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Biomedical subjects

G K Zoloev

Publications and source records attributed to G K Zoloev.

At least 19 recordsLinked to original sources
PubMed2003

[Surgical treatment policy during motor rehabilitation of patients with a single ischemic lower extremity].

Altogether 218 patients suffering from obliterating arterial diseases with unilateral postamputation defects (PAD) of the lower extremities and 13 patients with bilateral PAD were examined. A study was made of the data pertaining to the age, motivation for rehabilitation, occupational and social status, degree of social independence, and severity of circulatory disorders. The surgical treatment and rehabilitation policy for patients with unilateral PAD of the lower extremities was defined taking into account the social factory.

Adult↗
PubMed2003

[Treatment and rehabilitation strategy for patients with lower extremity stump ischemia].

The paper is concerned with evidence for the choice of the treatment and rehabilitation policy of patients suffering from lower extremity stump ischemia. Altogether 446 patients with obliterating diseases of arteries and unilateral post-amputation defects of the lower extremities were examined. Of these, degree III-IV stump ischemia was verified in 90 patients, transient stump ischemia was present in 259 patients. In 30 patients, stump pains or defects of the skin were determined by defects and discuses of the stump; 67 patients were identified to have no clinical signs of ischemia and no defects or diseases of the stump, 43 patients underwent arterial reconstructions whereas reamputations of the extremity were undertaken in 29 patients. The remaining patients with stump ischemia received conservative therapy. The algorithm of the choice of the treatment policy and rehabilitation of patients was worked out depending on the severity of the clinical manifestations of stump ischemia and the level of post-amputation defect.

Adult↗
PubMed2000

The function of endogenous protective systems in patients with insulin-dependent diabetes mellitus and polyneuropathy: effect of antioxidant therapy.

alpha-Lipoic acid is a very efficient antioxidants for the treatment and prevention of diabetic neuropathy. The aim of the present study was to evaluate the function of nitric oxide (NO) and stress proteins (HSP72) in insulin-dependent diabetes complicated by polyneuropathy and possible contribution of these systems to the therapeutic effects of alpha-lipoic acid. Plasma content of nitrites and nitrates in diabetic patients was almost 2-fold below the normal. The treatment with alpha-lipoic acid completely normalized the plasma content of these stable NO metabolites. The majority of patients had also low level of HSP72. Positive clinical effects of alpha-lipoic acid were accompanied by normalization of HSP72 synthesis. Thus, activation of the NO and HSP protective systems is involved in the therapeutic effect of alpha-lipoic acid in diabetic patients (type 1 diabetes mellitus) with polyneuropathy.

Adolescent↗
PubMed1998

[Choice of level and establishment of limb stump in patients with obliterative arteries diseases].

335 patients with obliterative diseases of arteries of the low extremities were examined. Results of motor rehabilitation depend on the severity of post-amputation defect of the extremity and functional condition of the stump. The lower is the level of the amputation the higher is the effectiveness of the rehabilitational measures. Ischemia of femoral stump springs up rarely but its course is mare severe than ischemia of the stump of the shin, which is confirmed by the data of clinical examination, investigation of biochemical parameters of the blood and mortality rate. For prophylaxis of ischemia of the stump it is suggested simultaneously with the amputation of the extremity to perform reconstructive procedures on the arteries, aimed at restoration of blood flow through the profound femoral artery. This policy provides the possibility to form a long functional stump of the extremity and to improve results of motor rehabilitation.

Adult↗
PubMed1996

[Surgical treatment of ischemia of the stump of the lower extremity].

The authors observed 22 patients who had obliteration of leg arteries and stage III-IV leg stump ischemia. The reconstruction of the stump circulation by using a deep artery of the thigh allowed to stop the ischemia and make the stump more functional or gave an opportunity to make Gritty operation.

Adult↗
PubMed1992

[The significance of the mu- and delta-opiate receptors in realizing enkephalin action on the course of hypoxic hypoxia].

New enkephalins analogues have been synthesized. They are characterized by linear, cyclic and branched peptide chain. A relationship has been established between antihypoxic activity of opioid peptides an their interaction with opiate receptors. Compounds efficiently interacting with mu-receptors irrespective of delta-receptors affinity, promote longer survival of mice in hypoxia. The antihypoxic effect of opioids is proportional to their specificity to mu-receptors.

Animals↗
PubMed1992

[Functional state of the endogenous opioid peptide system in traumatic shock in rats].

The experiments have been performed on 120 Wistar rats and 546 CBWH mice. Met-enkephalin (ME) and beta-endorphin (BE) levels were determined to increase in blood and mid-brain 3 hours later after soft tissue compression of pelvic extremities. 48 hours later after six-hour compression BE and ME level in blood was increased, BE concentration in blood was also increased, and enkephalins' content in brain and blood was decreased as against the control. Opioid peptides influence on the host compression period has been studied. D-agonists were established to decrease, but mu-agonists were established to increase mice survival in shock. Opioid peptides' significance in traumatic shock pathogenesis is being discussed.

Animals↗
PubMed1990

[The met-enkephalin and beta-endorphin content of the blood in the early period after acute blood loss in rats].

The experiments have been performed on 164 rats and 110 mice. Met-enkephalin and beta-endorphin concentration was established to increase in the blood in the early period after acute blood loss in rats who survived after 24 hours of a follow up in the group of animals, who died during 24 hours follow up, the momentary beta-endorphin increase was noted at the 1st minute of the experiment; met-enkephalin contents in blood wasn't essentially changed. mu-Receptors' agonist DAGO injection significantly decreased rat mortality in a posthemorrhagic period. The correlation between arterial pressure values and beta-endorphin and met-enkephalin contents in the blood wasn't defined. The opioid peptides' ability to increase the organism stability to hypoxia was determined. Beta-endorphin and met-enkephalin significance in the pathogenesis of a posthemorrhagic period in acute blood loss is being discussed.

Acute Disease↗
PubMed1990

[Pathophysiological and clinical evaluation of the effectiveness of dalargin in the treatment of arterial occlusive diseases of the lower extremities].

Eighty seven patients with Stages II-III vascular occlusions in the lower extremities were examined. The clinical and biochemical parameters of the course of the disease were found to improve in the patients who received in earlier periods dalargin supplemented to the combined therapy than in those from a matched group. There was a decrease in femoral venous blood lactate concentrations in the diseased extremity, blood cholesterol and parathyroid hormone levels. The mechanisms responsible for effects of dalargin on metabolic parameters and clinical indices of the patients' condition were also discussed. Whether it is possible to use dalargin in the combined therapy for extremity vascular occlusive diseases is considered.

Adult↗
PubMed1990

[Regional blood lactate level in arterial occlusive diseases].

Fifty-seven patients with obliterating diseases of the lower limb arteries were examined. The concentration of lactate in the venous blood and the venous-arterial difference in the blood lactate level in the affected limb were found to be increased. A relationship between the marked character of these shifts and the severity of the ischemic syndrome was noted. The authors discuss the possibility of using the values of the lactate content in the regional blood as criteria for evaluating the efficacy of treatment and the prognosis of obliterating diseases of the lower limb arteries.

Adult↗
PubMed1990

[Effect of enkephalins and naloxone on the activity of the kallikrein-kinin system in experimental hemorrhagic shock].

The effect of enkephalin derivates with different receptor subtype specificity and opioid antagonist naloxone on kallikrein-kinin system was studied in anaesthetized rats exposed to 30% hemorrhage. Hemorrhage by itself caused only a slight activation of KKS. Pretreatment with naloxone induced a significant activation of KKS, which was potentiated by subsequent hemorrhage.

Animals↗