The morphopathogenesis of lesions induced by high doses of isoproterenol injected for 1-7 days and 1-3 months is dynamically studied in groups of Wistar rats and guinea pigs. The disseminated myocardial necroses induced were of a hypoxic nature. By cicatricial substitutions, lesions of cardiosclerosis similar to those observed in pheochromocytoma cases were obtained.

Animals↗

PubMedDate not supplied

Dysfunctional endometrium in primary and secondary sterility. An optic and electronmicroscopic study.

Endometria from women with primary and secondary sterility were morphologically, optically and ultrastructurally studied; such endometria were selected by clinical and paraclinical methods. In dysfunctional endometria the most important modification consists in the perturbation of the cyclical maturation process of the epitheliostromal components, perturbation which may take place "synergically" or it may be "dissociated", in disagreement with the theoretic day of the menstrual cycle. Such perturbations took place in varied circumstances: "out of phase", luteal deficit associated with hyper- or hypoestrogenemia, or pure luteal deficit, receptivity disorders, association with specific or unspecific inflammatory lesions, anovulatory cycle. Endometrium biopsy constitutes the best method for the diagnosis of endometrial dysfunctions, showing both the ovary's global hormonal function, and the qualities of the endometrial receptor, with the corrective of the corresponding technical processes and the compulsory knowledge of some clinical data.

Adult↗

PubMedDate not supplied

Morphophysiological studies in experimental myocardial stress induced by isoproterenol. Note II. The myocardioprotector effect of magnesium ascorbate.

The efficiency of magnesium ascorbate, a new Romanian cardioprotector drug, was studied in guinea pigs and Wistar rats, both normal and with scurvy, within the framework of morphophysiological investigations of the pathogenesis of myocardial disease induced by large doses of beta-adrenergic substances of the isoproterenol type. The preventively treated animals presented only disseminated myocardial ultrastructural lesions within reversible limits. Biochemically, as compared with controls, a return to normal levels of ATP and Mg2+ and a decrease in the uptake of 45CaCl2 by the myocardium were observed. The pharmacological mechanisms of action of magnesium ascorbate are discussed.

Animals↗

PubMedDate not supplied

Myocardial lesions in experimental acute heart failure.

The present study concerns the morphological and biochemical lesional picture of the myocardium in cases of acute heart failure induced by various experimental models: ligature of the coronary artery, direct electric stimulation of the heart by catheterism, lethal hemorrhage, pneumothorax, beta-adrenergic shock. Worthy of note was the similitude of the lesional myocardium pictures characterized electron microscopically by a wide range of lesions, from reversible to focal cytolysis, and biochemically by decrease of mitochondrial enzymes, ATP, Mg2-1 X K+ and increase of Na+ X H2O, Ca2+. Problems linked to the pathogenesis, reversibility of the lesions and efficiency of certain therapeutical means are discussed.

Acute Disease↗

PubMedDate not supplied

Experimental investigations in prolonged myocardial ischaemia. Note I. Biology of the myocardial fiber after transient myocardial fiber after transient myocardial ischaemia.

The first ten days' evolution of post-ischaemic lesions of the premonitory or angina pectoris syndrome type was experimentally studied by the challenge of a short-term (10 and 15 min) ischaemia, of an adaptation to ischaemia and an adaptation followed by prolonged ischaemia (20 and 35 min). Worthy of note was the persistence of reversible lesions after short-term ischaemia and adaptation, and the progressive evolution towards cytolysis and cicatrization of some pancicellular foci after adaptation followed by prolonged ischaemia. The role of mitochondrial lesions, of lysosomal hydrolases, the inefficiency of renewed circulation, as well as problems of diagnosis are discussed.

Angina Pectoris↗

PubMedDate not supplied

Experimental investigations in prolonged myocardial ischaemia. Note II. Biology of the myocardial fiber during permanent ischaemia.

The dynamics of morphologic and biochemical lesions of the myocardial fiber during the first ten days after an experimental myocardial infarction showed an unequal evolution of the lesional picture in the ischaemic area, the intervention of lysosomal hydrolases and the reactions of inflammatory fibrocollagen substitution. Morphologic aspects in the areas neighbouring the infarction and other myocardial areas are discussed.

Animals↗

PubMedDate not supplied

Down's syndrome 47, XX,+21 with agonadism.

A girl with 47, XX,+21 Down's syndrome presenting labio-scrotal fusion and clitoral hypertrophy is reported. Anatomo-pathologic examination of the patient revealed the absence of the gonads and rudimentary Fallopian tubes. Botal's orifice was also present. This association, the first to be encountered so far, seems fortuitious.

Chromosome Mapping↗

PubMedDate not supplied

[Adaptation of the myocardium to ischemia: study of suspension of the mitochondria as related to the development of the collateral circulation].

The authors developed an experimental model by means of which they established in the dog the role of short duration ischaemia (1-5 minutes) in triggering local haemodynamic changes that led to the rapid development of a collateral circulation, with retrograde filling, able to furnish subsequently blood supply to the distal segment of a main coronary artery obstructed for 20 minutes. Histological study, electron microscopy, biochemical tests and mitochondrial suspensions revealed the value of the latter method, being the most reliable test for appraising the remaining postischaemic functional potential. The data obtained may serve as a basis for understanding the role of the coronary colateral circulation in man, in coronary obstruction, and the means of developing this circulation.

Animals↗

PubMedDate not supplied

[Possibilities of surgical treatment in hemophiliac arthropathy].

The possibilities are discussed of the surgical treatment in haemophiliac arthropathies. The cases that have been treated totalled 11 patients with type A haemophilia and one patient with type B haemophilia. The treatment was aimed either at an arrest of deterioration in the involved joint (in the early, I and II stages), or at correcting the vicious positions that had developed in the late stages (III and IV).

Adolescent↗

PubMedDate not supplied

Investigations on the morphophysiological basis of revascularization of the myocardium by the Vineberg method.

A study was carried out on the dynamics of vasculogenesis and the formation of mammary-coronary anastomoses within the first seven months after implantation of the internal mammary artery in the left ventricular myocardium, according to the Vineberg method. The efficiency of these anastomoses was demonstrated 4 to 7 months later by the absence of lesions 8 to 10 days after transitory and permanent myocardial ischaemia induced by coronary obliteration. The lesions could not be prevented in the case of thrombosis of the internal mammary artery or when ischaemia was produced concomitantly with the implant or before the mammary-coronary arteriolo-arterial anastomotic network developed.

Animals↗

PubMedDate not supplied

Ultrastructural and biochemical alterations induced by propranolol treatment in experimental myocardial ischaemia.

The effect of propranolol within the first ten days after a transient experimental myocardial ischaemia was investigated. As compared to the untreated control lot, the ultrastructural and biochemical lesions appeared to be much reduced and within reversible limits. Worthy of note was the slight affection of mitochondria revealed by the level of mitochondrial enzymes, the presence of lysosomal and phagolysosomal structures and capillaries of normal aspect, and the absence of cytolysis. The favourable effect of this beta-blocking drug might be attributed to its protective action on the cellular and capillary membrane systems.

Animals↗

PubMedDate not supplied

Experimental research on chronic poisoning by "carbofuran".

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Animals↗

PubMedDate not supplied

Interference of some enzymatic modulators in the hepatic aggression induced by xenobiotics.

The aim of the paper was to compare the erythrocyte serum and hepatic chomogenate antioxidative factors in order to assess their involvement in the detoxification events. The catalase and superoxiddismutase levels, important factors of the cellular defence, were sensitivity modulated in an acute experiment on Wistar rats. Carbofuran was administered in a non-lethal dose (7 mg/b.w.) single or in the presence of certain antioxidative agents (Vitamin E, Caffeine, Aspirin) EDTA and Cysteine for their role in protecting membranes against oxidative damage. The erythrocyte parameters (SOD, Catalase) were well related to seric factors, especially ceruloplasmin level, with varied magnitudes. GGT a marker of hepatotoxicity and G1-DH, a mitochondrial marker, were in a good correlation with erythrocyte factors. The changes seem to modulate a transmembranary disturbance process, as in hepatocyte pictures.

Animals↗

PubMedDate not supplied

[The place and value of the extemporaneous histopathological examination in surgery].

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Diagnostic Techniques, Surgical↗