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Biomedical subjects

G K Shlygin

Publications and source records attributed to G K Shlygin.

At least 19 recordsLinked to original sources
PubMed1999

[Thermal skin reaction to food intake and its changes in certain forms of obesity].

The authors review data on recently discovered temperature response of deep skin layers to the meal. The reaction is of a reflex nature and is one of the mechanisms regulating heat exchange in the body. In healthy people this reaction is weak. In alimentary obesity, it becomes much stronger, probably due to impaired heat exchange because of accumulated fat. In obesity related to diencephalic syndrome skin reaction is similar to control. In this obesity, pituitory seems to lose ability to regulate circulation in the blood. The above reaction can be used as a test differentiating the two forms of obesity.

Body Temperature↗
PubMed1995

[Thermal reaction of subcutaneous tissue to food intake in patients with obesity].

Investigating the temperature of deep layers of skin and in the main of subcutaneous tissue in patients with obesity we found the close connection between changes of this temperature and food intake. In patients who are in postabsorptive period the intake of the small portion of test food (220 kcal) induces in 3-4 min a marked increase of the subcutaneous tissue temperature (often by 1.0-1.5 degrees C in comparison with the initial level). Further the temperature still rises some what and then keeps at increased level for 30-45 min. At the end of the treatment course of patients in the clinic (and the body weight loss by 10-14 kg) these changes of the temperature become much less intensive or do not quite manifest. The above thermic reaction is developed apparently as a result of the dilatation of blood vessels of the skin and filling the venous plexus with the arterial blood. Probably in depends upon the regulatory activity of hypothalamus which is directed on an increase of heat loss into environment.

Body Temperature↗
PubMed1991

[Potentiating effect of sodium glutamate on gastric secretion and its possible use as a clinical test].

The authors report a potentiating effect of sodium glutamate on gastric secretion in subjects free of gastrointestinal diseases. Similar effect has been discovered in dogs. In subjects with gastric hyposecretion (chronic gastritis, functional regulatory disturbances) sodium glutamate combined with pentagastrin is a helpful tool in overall evaluation of gastric secretion. In achlorhydria is can be used for determination of a residual capacity of the stomach to secrete the hydrochloric acid in failure of humoral stimulators.

Achlorhydria↗
PubMed1991

[Radiothermometric research of tissues during the initial reflex period of the specific dynamic action of food].

Radiothermometry-aided investigations have shown that the initial period of specific dynamic food action (SDFA) in man is characterized by a distinct rise of temperature of tissues of some organs. A rise of temperature in liver, intestinal and brown fatty tissues (by 0.5-0.9 degree C) is noted 3-10 min. after taking exploratory food (220 kcal). As has been shown before, a considerable rise of oxygen, consumed by the body, is noted. The results obtained reaffirm the existence of the initial reflectory period of SDFA in man and suggest that the liver, intestine and brown fatty tissue play the role of executive organs in this period.

Adult↗
PubMed1989

[The role of the gastrointestinal tract in metabolism: the confirmation and further development of the ideas of I. P. Razenkov].

According to the conception proposed by I. P. Razenkov, in addition to digestion proper, the gastro-intestinal tract is responsible for processes directly supporting metabolism. This conception has provided the basis for the modern concept of the circulation of a great amount of endogenous nutrients, proteins in particular, between blood and the digestive tract, which enriches and corrects the composition of exogenous proteins. Hepato-intestinal circulation of substances is a similar process too. Studies of active adaptations of the digestive glands to qualitative changes in nutrition have provided another evidence in its favor. There are several pathways to connect gastrointestinal tract with metabolism, according to the data accumulated up to now. In addition to the above-mentioned ones, they include gastro intestinal participation in hormonal control metabolism, excretory processes, biochemical activity of normal intestinal flora, etc. A rapidly progressing area of experimental and clinical research, dealing with the role of dietary fibres in nutrition is directly rooted in I. P. Razenkov's views and perfectly confirms their validity.

Animals↗
PubMed1988

[Effects of glutamic acid and glutathione on the secretory function of the stomach].

Experiments on dogs with Pavlov isolated pouches and gastric fistulas have shown that the ingested solution of MSG produces a potentiating effect on maximal gastric secretion caused by pentagastrin. This effect is apparently connected with the formation of glutathione in intestine. The glutathione concentration in blood after the intake of MSG is significantly elevated. It has been established that reduced glutathione administered in blood produced the similar potentiating effect on gastric secretion caused by pentagastrin.

Animals↗
PubMed1979

[Effect of parenterally administered amino acids and protein hydrolysate on the electrical activity of brain structures].

Glycin, glutamic acid or casein hydrolysate induced high frequency and high voltage electrical waves in the brain-stem RF and often in the lateral hypothalamic nucleus and cortex. These changes were more obvious during feeding of the dogs. Sham feeding and parenteral administration of glucose or 0.9% solution of NaCl evoked responses different from the above ones. Gastric secretion stimulated by i.v. administration of nitrous substances by food was not directly related to the above responses either. The impulses responsible for the secretion seem to arise at another level of the brain.

Amino Acids↗
PubMed1979

The effect of some N solutions for parenteral nutrition on gastric and pancreatic secretion.

In patients without pancreatic disease Aminofusin L forte infused for 1 h did not stimulate gastric or pancreatic secretion. On the other hand, infusion of casein by hydrolysate led to a significant increase in the concentration and total output of HCl. 4 h intravenous infusion of Aminofusin L forte caused a transient but significant rise of the bicarbonate concentration, amylase activity and above all trypsin activity and output. The results show that N solutions used for parenteral protein nutrition influence in a different way both gastric and pancreatic secretion.

Amino Acids↗
PubMed1975

[The mechanism of action of parenterally administered protein hydrolysates on the exocrine activity of the pancreas].

In dogs with fistulae of the stomach and the pancreatic duct as well as in dogs with artificially made partition between the stomach and the duodenum, effect of protein hydrolysates administered into the blood, on the pancreas secretion, was shown to manifest itself only in conditions of unopposed transition of the stomach acid contents into the duodenum. In the mechanism of protein hydrolysates action on the pancreas secretion, the major part is played by their ability to stimulate the stomach secretion and the transition of the acid content into the duodenum. Under the influence of the acid contents, release of the secretin occurs in the duodenum which induces the secretion of the pancreatic juice.

Amylases↗