Fine needle aspiration cytology of well-differentiated fetal adenocarcinoma (endodermal tumor) of the lung.
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Biomedical subjects
Publications and source records attributed to G K Nguyen.
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Minute fresh tissue fragments from 20 pituitary adenomas and 18 oligodendrogliomas were crushed between two glass slides and stained with hematoxylin and eosin for cytologic examination. These two tumor types displayed distinctive cytologic features that may permit their correct identification. Pituitary adenomas were characterized by single and clustered tumor cells with monomorphic, round or vesicular nuclei that were commonly denuded of cytoplasm. Rare well-preserved tumor cells showed well- or ill-defined, variable and granular cytoplasm. Oligodendrogliomas showed cells with monomorphic or slightly pleomorphic nuclei and scant, fibrillary, wispy cytoplasm, commonly arranged in clusters or around circular and empty spaces.
A 17-year-old boy presented with severe chest pain which partially subsided on anti-inflammatory medication. Five week later he was admitted with fully developed cardiac tamponade. Within five days surgical exploration revealed an nonresectable right atrial tumour. Management of angiosarcoma of the heart is discussed.
Transabdominal fine needle aspiration biopsy of a solitary space-occupying lesion in the liver produced smears containing irregular bundles of smooth muscle cells with granular or fibrillary cytoplasm and slightly pleomorphic nuclei. In a few bundles, aggregates of mature fat cells were present, which is characteristic for an angiomyolipoma. Histologic examination of the resected mass showed it to be a solitary angiomyolipoma of the liver. The diagnosis was further confirmed by immunohistochemical and electron microscopic studies.
Fifty-six brain tumors of neuroectodermal origin were sampled by computed tomographic stereotactic needle biopsy. Crush preparations prepared from tiny tissue fragments displayed distinctive cytologic characteristics of different tumor types in 77% of the cases. The adjunctival value of crush preparations to frozen section diagnosis is discussed, and the cytologic features of different types of neuroectodermal brain tumors in crush preparations are illustrated.
Benign clear cell tumor (BCCT) of the lung is an uncommon neoplasm, with about 24 cases reported in the literature. A fine needle aspirate from a histologically and ultrastructurally confirmed BCCT of the lung contained large irregular clusters of polygonal and spindle-shaped benign-appearing cells with vacuolated, granular, periodic-acid-Schiff-positive cytoplasm. Cytologic study of the aspirate suggested a pseudoinflammatory tumor; however, a metastatic renal cell tumor or a primary clear cell or mesenchymal tumor could not be excluded. The histologic, ultrastructural and cytochemical findings are also presented, and the cytologic differential diagnosis of this neoplasm is briefly discussed.
The cytologic findings in two adenoid cystic and three mucoepidermoid carcinomas of the bronchial tree are reported. In one case of adenoid cystic carcinoma, the diagnosis was made on a fragment of tumor tissue exfoliated in the patient's sputum. In the other case, brushing and aspirated materials yielded large clusters of small cells arranged around cystlike spaces containing globular basophilic mucuslike material. Fine needle aspirates from the two low-grade mucoepidermoid carcinomas showed clusters of malignant squamous cells containing mucus-secreting cells. The high-grade mucoepidermoid cancer yielded malignant squamous and glandular cells in aspirates.
Twenty-three meningiomas and 14 neurilemomas were studied by frozen section and crush-preparations techniques. These two types of tumors displayed distinctive cytologic pictures, permitting a correct identification in all cases. Six cases of deeply seated and unusually located meningioma and neurilemoma with equivocal or erroneous frozen section diagnoses were correctly diagnosed cytologically in the crush preparations.
Sixteen cases of metastatic renal cell carcinoma diagnosed by fine needle aspiration biopsy were reviewed. Polygonal malignant epithelial cells present in sheets with loose or strong cellular cohesiveness and granular, vacuolated or filmy cytoplasm were the characteristic findings of this type of tumor.
Aspirated material from two cases of histologically and ultrastructurally confirmed adenocarcinoid tumor of the lung was evaluated. In one case, columnar and cuboidal cells with ill-defined cytoplasm and round or oval nuclei were seen in large sheets and syncytiumlike clusters with focal glandular arrangement. In the other case, spindle-shaped and columnar cells with ovoid nuclei and ill-defined cytoplasm were seen singly and in loose clusters. Fragments of tumor epithelium with nuclei arranged in pseudo-stratified pattern were noted. Staining of tumor cells by the Grimelius technique demonstrated numerous intracytoplasmic brown-black granules. The cytologic differential diagnosis between adenocarcinoid tumor and other primary and metastatic adenocarcinomas of the lung is briefly discussed.
The aspiration cytology of two cases of solitary schwannoma is documented. The first tumor was retroperitoneal and cystic; the aspirated fluid showed single, regular, spindle-shaped cells with cigar-shaped nuclei and scanty wavy cytoplasm in addition to lymphocytes and foamy histiocytes. The second tumor was solid and peripheral; its aspiration smears revealed spindle-shaped cells with cigar-shaped nuclei present singly or in clusters showing nuclei in a palisading pattern.
The cytologic appearance of cells in fine needle aspiration biopsies of two cases of well-differentiated renal oncocytoma (grade 1) and one case of moderately well differentiated renal oncocytoma (grade 2) is presented. In grade 1 renal oncocytoma, the tumor cells were seen mainly singly or in small clusters; they were round or polygonal, with abundant granular and eosinophilic cytoplasm and small, regular, round, hyperchromatic nuclei. Aspirated cells from the grade 2 renal oncocytoma were seen mainly in large sheets. These cells were polygonal, with eosinophilic, granular cytoplasm and slightly irregular vesicular nuclei with prominent nucleoli.
Transabdominal fine needle aspiration biopsy of a metastatic myxoid chondrosarcoma in retroperitoneal spaces revealed amorphous mucoid material containing clusters of chondroblasts with round hyperchromatic nuclei and scanty cytoplasm, pleomorphic mesenchymal cells with round nuclei and vacuolated cytoplasm and groups of immature cartilaginous cells with single or double nuclei and fibrillar or filmy cytoplasm. The cytologic differential diagnosis between myxoid chondrosarcoma and other myxomatous tumors of bone and soft tissue is discussed.
A case of primary angiosarcoma arising from the pulmonary artery of the left upper lobe is documented. Clinically, the tumor presented as an asymptomatic solitary lung mass. Exfoliated tumor cells in bronchial washing material occurred singly, in irregular clusters and in sheets with focal glandlike arrangement. They showed ill-defined, pale cytoplasm and fairly regular round-to-oval nuclei with irregular chromatin patterns.
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Report is made of a fine needle aspiration biopsy of a clinically occult right adrenal pheochromocytoma that manifested itself as a pyrexia of unknown origin in a 38-year-old male. The argyrophil stain on aspirated tumor cells was found to be helpful in making the diagnosis. The cytologic differential diagnosis is briefly discussed.
The cytopathologic findings of a fine needle aspiration biopsy of pulmonary metastasis of a malignant fibrous histiocytoma, myxoid variant, are documented. Isolated and irregular loose clusters or bundles of spindle cells and pleomorphic multinucleated giant cells were found. No signet-ring lipoblastlike cells were identified. The cytologic findings were similar to the histology of the primary tumor removed from the patient's leg 18 months previously.