Methylscopolamine and conditioned location avoidance.
On alternate days, rats were confined to one side of a shuttlebox following IP administration of saline and to the other following the peripherally-acting muscarinic antagonist, methylscopolamine (1.2 mg/kg). They later avoided the side associated with the drug effect. By duplicating an earlier finding with centrally- and peripherally-acting scopolamine, this result identified aversive peripheral actions of the two drugs as mainly responsible for the effects observed.
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