Biomedical subjects
Publications and source records attributed to G K Nguyen.
A 57-year-old woman developed pulmonary sarcoidosis during therapy with interferon beta for advanced renal cell carcinoma metastatic to mediastinal lymph nodes. The possible role of interferon beta in the pathogenesis of sarcoidosis in this patient is discussed.
Aspirate from a secretory carcinoma of the breast showed malignant epithelial cells present singly or in large sheets with strong cellular cohesiveness. Tumor cells displayed ill-defined, granular, or vacuolated cytoplasm. Intracytoplasmic globular material was periodic acid-Schiff positive and resistant to prior diastase digestion. The cytologic differential diagnosis with other breast cancers is briefly discussed.
A case of ultrastructurally confirmed myoepithelioma of the breast studied by fine-needle aspiration biopsy is reported. Aspirated tumor cells were spindle-shaped with well-defined cytoplasm and oval nuclei showing no remarkable nuclear pleomorphism. They were seen mainly in irregular bundles with strong cellular cohesiveness. Their cytoplasm contained S-100 protein demonstrated by the peroxidase antiperoxidase staining technique.
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Aspiration biopsy of four primary endocrine tumors of the pancreas showed single and large sheets of tumor cells. Tumor cells were polygonal in shape with ill-defined, filmy or granular cytoplasm and regular round nuclei containing a finely granular chromatin pattern and inconspicuous or prominent nucleoli. Focal gland-like arrangement was seen in several sheets of tumor cells. Aspirate from liver metastases of an endocrine tumor of the pancreas showed single and clustered oval cells with granular cytoplasm and eccentrically located round and hyperchromatic nuclei. Smears prepared from aspirates of three fibrotic pancreata containing nodules of hyperplastic endocrine cells showed smaller fragments of endocrine-cell epithelium with focal gland-like arrangement. Individual hyperplastic endocrine cells displayed granular, filmy, and ill-defined cytoplasm and round to oval hyperchromatic nuclei showing a finely granular chromatin pattern. Nuclear pleomorphism was noted in some cell groups.
Aspiration biopsy from metastatic tumors in two cases of endometrial stromal sarcoma and one case of endometrial adenosarcoma revealed malignant endometrial stromal cells with ill-defined cytoplasm and round or oval hyperchromatic nuclei showing irregular chromatin clumping and conspicuous nucleoli. They were seen mainly in clusters. Aspirate from a metastatic tumor of a mixed mesodermal tumor arising from the omentum showed similar malignant endometrial stroma cells, irregular tight clusters of malignant glandular cells having scanty but well-defined cytoplasm and vesicular nuclei with conspicuous nucleoli, and fragments of atypical smooth muscle tissue. The diagnostic malignant endometrial stromal cells in those reported cases did not display any distinctive cellular features permitting their cytologic identification. They were difficult to differentiate from those of other types of sarcoma. In a clinical setting, with a known primary endometrial stromal sarcoma or mixed mesodermal tumor, however, a cytodiagnosis of its metastases may be suggested when malignant endometrial stromal-cell-like cells are seen in aspirated material, oviating an open-tissue biopsy.
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A previously healthy, 59-year-old man suddenly developed epigastric pain followed by jaundice. Extensive clinical investigations suggested that the patient had a sclerosing cholangitis. At laparotomy, the extrahepatic bile ducts near their confluence were found markedly thickened. A biopsy specimen was obtained from the common bile duct. It showed a diffuse lymphohistiocytic infiltration, suggesting a lymphomatous infiltration. No evidence of a lymphoma was found in the abdominal cavity or in the retroperitoneal spaces. The clinical consensus at that time was that the patient had a primary sclerosing cholangitis involving the extrahepatic bile ducts. Biliary obstruction was released. Five months later, the patient developed a disseminated lymphoma, lymphohistiocytic, diffuse in type.
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Squash-smears of tissue from a chondroid chordoma arising from the skull base of a 26-year-old white man showed numerous single and clustered physaliferous cells with multiple intracytoplasmic vacuoles, and atypical cartilaginous cells in an amorphous myxoid background.
Samples obtained by fine-needle biopsy of two benign and one malignant hemangiopericytoma revealed tumor cells with round, oval, or spindle-shaped nuclei, with variable and ill-defined filmy cytoplasm. The nuclei had a finely granular chromatin pattern with or without inconspicuous nucleoli. They were seen singly or in loose or dense cellular clusters. Focal gland-like arrangement of tumor cells was noted in some cellular clusters. Benign endothelial cells were seen among tumor cells and were not cohesive to the latter. The benign and malignant nature of hemangiopericytoma cannot be predicted by examination of the cells present in the aspirates. Also, a specific diagnosis of hemangiopericytoma could not be made on cytologic basis alone as cells of hemangiopericytoma were difficult to differentiate from those of other spindle-cell mesenchymal tumors.
Two cases of clear-cell sarcoma arising from the leg with widespread metastasis were reported. Exfoliated tumor cells in pleural effusions were round, oval, and slightly pleomorphic. They were seen singly or in clusters of variable size with marked cellular cohesiveness and molding. Their cytoplasm was well-defined, clear, or finely granular, and contained S-100 protein and periodic acid-Schiff positive material that was digestible by diastase. Tumor-cell nuclei were round and hyperchromatic with irregular chromatin clumping, and showed conspicuous nucleoli.
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