↗

[Pre- and postoperative treatment of pulmonary suppuration].

A group of patients presenting a pathology of pulmonary suppuration is examined and a type of basic treatment used for preparing such patients for surgery, not always indicated by suppuration, is presented. A number of clinical and functional parameters measured before and after such treatment are also examined. The therapy carried out personally in the immediate postoperative period and in the long term is illustrated.

Cephalexin↗