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Biomedical subjects

G Falck

Publications and source records attributed to G Falck.

58 records · Page 4Linked to original sources
PubMedDate not supplied

Protective effects of repetitive injections of radiographic contrast media on the subsequent tolerance to ischemia in the isolated rat heart.

PURPOSE: Despite detailed knowledge of the effects of X-ray contrast media on cardiac function, no studies have examined the effect of contrast media injections on the subsequent tolerance to ischemia in the heart. METHODS: Isolated perfused rat hearts were exposed to repetitive injections of iohexol, iodixanol, or ioxaglate before 30 min of global ischemia and 120 min of reperfusion. These groups were compared with control (no pretreatment) and ischemic preconditioning known to reduce infarct size. Physiologic variables and infarct size were measured RESULTS: Pretreatment with iodixanol reduced infarct size significantly compared with control and thus afforded protection against ischemia. Injections with iohexol and ioxaglate reduced infarct size, although not significantly, compared with control. CONCLUSION: Pretreatment of the isolated rat heart with commonly used contrast media enhances the cardiac tolerance to subsequent ischemia. The mechanism behind this protective effect could not be determined, but could involve stretching of the heart and/or generation of nitric oxide.

Animals↗
PubMedDate not supplied

Sudden infant death syndrome: postmortem findings of nicotine and cotinine in pericardial fluid of infants in relation to morphological changes and position at death.

Parental smoking is considered to be an important risk factor for the sudden infant death syndrome (SIDS). We studied the concentrations of nicotine and cotinine in the pericardial fluid of SIDS and non-SIDS victims, with particular emphasis on the relationship to body position at the time of death and organ pathology. Pericardial fluid was collected during a forensic postmortem examination of 85 nonselected infants, under the age of 1 year, who died from SIDS (n = 67) and non-SIDS (n = 18) in the period from 1988 to 1994. There was no significant difference in the pericardial concentration of nicotine and cotinine between SIDS and non-SIDS victims. However, in contrast to non-SIDS victims, about 25% of the infants in the SIDS group had cotinine concentrations exceeding 30 ng/mL, indicating tobacco exposure prior to death. High concentrations of cotinine were found in infants with focal necrosis and inflammatory changes in the myocardium and the liver. Further, a relationship was found between high nicotine concentration and otitis media and also with death while cosleeping.

Body Fluids↗