[Consciousness disorder and spasm: nephrosclerosis (problems of dialysis therapy)].
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Biomedical subjects
Publications and source records attributed to G Inoue.
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The effect of protein deficiency on the rate of loss of radioactivity from body constituents was studied in adult rats administered 14C-Chlorella protein hydrolysate or 14C-lysine. Rats were kept on a protein-free diet for 3 weeks and then injected with labelled amino acids and fed on a protein-free diet for 3 more days to allow 14C deposition in tissues. Then they were given experimental diets (protein-free diet, 1% and 10% wheat gluten diets pair-fed with the protein-free diet, and 10% wheat gluten diet ad libitum) for 7 days and sacrificed. The rates of loss of radioactivity from tissue proteins became low in general with the extent of protein deficiency. This increased capacity of tissues to retain 14C-amino acids may result from higher efficiency of protein utilization in protein deficiency. The reutilization of free amino acids and the rate of catabolism of tissue proteins are discussed on the basis of the results. The half-life of muscle protein was too long to observe the effects of experimental diets given for 7 days on the rate of loss of radioactivity.
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Twenty cases of microgeodic disease affecting the hands or feet of children are presented, and the relevant literature is reviewed. Clinical features include chilblain-like appearance and tenderness of the involved digits. Radiographically patchy osteoporosis of the diaphysis and/or sclerosis of the diaphysis and rarefaction of the metaphysis with cortical erosion is evident, often accompanied by subperiosteal new bone formation. Characteristically, this condition occurs in winter and resolves spontaneously within 6 months clinically and radiographically. This lesion appears to result from vascular insufficiency of the hands and feet causing bone infarction secondary to intense vasospasm precipitated by cold.
This paper has described three cases of simultaneous dorsal dislocation of both interphalangeal joints of a finger. Although two of three patients had minimal limitation of the active range of motion of the PIP and DIP joint, none had complaints of functional disability in their finger.