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Biomedical subjects

G Frick

Publications and source records attributed to G Frick.

At least 73 records · Page 4Linked to original sources
PubMed1976

[The course of total leukocytes and heparinocytes in the normal puerperium and during weaning under ethinyl estradiol sulfonate].

The inhibition of lactation by the depot oestrogen aethinyloestradiolsulfonate was accompanied by a delayed drop of the puerperal leukocytosis. Values of heparinocytes and Basophil-Age-Indices (BAI) were not significantly influenced. The reaction of the heparinocytes system is different in increasing classes of age. By depotoestrogens in the puerperium the princip of this reaction is not changed. Results don't support the hypothesis of influence of oestrogens upon puerperal and hormonal contraception risks of thromboembolism.

Basophils↗
PubMed1976

Relations between fibrinogen degradation products and heparinocytes.

In the emergency reaction there is a short-time increase of the values of basophilic leukocytes in connection with normal values of fibrinogen degradation products (FDP). After diminuation of basophils FDP are to be detected. In the chronical ill and under different hormonal contraceptives these two processes are overlapped disturbing a unique negative or positive correlation of heparinocytes and FDP. Concerning the situation under standardized conditions or in single cases worthful conclusions are possible about compensation or decompensation of a latent disseminated intravascular coagulation.

Arterial Occlusive Diseases↗
PubMed1976

[Behavior of the heparinocytes after gold therapy].

A reduction of the total leukocytes as well as a significant decrease of heparinocytes and BAI (basophilic age index) can be observed in rheumatoid arthritis in the course of a gold therapy. As some coagulation parameters simultaneously speak in favour of an enhancement of the intravasal coagulation, a partial blocking of the endogenous heparin caused by gold may be supposed. A combined heparin or heparinoid therapy in a low dosage is being recommended for risk patients of the vascular and coagulation system.

Arthritis, Rheumatoid↗
PubMed1976

[Thrombocyte kinetics before and after gold therapy in rheumatoid arthritis].

Before and after performing a basic therapy with sanocrysin, thromboytic kinetic examinations were carried out in 12 patients suffering from rheumatoid arthritis. The thrombocyte survival time, maximal recovery and thrombocyte turnover were determined. The surface activity values were given in the form of spleen-heart quotients and liver-heart quotients as well as by surplus impulses over these organs. The findings evaluated statistically reveal that even the untreated rheumatoid arthritis will have thrombocytic kinetics deviating from the norm. By influencing RES the gold treatment will lead to an reduction of the enhanced platelet decomposition. The behaviour of single parameters before and after gold therapy are discussed. The examination of thrombocyte kinetic could not identify a damage of thrombopoiesis in the bone-marrow and in the periphery caused by sanocrysin.

Arthritis, Rheumatoid↗
PubMed1976

[Fibrinolysis before and after gold therapy in rheumatoid arthritis].

In 12 patients with chronic rheumatoid arthritis the immunoglobulins IgG, IgA and IgM were determined according to Mancini and the fibrinolytic split products according to Nilehn before and after a gold treatment of 3 to 6 months. The IgG values were always increased and even after the treatment there was only little regression. The fibrinolytic split products found in 5 cases speak in favour of an enhanced intravasal coagulation, which increased still further after the gold therapy. In spite of clinical improvement the immunological processes and latent actions of coagulation seem to pass almost undiminished.

Arthritis, Rheumatoid↗
PubMed1976

[Hormonal contraception--throboembolism and surgical risk].

Epidemiological, coagulational, haemodynamical, and morphological studies are critically analysed in this review. Our attitude about the surgical operation risk under hormonal contraceptives is explained. In smaller operative measures there musn't be a break in hormonal contraception. Planned greater operations are to performe only 4 to 6 weeks after cessation of hormonal contraceptives, i.e., after the first spontaneous menstrual bleeding. Hints for the necessity greater operations without a removal after pill or an additional risk factors are given.

Arterial Occlusive Diseases↗
PubMed1976

[Behavior of heparinocytes and of fibrinolytic degradation products after discontinuation of hormonal contraceptives].

After cessation of hormonal contraception a quick adaptation of the heparinocyte values to the normal menstrual phase course appears, but the values occur at a higher level. Fibrinolytic split products in the blood are really elevated nearly without exception in the first 4 to 6 weeks after ceasing of hormonal contraception. Foremost after the first spontaneous menstrual bleeding they are at a normal level.

Basophils↗
PubMed1976

[Hormonal contraception--thromboembolic disorders and surgical risk (author's transl)].

Epidemiological, coagulational, hemodynamical, and morphological studies are critically analysed in this review. Our attitude towards the surgical operation risk under hormonal contraceptives is explained. For smaller operative procedures a break in hormonal contraception is not necessary. If greater operations are envisaged they have to be performed only 4 to 6 weeks after cessation of hormonal contraceptives, i.e., after the first spontaneous menstrual bleeding. Hints are given for the necessity of thromboembolic prophylaxis with heparin in unforseen greater operations without an interval free from pills or in additional risk factors.

Adult↗
PubMed1975

[Recent aspects of thrombogenesis and thrombosis prevention].

Proceeding from experimental and natural conditions the modern opinion concerning the importance of Virchow's triad for the development and prophylaxis of thrombosis is explained. As to the point change of the quality of blood the author enters the newer findings of the behaviour of heparinocytes, fibrinolytic proactivators and split products as well as other endogenous protective mechanisms. The dependence on age of the heparinocytes and thymocytes is compared and the possible common root of the thrombogenesis and the genesis of tumours is taken into consideration. The influence of sexual steroids, nutrition, the consumption of coffee, tea, cigarettes, alcohol, etc., influence of weather and light on the endogenous and medical prophylaxis of thrombosis is discussed.

Age Factors↗
PubMed1975

[Demonstration of fibrinolytic split products during administration of hormonal contraceptives].

During intake of four different hormonal contraceptives: Ovosiston (Mestranol 0,08 mg, Chlormadinone acetate 2 mg), Non Ovlon (Ethinylestradiol 0,05 mg, Norethindrone acetate 1 mg), Sequenz-Ovosiston and Deposiston (4th, 11th and 18th cycle day 1 mg Ethinylestradiolsulfonate, 25th cycle day 10 mg Norethindrone acetate) an increase of fibrinolytic split products in contrast to low values of the normal menstrual cycle is to be seen. While the values in the first two thirds of application of drugs undulate in the last third they are high in all four pills tested. It seems to be an interference of fibrinogenolysis by estrogens and secondary fibrinolysis after slight disseminated intravascular clotting by gestagens.

Adult↗
PubMed1975

[Potency determination of horse anti-human-lymphocyte serum (ALS) by means of the lymphocyte resistance test, a modification of Schroder's leukocyte resistance test].

The leukocyte resistance test of Schröder was used for the purpose of modifying the in vitro determination of cytotoxic potency of ALS during the course of immunization. In contrast to the original method, where the test was carried out with whole blood, the incubation was made with pure lymphocyte cell suspensions. The results obtained show that the extensive procedure of examination enables the cytotoxic effectiveness of antilymphocytic antibodies to be evaluated.

Animals↗
PubMed1975

[The question of thrombocyte substitution as a prophylactic measure in splenectomy for idiopathic thrombocytopenic purpura (ITP)].

The problem of intraoperative thrombocyte transfusion in splenectomy of patients with ITP is discussed. The indication for splenectomy cannot be equalized with that for intra-operative platelet substitution. Thrombocyte kinetic examinations with a concurrent determination of the thrombocyte turnover enable those patients to be recognized by their bleeding tendency who are particularly endangered by operations. The intraoperative platelet substitution should be limited to those patients with ITP whose turnover is markedly lowered as a manifestation of reduced thrombocytopoiesis. In these cases it is advisable to shift splenectomy to a later date.

Blood Platelets↗
PubMed1975

[Changes in heparinocytes during the administration of Depositon and Sequenz-Ovosiston].

During hormonal contraception with Deposiston (once a week pill) and with Sequenz-Ovosiston (14 days mestranol 0.1 mg, 7 days mestranol 0,08 mg and 2 mg chlormadinone acetate) doesn't take place a change of basophil granulocytes (heparinocytes) in blood. Under Deposiston the small elevation is somewhat lengthened, under Sequenz-Ovosiston the elevated phase is similar to those of the normal menstrual cycle. The smaller risk of thromboembolia under heparinocytopenia preventing contraceptives is discussed.

Agranulocytosis↗