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Biomedical subjects

G K Shlygin

Publications and source records attributed to G K Shlygin.

At least 37 records · Page 2Linked to original sources
PubMedDate not supplied

[Inhibitory effect of parenterally administered dicarboxylic amino acids on gastric secretion].

Tests conducted on dogs established that glutaminic and aspargic acids introduced into the blood by the drip method call forth inhibition of the gastric secretion stimulated by other amino acids (alanine, glycine, proline). The dicarboxylic amino acids inhibit also the reflex phase of the gastric secretion provoked by injection of histamine. It is only against the background of a repeated introduction of histamine for many hours that they produce a sharply marked inhibitory effect. This manifests itself chiefly in dogs with denervated isolated pouches, while with intact innervation of gastric glands this effect is very poorly pronounced. Introduction of beta-adrenolytic-obsidan is attended by a drastic reduction of this effect.

Animals↗
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[The use of monosodium glutamate in the combined therapy of patients with atrophic gastritis].

Monosodium glutamate (MSG) taken per os has been found to stimulate gastric secretion provoked by pentagastrin. MSG gave rise to a marked elevation of endogenic gastrin levels both in experimental animals and atrophic gastritis patients. Thirty-six patients with secretory gastric insufficiency received MSG as an additive to their food during combined therapy of their disease. The preparation proved to be well-tolerated, good stimulant of gastric secretion, efficient in digestion improvement. MSG is recommended as an adjuvant in combined therapy of atrophic gastritis.

Administration, Oral↗
PubMedDate not supplied

[Inhibiting action of glycomacropeptide on stomach secretion induced by various humoral stimulants].

Tests staged on dogs demonstrated the action of GMP to differ depending upon the nature of the gastric secretion stimulant actually used. The inhibition of the gastric juice secretion occurring against the background of multiple introduction of histamine or gastrin tetrapeptide amide was quite spectacular: the secretion dropped down to zero and the action was more prolonged than following administration of pentagastrin with which the secretion was not inhibited to such a sharp degree and the effect of GMP was less protracted. The mechanism of the GMP action of the gastric secretion and the causes of described differences require further investigations.

Animals↗
PubMedDate not supplied

[Reflex nature of the initial component of thermogenesis].

In experiments on dogs with sham feeding it has been shown that the initial component of thermogenesis induced by food is of reflectory nature. During sham feeding 100 g of meat after 10-15 min induced 1.2-2-fold increase of oxygen consumption as compared to the initial value. Other food products (bread, butter, glucose solution) in the same time interval produce a slightly lower but always distinct effect. Even aspartam (28 mg in 50 ml of water) induces a manifest increase of oxygen consumption. This effect is completely eliminated by atropine. alpha- and beta-adrenoblockers (combined phentolamine and propranolol hydrochloride) lead to a sharp decrease in the intensity and duration of the effect. It has been concluded that both cholinergic and adrenergic nervous routes participate in this reflectory action. A suggestion has been made that the importance of this reflex lies in the anticipating stimulation of certain metabolic processes associated with impending assimilation of the ++consumed food.

Adrenergic Fibers↗
PubMedDate not supplied

[Pancreatic exocrine secretion to the introduction into the blood of amino acid mixtures of varying composition].

Tests conducted on dogs with a fistula of the pancreatic duct evidenced that various amino acids mixtures containing all the essential amino acids and differing mainly in the replaceable nitrogen dissimilarly act on the external secretion of the pancreas after their introduction into the blood. The most intensive secretion produces a mixture in which the replaceable nitrogen is represented by glycine alone. The mixture, one of its constituent is one of the dicarboxylic acids (glutamic) very poorly stimulates this function. At the same time, the action of all the studied amino acids mixtures is less pronounced than is the effect of the caseine hydrolysate. The commercial agent aminofusin L-600, containing all the essential amino acids with addition of polyols (xylitol and sorbitol) with no dicarboxylic amino acids in its composition, produces an intensive pancreatic secretion close to that caused by the caseine hydrolysate.

Amino Acids↗
PubMedDate not supplied

[Glutathione participation in regulating the secretory function of the stomach].

In experiments on dogs with Pavlov's pouches it was shown that glutathione infusion into the blood produced a highly pronounced stimulating effect on the gastric secretion induced by pentagastrin. Endogenous glutathione produced similar effect. It was found that intake as a drink of mono-sodium glutamate led to a significant increase of glutathione concentration in the dogs' blood, that was, probably, the result of its intensified production in the intestinal wall and passing into the blood. The growth of glutathione concentration in the blood coincided with its stimulating effect on the gastric secretion. Glutathione administered separately into the blood, or intake of glutathione without pentagastrin did not produce stimulating effect on gastric secretion. The data presented have evidenced that glutathione, besides its known functions, plays a role of the factor engaged in the regulation of gastric secretion.

Animals↗
PubMedDate not supplied

[Localization of the primary action of amino acids leading to the stimulation of gastric secretion].

An attempt has been made to specify whether the stimulant action of amino acids on gastric secretion is related to their direct effect on the structures of the central nervous system or to the influence on certain peripheral receptor formations followed by information transmission to the nervous centres. Acute experiments on dogs were performed to compare the effect of amino acids injected to the carotid artery and to the peripheral vein. It was established that amino acids injected to the carotid artery produced a more rapidly developing and more pronounced secretory reaction of the gastric glands than amino acids injected to the peripheral vein. This fact may strongly indicate that the above effect of amino acids is linked with their direct action on brain structures.

Amino Acids↗
PubMedDate not supplied

[Effect of a 10-day partial parenteral feeding on gastric secretion].

Investigations conducted on dogs subjected to a lengthy (10 days) parenteral introduction of the caseine hydrolysate ascertained an intensification of gastric secretion and an increase of total proteinases in the juice in the course of the experiment, reaching its peak on the 8-9th day. A study of the juice secretion in response to the food stimulant showed that this becomes more intensive during the first phase of the gastric secretion, which points to the importance of the nervous factor in the action of nitrogenous substances on the stomach.

Animals↗
PubMedDate not supplied

[Heterogeneity of the kappa-casein glycomacropeptide and physiological activity of its fractions].

A number of fractions with differing intensity of the inhibitory action on the gastric secretion were obtained by gel filtration in a column with biogels P-30 and P-2 of cappa-casein glycomacropeptide. A low-molecular fraction displays the greatest capacity for inhibiting gastric secretion. Desialism, heating and partial hydrolysis of glycomacropeptide with pepsin, trypsin and chemotrypsin used separately have no effect on its inhibitory activity. The resulting data suggest that the inhibitory action of glycomacropeptide is caused by a certain part rather than by entire molecule.

Animals↗