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Biomedical subjects

G Godó

Publications and source records attributed to G Godó.

30 records · Page 2Linked to original sources

[Prolactin-producing hypophyseal adenomas].

It is a report about the diagnostic and the therapy of 10 women with a hyperprolactinemia caused by microadenomas of the hypophysis. The diagnose was made by reason of clinical symptomatology and hormonal and neuroradiological investigations. In six cases the tumor was removed by transsphenoidal route. One women does not give her consent to the microsurgical operation. In three patients the operation seemed not to be indicated absolutely. We gave them a longlasting therapy with bromocriptine. After operation galactorrhea decreased and we found ovulatory cycles in any case. It was concluded, that the results may be better, if the patients are dealt with bromocriptine for a long time, so abolishing the still existing complaints.

Adenoma↗

Response of the cervical factor to combined treatment with clomiphene and ethinyl-oestradiol.

Combined clomiphene + ethinyl-oestradiol therapy was applied to 103 women with functional infertility. Ovulatory responses were obtained with clomiphene in a number of cases, but no pregnancy ensued. Ethinyl-oestradiol was then administered in low doses together with clomiphene over 3 cycles until the day before the expected date of ovulation. This resulted in a further increase in the number of ovulatory cycles, and one-third of the women had become pregnant. Comparing the two types of treatment on the basis of quality, quantity and sperm-penetration of the cervical mucus, low doses of oestradiol were found to affect these parameters favourably. If the treatment is unsuccessful, i.e. if the parameters of mucus or of the conditions of penetration fail to respond, further investigations are required to find out whether a permanent damage to the cervical epithelium or some penetration disorder of immunological origin is responsible for the infertility.

Adult↗

[Results of treatment with bromoergocryptine in functional infertility caused by corpus luteum insufficiency].

Eighty women were treated with bromocryptine (Parlodel, Sandoz). They were infertile in consequence of luteal insufficiency. The luteal function got normalized i 83.6% of the patients, and 31.3% of them became pregnant. The dopaminergic treatment was most successful in the case of those hyperprolactinemic women, who were infertile due to luteal dysfunction only. The treatment was less effective in case of normoprolactinaemia, and in case of luteal dysfunction with other reasons of infertility, too.

Adult↗

[Laparoscopy and hysterosalpingography in sterility examination (author's transl)].

Hysterosalpingographic and laparoscopic findings were recorded from 90 patients and compared. They were identical in 71 per cent of all cases, but in some of the cases additional findings proved recordable from laparoscopy. The point is made by the authors that laparoscopy should in any case be preceded by hysterosalpingography, since the latter is a comparatively uninvolved method which even may have therapeutic effects. Laparoscopy is indicated particularly in pathological cases or in cases of uncertain diagnosis or prior to surgery for salpingoplasty. This is the only diagnostic method by which accurate assessment is possible of the organs in the minor pelvis and of tubal function. Today, laparoscopy may be considered a safe no-risk procedure, if all necessary conditions are provided, but adequate equipment actually is available only in larger institutions at present.

Adolescent↗

Bromocryptine therapy in luteal insufficiency.

Fifteen cases of female infertility, probably connected with luteal insufficiency, are reported. This abnormality was found to be fairly common in hyperprolactinaemic and clomiphene-treated normoprolactinaemic women with galactorrhoea. Bromocryptine reduces the prolactin-level, prolongs the luteal phase and increases the secretion of progesterone. According to the observations thus far reported, some optimum prolactin concentration seems to be desirable for an adequate luteal function. In the case of luteal insufficiency, estimation of the prolactin and progesterone level in the luteal phase is advocated. The basal temperature curve the hyperthermic phase to be followed up before and after treatment allows.

Adult↗

[Treatment of hyperprolactinemic conditions with bromoergocryptine].

Ten hyperprolactinemic patients were treated by a daily dose of 5 mg bromergocryptine (Parlodel, Sandoz). The prolactine concentration in the peripherial blood showed a fast declind and after two months the patients were relieved from the symptoms (galactorrhea, amenorrhea). As side-effects of the compound headache and nausea were noted.

Adult↗