Structure determination of the primary renal metabolite of the penem FCE 22101.
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Animals↗
Biomedical subjects
G Franceschi
Publications and source records attributed to G Franceschi.
Novel quaternary ammonium penems: the [(pyridinio)methyl]-phenyl derivatives.
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Animals↗
2-(quaternary ammonio)-methyl penems.
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Cephalosporins↗
Identification of urinary metabolites of rifamycin LM 427 in man.
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Humans↗
Physico-chemical properties of FCE 22250, 3-(piperidinomethylazinomethyl)rifamycin SV, a new long-acting rifamycin.
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Chemical Phenomena↗
Novel rifamycins. IV. 3-Aminomethylazinomethylrifamycins, a new class of rifamycins, endowed with remarkable antibacterial activity.
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Animals↗
A new class of penems, the 2-heterocyclyl(thio)methyl derivatives.
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Anti-Bacterial Agents↗
Novel rifamycins. III. Synthesis and antibacterial activity of 3-amidino- and of 4-aminoimidazolo[4,5-c]rifamycin derivatives.
A number of semisynthetic rifamycin derivatives modified at position 3 and/or 4, belonging to general structures 2 and 4 (see Scheme 1), have been obtained. The synthesis and the biological activities of the new compounds are described. Compounds 4p and 4q display very good antimycobacterial activity in mice.
Animals↗
Synthesis and biological properties of sodium (5R, 6S, 8R)-6 alpha-hydroxyethyl-2-carbamoyloxymethyl-2-penem-3-carboxylate (FCE 22101) and its orally absorbed esters FCE 22553 and FCE 22891.
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Administration, Oral↗
Biological activity of (5R,6S,8R)-6-alpha-hydroxyethyl-2-acetoxymethyl-2-penem-3-carboxylate.
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Anti-Bacterial Agents↗
Unusual rearrangement of 3-hydrazino-rifamycins leading to the enlargement of the "natural" ansa bridge.
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Hydrazines↗
Semisynthetic aminoglycoside antibiotics. IV. 3',4'-Dideoxyparomomycin and analogues.
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Bacteria↗
Novel rifamycins. I-Synthesis and antibacterial activity of 3-hydrazinorifamycin derivatives.
A number of semisynthetic rifamycin derivatives, modified at position 3, belonging to general structures (II), (III), (IV), (V), (VI), (VII) and (VIII) (see Scheme), have been prepared. The synthesis, structure, and antimicrobial evaluation of the new compounds are described. All the derivatives have in vitro antibacterial activities comparable with that of rifampicin.
Bacteria↗
New rifamycins. II. Synthesis and biological activity of oximes, hydrazones, and semicarbazones of 3-N-(piperidin-4-one)rifamycin S.
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Bacteria↗
Semisynthetic aminoglycoside antibiotics. III. New deoxy derivatives of paromomycin.
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Anti-Bacterial Agents↗
Antibacterial activity of novel broad-spectrum "(5R)-penem" derivatives.
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Animals↗
In vitro and in vivo evaluation of benzamidomethyl-benzylpenicillinate (FI7303). A new 'repository' form.
A new type of hydrolyzable ester of penicillin G, benzamidomethyl benzylpenicillinate (FI 7303), was studied for the antibacterial activity and kinetics of absorption in comparison with DBED-penicillin G. FI 7303 resulted to be a good repository form of penicillin G, slowly eliminated in mouse, dog and man. It exerted a remarkable therapeutic activity in mice infected with Staphylococcus aureus even when administered 26 h before infection. The protective effect in mice was more prolonged than that of DBED-penicillin G, in agreement with the longer persistence of significant blood levels.
Absorption↗
Semisynthetic aminoglycoside antibiotics. I. New reactions of paromomycin and synthesis of its 2'-N-ethylderivative.
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Bacteria↗