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Biomedical subjects

G Franceschi

Publications and source records attributed to G Franceschi.

52 records · Page 3Linked to original sources
PubMed1978

Studies related to the metabolism of ergoline drugs. Structure determination and spectroscopic properties of 1,6-dimethyl-12-hydroxy-10alpha-ergoline derivatives.

The structure of some 1,6-dimethyl-12-hydroxy-10alpha-ergoline derivatives, related to an active metabolite of metergoline, is established by using physical methods (mass spectrometry, electronic and fluorescence spectroscopy, and 1H N.M.R. spectroscopy). The 13C N.M.R. spectrum of compound (II), 1,6-dimethyl-8beta-(acetylaminomethyl)-12-hydroxy-10alpha-ergoline, is analyzed.

Chemical Phenomena↗
PubMedDate not supplied

Radioimmunotherapy trials in germ testicular carcinoma: a phase I study.

Two patients with germ cell testicular cancer were submitted to radioimmunotherapy (RIT) by using the monoclonal antibody 131I-radiolabelled (MoAb) H17E2, raised against placental alkaline phosphatase (PLAP). Both patients had been previously treated with repeated chemotherapy regimens assisted by autologous bone marrow transplant (ABMT), that, in the end were unsuccessful, thus necessitating further experimental treatment. RIT was well tolerated and the targeting of multiple neoplastic lesions was satisfactory. Nevertheless, the clinical results of treatment were minimal owing to the extension of the tumour. The data obtained suggest the possibility of applying this form of treatment in patients with minimal residual disease after previous traditional chemotherapy regimens.

Adult↗
PubMedDate not supplied

Radioimmunotherapy of gastrointestinal cancer and glioblastomas.

Two groups of patients with gastro-intestinal (GI) tumours (41) and recurrent glioblastoma (GBM), (17) underwent radioimmunotherapy after the failure of traditional treatments. A number of different MAbs were employed (anti-CEA and anti-Tenascin) which were labelled with I-131. The radiopharmaceuticals were administered by the intraperitoneal and intratumoral routes. As a rule the cycles were repeated to enhance the effectiveness of RIT. No significant early or late adverse effects were recorded. HAMA development was observed in all GI cases but only in a few GBM patients. The cumulative dose delivered to the target tumors was considerable (mean 8,900 cGy) in the GI group, and was much higher in the GBM patients (mean 51,700 cGy) owing to the particular modality of injection. Survival improved in both series of patients. The objective responses to RIT were promising: in the GI group 10 complete remissions (CR) and 6 partial remissions (PR) were observed, while in the GBM group 3 long-lasting CRs and 3 prolonged PRs were documented.

Brain Neoplasms↗
PubMedDate not supplied

Immunoscintigraphy of primary and metastatic colorectal cancers with radiolabelled monoclonal antibodies anti-CEA.

Thirteen patients with a diagnosis of primary colorectal tumour and 68 patients previously operated for colon cancer underwent an immunoscintigraphy carried out with monoclonal antibodies anti-CEA F(ab')2, labelled with 131I or 111In. These studies led to the detection of all primary tumours and of most of their associated lesions (7/8). In this group 15 neoplastic deposits previously undetected were demonstrated, allowing an improvement in the patient staging before the operation. In the group of the 68 operated patients, immunoscintigraphy succeeded in imaging 96 out of 121 known lesions: the best outcomes were obtained for abdominal and pelvic recurrences as well as for lymph nodes lesions. The lowest levels of sensitivity were observed for liver metastases. An enhancement of the immunoscintigraphy sensitivity was obtained when the radiopharmaceutical was injected intraperitoneally. In 50 patients, this alternative administration route was successful in detecting 91/107 cancer deposits and, in particular, liver metastases were found out in 36/42 cases.

Antibodies, Monoclonal↗
PubMedDate not supplied

The long gamma nail: indications and results.

The authors report their experience concerning the use of the long gamma nail in 18 cases with the following indications: double fractures of the proximal end and the diaphysis of the femur; subtrochanteric fractures and of the diaphysis with severe lesion of the medial cortical bone; subtrochanteric pathologic fractures. All of the fractures except one consolidated within 6 months and weight-bearing was allowed early. Breakage of the means of synthesis was the only major complication observed. The long gamma nail has proven to be an irreplaceable method for the treatment of associated fractures of the proximal end and of the femoral diaphysis.

Adolescent↗