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Biomedical subjects

G Godó

Publications and source records attributed to G Godó.

At least 19 recordsLinked to original sources
PubMed2000

[Significance of nuchal edema in fetuses of pregnant women under 35 years of age].

The aim of this study was to survey the connection between the fetal nuchal oedema and the increased risk of the aneuploidies. According to the prenatal care the thickness of the nuchal fold was measured on the 11-12th gestational week by 6.5 MHz transvaginal transducer (ATL-HDI and Hitachi EUB-450). Cases were underlined where the presence of nuchal oedema (> or = 3 mm) made the indication for chromosomal analysis among the 280 single pregnancies and fetal karyotyping was carried out. Nuchal oedema was observed in 72/280 cases of pregnant women under 35 years old and in 20/280 cases of that above 35 years old, the nuchal oedema was another indication beside the age. Abnormal karyotype was observed in 9/72 (12.5%) cases among the pregnant women under 35 years old and in 10/92 (10.87%) cases among the pregnancies with fetal nuchal oedema. It was also observed abnormal karyotype in 6/188 (3.19%) cases of pregnancies without nuchal oedema and in 16/280 (5.71%) cases of chromosomal analyses with or without nuchal oedema. This can be an effective method for screening the fetal aneuploidies and other fetal anomalies, both in the high risk and the normal pregnant population, especially in cases of pregnant women under 35 years old belonging to the normal genetical risk population.

Adolescent↗
PubMed1998

[Experience with gestodene-containing hormonal contraceptive].

An oral contraceptive containing gestodene (Minulet) was examined in collaborating with the Richter-Wyeth Pharmaceutical Factory. The authors present their experiences of monitoring of 591 cycles of a hundred women between 18 and 35 years of age. There were no pregnancy and severe side effects during that period. Irregular bleeding occurred in 17.5% of women in the beginning of the treatment, however it gradually decreased and ceased by the fifth cycle. Both the length and the quantity of the withdrawal bleeding decreased by the end of the sixth cycle. During the observation there was no amenorrhoea and the dysmenorrhoea presented a decreasing tendency, expressing in per cent of the cycles. Their own data support, that the oral contraceptives containing gestodene meet requirements of today's medical science, and beyond the low hormone content they also fulfil the next demands: reliable contraceptive effect, efficacy, excellent cycle control, good tolerability and limited side effects.

Contraceptives, Oral, Synthetic↗
PubMed1990

[Simultaneous occurrence of bilateral extrauterine pregnancy and ovarian hyperstimulation syndrome following artificial heterologous insemination (differential diagnostic difficulties)].

Simultaneous occurrence of bilateral extrauterine pregnancy and hyperstimulation syndrome of the ovary following artificial heterologous insemination, meaning difficulty in the differential diagnosis, is described. In connection with the case the protocol of induction of ovulation used regularly by the authors is presented and the necessary monitoring model is described. If the observation is suitable the emergency operation of a patient in bad physical condition can be avoided in the opinion of the authors. The close correlation between the hyperstimulation of the ovary and early-pregnancy as well as the favourable spontaneous healing disposition of the cystic alteration is highlighted. It is held important that a laparotomy performed in connection with acute abdominal symptoms should be conservative for the genitals--possibly even in case of extrauterine pregnancy--in order to maintain the chances for a later fertility.

Adult↗
PubMed1989

Ovulation induction with pulsatile administration of human menopausal gonadotropin.

Ovulation induction was performed by the pulsatile administration of subcutaneous human menopausal gonadotropin (hMG). Treatment was started with a daily dose of 75 IU hMG (in a 90% distribution), then it was increased to 150 IU depending on the oestradiol level of the plasma and on the result of folliculometry. Of 10 cycles treated ovulation was induced in 7 cases and two pregnancies occurred. In two cases, following a previous unsuccessful intramuscular hMG treatment, ovulation was induced. Hyperstimulation did not occur. The pulsatile s.c. administration of hMG seems to be an adequate ovulation-induction method in ovulatory disorders of hypothalamo-hypophyseal origin and is a good substitute for the missing, endogenous gonadotropin secretion of inadequate pace.

Adult↗
PubMed1988

Up-to-date surgical management of tubal infertility due to inflammations of the pelvis.

A total of 87 refertilization operations in the distal tubal segment are reported. Tubal obstructions developed following inflammations of the pelvis. Hysterosalpingography and laparoscopy were used to learn about the patients' anatomy and these served as bases for assessing the changes of pregnancy following recanalization. The interventions were made by applying up-to-date microtechnical methods and instruments. Among the causes of tubal infertility, the interruption of the first pregnancy showed a marked prevalence. The 20 pregnancies that ensued correspond to a success rate of 23%. Mature deliveries occurred in 17 cases. A considerable proportion of the pregnancies occurred within a year of the operation. The effectiveness is mainly influenced by adhesions in the pelvis and the characteristics of the distal tubal segment. The surgical solution is worth attempting when the expected chances are over 20%.

Adult↗
PubMed1986

Plasma cortisol, prolactin and thyroxine levels related to midazolam anaesthesia.

Changes of plasma cortisol, prolactin and thyroxine levels as a result of surgical stress were examined in 11 patients undergoing abdominal hysterectomy. General anaesthesia was induced with the new benzodiazepine derivative midazolam (0.25 +/- 0.04 mg/kg) and maintained by nitrous oxide in oxygen. Plasma cortisol and thyroxine levels slightly decreased at the induction of anaesthesia and the beginning of surgery, while the prolactin level increased. By the end of surgery the cortisol and prolactin concentrations increased significantly, although the thyroxine level had barely changed. The highest hormone values were observed a few hours after the operation, but on the next morning hormone levels approached the normal range. On the basis of these results anaesthesia induction with midazolam can be said to have favourably affected the unwanted degree of hormonal changes related to surgery.

Adult↗
PubMed1986

Pregnancy, delivery and lactation in hyperprolactinaemic women.

A report is given of 87 pregnancies in hyperprolactinaemic women treated with bromocriptine. The high prolactin level in 11 cases was caused by hypophyseal adenoma. If the plasma prolactin level exceeded 5000 mU/l during pregnancy, bromocriptine was administered until delivery. If the initial prolactin value was over 1000 mU/l, the prolactin level was measured during pregnancy, delivery and the lactational period. After weaning, the prolactin level was again elevated in the majority of cases. During pregnancy, delivery and lactation, complications which differed significantly from the usual were not observed, pregnancy and nursing took place normally. Breast feeding was not contraindicated in any of the cases. Among the newborns, adaptation disturbances and congenital malformations, showed the usual frequency. In the authors' opinion pregnancies which occur during the treatment of hyperprolactinaemic patients need increased care. Complications during pregnancy, delivery and nursing period were not more frequently observed either in the mother or the newborn. The hyperprolactinaemic syndrome did not deteriorate during gestation and lactation, but its normalization can not be expected.

Bromocriptine↗
PubMed1984

Hyperprolactinaemia and female infertility.

The clinical use of bromocriptine was investigated in 50 hyper- and 30 normoprolactinaemic women attending an infertility clinic and presenting with anovulatory cycles, oligomenorrhoea or amenorrhoea and the complaint that they had failed to become pregnant. The results confirmed that bromocriptine is effective in the treatment of hyperprolactinaemic states. Bromocriptine supresses prolactin secretion irrespective of the underlying pathologic process. Hyperprolactinaemia in humans is frequently associated with anovulation. Serum prolactin values showed no close correlation with the degree of menstrual abnormalities or galactorrhoea. Basal FSH and LH levels and the gonadotropin response to LH-RH were essentially normal in hyperprolactinaemia. Circulating E2 levels were largely subnormal suggesting an inhibitory effect of prolactin on ovarian E2 production. Prolactin levels over 100 ng/ml are suggestive of pituitary adenoma.

Adolescent↗