PubMed Health⌕ Search

Biomedical subjects

G Frick

Publications and source records attributed to G Frick.

At least 37 records · Page 2Linked to original sources
PubMed1985

[Erythrocyte-associated plasma proteins, a further aspect of erythrocyte function?].

The amount of plasma proteins associated to erythrocytes was determined or calculated by using three different techniques. Thus, there are 3.48 X 10(12) g of protein in a single erythrocyte or 94.12 g of protein respectively in the total of all erythrocytes in a healthy man with a body weight of 70 kg. The mass of plasma protein associated to erythrocytes will decrease in case of immunocomplex aggregates or otherwise denatured plasma proteins being fixed to the erythrocyte surface so that from a purely calculating point of view protein amounts on a scale of up to 46% of all plasma proteins may enter the free blood plasma under extreme conditions. In this, an immediately efficient possibility of compensation is seen by the authors in case of an acute consumption of blood proteins.

Antigen-Antibody Complex↗
PubMed1985

[The plasma protein film on rat erythrocytes after application of methylcholanthrene].

By means of a special procedure of preparing and colouring blood smears of adult male Wistar rats the plasma protein film (PPF) on erythrocytes was investigated before and after injecting 3 mg of 20-methylcholanthren per animal. It was as early as on the 14th day post injection that a significant alteration of PPF towards initial and control values could be found. Causes and possible consequences are discussed.

Animals↗
PubMed1985

New aspects in the pathogenesis of infectious and tumor anaemia.

From new evidence of increased adhesion of immune complexes in the plasma protein film of erythrocytes, the pathogenesis of tumor anaemia and anaemia in chronic infections is suggested to be a mechanism of the early sequestration of the erythrocytes by erythrophagocytosis following their coating with immune complexes and denaturated immunoglobulins.

Anemia, Hemolytic, Autoimmune↗
PubMed1985

[Visual classification of erythrocytes in blood smears from normal subjects and patients].

Erythrocytes on specially prepared and coloured blood smears can be classified not only by idcture analysis but also by phase contrast microscopy. Parameters of change for the peripheral zone area and pallor area (phase contrast value PW and index of erythrocyte changes Ev-I) serve as classificators of visual technique. 449 blood smears of the same number of male and female grown-up persons, whose diagnosis was unknown at the time of evaluation, were used for evaluation. In 145 cases these were healthy test persons in clinical and laboratory respect (group I). 163 test persons were ill, but without any malignous neoplasias (group II), and in 141 patients an ensured malignous neoplasia could be found (group III). From those 308 test persons or patients respectively in group I + II 11 blood smears were falsely classified as positive (= 3.6%). In 5 from 141 cases in group III blood smears were falsely evaluated as negative (= 3.6%). The findings were statistically ensured by the t-test. Clinical parameters of evaluation gained with visual techniques of classification are in accordance with those gained with automatic picture analysis. The reasons for the good separating ability of PW and Ev-I are discussed. Visual techniques of classification are suitable for institutions of all grades of equipment.

Adult↗
PubMed1984

A microprocessor-based system for measurement of gas exchange.

The basic physical measurements for determining gas exchange are difficult to make accurately even in a well-equipped, human-performance laboratory with experienced personnel. A fully automated system has been developed to achieve the accuracy of standard laboratory measurements. The application of this instrument extends from critical care to stress-testing. Real-time, multitasking software integrates the data collected from several transducers and analyzers and calculates up to several dozen physiological variables, which are range-checked for reasonableness. The operator is provided with user-friendly means to tailor the data-reporting and- collection functions of the system to his own needs and requirements. Because the instrument is controlled by software, the functions of calibration, measurement, timing, reporting, plotting, and data quality assurance are highly cost-effective. Extensive use of formal test procedures permits verifying all systems and data reliability; it also assures meeting the desired specifications. The ease of operation and high-quality results inherent in this system make it unsurpassed in gas-exchange measurements.

Computers↗
PubMed1984

[Relations between parameters of lipid metabolism and hemostasis in vascular diseases].

In 98 patients with arterial insufficiency of arteriosclerotic and diabetic genesis correlation analyses were carried out between total cholesterol, HDL cholesterol, triglycerides, creatinine, blood pressure, platelet counts, platelet function and antithrombin III. Besides the known relations between the parameters of lipid metabolism and blood pressure, correlations were found and analysed between antithrombin III, platelet function, renal function and between platelet counts and HDL cholesterol. The importance of the findings for the diagnosis of vascular insufficiency and the relation to normal values are discussed.

Antithrombin III↗
PubMed1983

[Effect of ultraviolet ray irradiation of blood on thrombocyte function and cholesterol level].

Action of the ultraviolet irradiation of autologous blood on thrombocyte function and serum cholesterol values. By means of a screen pressure measurement in vitro in patients with arterial occlusive disease during the course of treatment with ultraviolet irradiation of autologous blood a normalisation of thrombocyte functions is evident. This effect lasted up to a year after beginning of treatment. In the same time a significant diminuation of serum cholesterol levels appeared. The course of these parameters permits a theoretical confirmation of the observed good clinical long term effects of the ultraviolet irradiation of autologous blood and corroborates the acceptability of this therapy in cardiological and vascular dispensaires.

Arterial Occlusive Diseases↗
PubMed1983

[Modification of uremic thrombocytopathy by hemodialysis].

By means of in vitro screen pressure measurement the functions of thrombocytes were detected in dialysis patients before and immediately after dialysis. Start values are below the normal region as a sign of uraemic thrombocytopathia. The expected improvement after dialysis was not to be seen. As a cause of deterioration an activation of the thrombocytes at the surfaces of the capillary kidney and an incomplete inhibition of this process by heparin is discussed.

Blood Platelet Disorders↗
PubMed1983

[Picture series table for marker classification of the structure of erythrocyte marginal bands on specially prepared blood smears].

A phase-contrast microscopic procedure of evaluation, measurement and classification which can be simply performed on erythrocyte marginal zones (ERZ) of particularly prepared and coloured smears is described. Classification is made with the help of a classification table and a picture series table after measuring the erythrocyte marginal zones with an ocular measuring plate or with a measuring screw ocular respectively. The same preparing and colouring technique also enables erythrocyte marginal zones to be evaluated with an automatic picture analysis and with the scanning electron microscope. With the help of this technique, which can be applied in human erythrocytes as well as in those of dogs, rats and fish, changes of erythrocyte margin zones which may be caused by haematological, immunological and toxicological processes may be determined in quantity. The mode of action of this preparation technique is dealt with in the discussion.

Animals↗
PubMed1983

[New aspects of therapy with blood and blood components].

For diminishing transfusion risks and for ethical and economical reasons a rational hemotherapy is indispensable. The "Berner model" referred to here contains an acceptable explanation. It is evident that the overwhelming part of surgical interventions is accomplished by using erythrocyte concentrates. Therefore, fresh whole blood and fresh frozen plasma are better available. Coagulational active plasma fractions have unchanged indications for a rational substitution of coagulation factors. New indications for some blood components are described.

Blood Coagulation Factors↗
PubMed1982

[Effects of ethinyloestradiol sulphonate in soft-gelatin capsules on coagulation parameters of weaning women (author's transl)].

Two groups of 16 puerperae each with and without low doses of ethinyloestradiol sulphonate in soft-gelatin capsules were involved in studies into coagulation parameters as well as into basophilic leucocytes and antithrombin III.--No statistically significant difference was found to exist between the two groups. Both the basophils and antithrombin III were strongly reduced in the two groups.

Blood Coagulation↗