Goya's living skeleton.
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Biomedical subjects
Publications and source records attributed to G Hooper.
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66 patients with congenital or acquired amputations of the hand have been studied after fitting partial or complete silicone hand prostheses which can be manufactured at relatively low cost. Most patients used their prostheses on social occasions only and all but four expressed satisfaction with them.
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We report eight patients who sustained simultaneous dislocations of two joints in a digit. The little finger was involved in five patients.
We report two patients who presented with large nail retention cysts, 17 and 22 years after digital reconstructions using pedicled flaps.
We report an adult patient with congenital dysplasia of the ring finger who required a corrective osteotomy for an angulatory metacarpal deformity.
We review 17 patients who had 21 amputations of the little finger. Transmetacarpal amputations gave satisfactory results in older patients, but in young patients loss of breadth of the palm caused significant disability. Disarticulation through the metacarpophalangeal joint is recommended in younger patients.
This is a case report of a hemangiopericytoma located within the median nerve at the wrist in a 79-year-old man. The tumor was removed without loss of function.
Furazolidone and nitrofurazone showed in vitro activity against amastigotes of Leishmania donovani, L. enriettii and L. major in macrophages, at concentrations which were also toxic to the macrophages. A low grade of activity was observed against L. donovani infections in BALB/c mice by furazolidone but not with nitrofurazone. Nitrofurazone, in two concentrations, was not active when applied to the lesions of cutaneous leishmaniasis due to L. enriettii (guinea-pig infection) or L. major strain P (BALB/c mouse infection). After systemic administration to BALB/c mice infected with L. major strain JISH 252 clone 1, low-grade activity was observed at the highest level tested.
Acute traumatic dislocation of the trapezio-metacarpal joint is not invariably associated with instability of the joint after reduction and the injury should not be considered simply as a "Bennett's fracture without a fracture".
We report a woman patient with Ehlers-Danlos Syndrome who presented with trapezio-metacarpal subluxation and whose hands exhibited several other skeletal features of Ehlers-Danlos Syndrome, including acro-osteolysis.
Radioactive microspheres were injected into the tibial nutrient arteries of dogs. The validity of their use to measure bone blood flow was tested by examining their concentration in femoral venous blood. Non-entrapment in the tibia was considerable in two animals following rather prolonged alternate periods of perfusion and ischaemia. When such treatment was minimised, non-entrapment was small, showing that in this respect microspheres provide a valid means of measuring bone blood flow.
The distribution of blood flow to segments of the leg bones of anaesthetised dogs was studied using radioactive microspheres injected into the heart or the tibial nutrient artery. Following central injection, repeated measurements after an interval showed no change of pattern of distribution. The effects of ligation of the tibial nutrient artery during this interval suggested that 30% of the blood flow to the tibia is normally via this vessel, which predominantly supplies the diaphysis. This deduction differed from that derived from the injection of microspheres during perfusion through a tibial nutrient artery cannula, when half the flow reached the epiphyses. This proportion decreased and the flow to the diaphyseal marrow increased after alternate periods of perfusion and ischaemia, demonstrating the labile nature of bone blood flow distribution.
This report describes entrapment of the ulnar nerve in a greenstick fracture of the ulna, with complete recovery of function after freeing the nerve from bone.